Accutane (Isotretinoin) - Skin Care
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Accutane (Isotretinoin)

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Accutane (Isotretinoin)

Class and Category of Drug

Before you buy Accutane (Isotretinoin) online, read common information about the medication.

Chemical class: Retinoid

Therapeutic class: Acne inhibitor

Pregnancy category: X

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Drug Indications and Dosages

Before purchase Accutane (Isotretinoin) online , you must read how it works.

To treat severe recalcitrant nodular acne unresponsive to conventional therapy

Capsules

Adults. Initial: 0.5 mg to 1 mg/kg daily in 2 divided doses, increased as needed up to 2 mg/kg daily given in 2 divided doses. Maximum: 2 mg/kg daily. Course of therapy given for 15 to 20 wk with second course given, as needed, after a period of 2 mo or more off therapy.

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Contraindications of Drug

Hypersensitivity to isotretinoin or any of its components, hypersensitivity to parabens, pregnancy

Generic Drug Interactions

Drugs

corticosteroids (systemic): Possibly increased risk of osteoporosis

hormonal contraceptives including microdosed progesterone preparations, medroxyprogesterone injection, levonorgestrel implants: Possibly decreased effectiveness of contraceptive

phenytoin: Possibly increased risk of osteomalacia

tetracydines: Increased risk of benign intracranial hypertension vitamin A supplements: Increased risk of additive toxic effects

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Drugs Adverse Reactions

Central Nervous System: Aggressive or violent behavior, depression, dizziness, drowsiness, emotional instability, fatigue, headache, insomnia, lethargy, malaise, nervousness, paresthesias, pseudotumor cerebri, psychosis, seizures, stroke, suicidal ideation, syncope, weakness

Cardiovascular: Chest pain, decreased high-density lipoprotein level, edema, elevated creatinine phosphokinase level, hypercholesteremia, hypertriglyceridemia, palpitation, stroke, tachycardia, vascular thrombotic disease, vasculitis

Endocrine: Abnormal menses, alterations in blood glucose levels

Eyes, Ears, Nose, And Throat: Bleeding and inflammation of gums, cataracts, color vision disorder, conjunctivitis, corneal opacities, decreased night vision, dry mouth or nose, dry eyes, epistaxis, eyelid inflammation, hearing impairment, keratitis, optic neuritis, photophobia, tinnitus, visual disturbances, voice alteration

Gastrointestinal: Colitis, hepatitis, ileitis, inflammatory bowel disease, liver enzyme elevation, nausea, pancreatitis

Genitourinary: Glomerulonephritis, hematuria, proteinuria, WBCs in urine

Hematologic: Anemia, agranulocytosis, neutropenia, platelet count elevation, sedimentation rate elevation, thrombocytopenia

Musculoskeletal: Arthralgia, arthritis, back pain (children), bone abnormalities, calcification of tendons and ligaments, premature epiphyseal closure, tendonitis

Respiratory: Bronchospasms, respiratory infection

Skin: Alopecia, bruising, disseminated herpes simplex, dry lips or skin, eczema, eruptive xanthomas, facial erythema, flushing, fulminant acne, hair abnormalities, hirsutism, hyperpigmentation, hypopigmentation, increased sunburn susceptibility, infections, nail dystrophy, paronychia, peeling of palms and soles, photoallergic or photosensitizing reactions, pruritus, pyogenic granuloma, rash, seborrhea, skin fragility, sweating, urticaria

Other: Abnormal wound healing, alkaline phosphatase increase, allergic reactions, hyperuricemia, lymphadenopathy, weight loss

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Nursing Considerations for Generic Drugs

• Ensure that women of childbearing age have had two negative urine or serum pregnancy tests with a sensitivity of at least 50 mlU/ml, joined the Accutane Survey, signed the consent form, and watched the videotape provided by manufacturer prior to beginning isotretinoin therapy.

WARNING Notify prescriber if elevated serum triglyceride levels can't be controlled or if symptoms of pancreatitis occur (abdominal pain, nausea, vomiting). Drug may need to be discontinued because fatal hemorrhagic pancreatitis has occurred with drug use.

• Obtain serum lipid level before therapy and periodically thereafter, as ordered, to detect elevated lipid levels that result from isotretinoin therapy.

• Monitor liver enzyme levels periodically, as ordered, because drug can cause hepatitis.

• Assess patient frequently for adverse reactions and report to prescriber any that occur; drug may have serious adverse effects that require discontinuation.

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Isotretinoin

Preparations

International Brand Drug Names

The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.


British Pharmacopoeia, 2008 edition: Isotretinoin Capsules; Isotretinoin Gel;
The United States Pharmacopeia 31, 2008: Isotretinoin Capsules.

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