Aldactone (Spironolactone) - Blood Pressure/Cholesterol
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Top » Catalog » Blood Pressure/Cholesterol » Aldactone (Spironolactone)


Aldactone (Spironolactone)

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Aldactone (Spironolactone)

Class and Category of Drug

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Chemical class: Aldosterone antagonist

Therapeutic class: Aldosterone antagonist, antihypertensive, diagnostic aid for primary hyperaldosteronism, diuretic

Pregnancy category: Not rated

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Drug Indications and Dosages

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To treat edema cause by heart failure, hepatic cirrhosis, or nephrotic syndrome

Tablets

Adults. Initial: 25 to 200 mg daily in divided doses b.i.d. to q.i.d. for at least 5 days. Maintenance: 75 to 400 mg daily in divided doses b.i.d. to q.i.d. Maximum: 400 mg daily.

Children. Initial: 1 to 3 mg/kg daily as a single dose or in divided doses b.i.d. to q.i.d. for at least 2 wk; adjusted, as needed, after 5 days. Maximum: 3 times initial dose.

To treat hypertension

Tablets

Adults. Initial: 50 to 100 mg daily as a single dose or in divided doses b.i.d. to q.i.d. for at least 2 wk; gradually adjusted every 2 wk, as needed, to control blood pressure, up to 200 mg daily. Maximum: 400 mg daily.

Children. Initial: 1 to 3 mg/kg daily as a single dose or in divided doses b.i.d. to q.i.d. for at least 2 wk; adjusted, as needed, after 5 days. Maximum: 3 times initial dose.

To aid in the diagnosis of primary hyperaldosteronism

Tablets

Adults. For long test, 400 mg daily in divided doses b.i.d. to q.i.d. for 3 to 4 wk; for short test, 400 mg daily in divided doses b.i.d. to q.i.d. for 4 days.

To treat primary hyperaldosteronism

Tablets

Adults. 100 to 400 mg daily in divided doses b.i.d. to q.i.d. before surgery. Maximum: 400 mg daily.

Dosage Adjustment Long-term maintenance dosage decreased for patients at risk for complications during surgery.

To substitute as therapy for diuretic-induced hypokalemia

Tablets

Adults. 25 to 100 mg daily as a single dose or in divided doses b.i.d. to q.i.d. Maximum: 400 mg daily.

Contraindications of Drug

Read contraindications if you want cheap Aldactone (Spironolactone) online.

Acute renal insufficiency, anuria, hyperkalemia, hypersensitivity to spironolactone or its components

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Generic Drug Interactions

Drugs

ACE inhibitors, cyclosporine, other potassium-sparing diuretics, potassium-containing drugs, potassium supplements: Increased risk of hyperkalemia

digoxin: Possibly increased half-life of digoxin

exchange resins (sodium cycle), such as sodium polystyrene sulfonate: Increased risk of hypokalemia and fluid retention heparin, oral anticoagulants: Decreased anticoagulant effect of these drugs hypotension-producing drugs: Possibly potentiated antihypertensive or diuretic effect of spironolactone lithium: Possibly lithium toxicity nonsteroidal anti-inflammatory drugs (NSAIDs), sympathomimetics: Decreased anti-hypertensive effect of spironolactone

Foods

low-salt milk, salt substitutes: Increased risk of hyperkalemia

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Drugs Adverse Reactions

Central Nervous System: Dizziness, encephalopathy, fatigue, headache

Eyes, Ears, Nose, And Throat: Increased intraocular pressure, nasal congestion, tinnitus, vision changes

Endocrine: Gynecomastia

Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, flatulence, nausea, vomiting

Genitourinary: Impotence

Hematologic: Aplastic anemia, neutropenia

Respiratory: Cough, dyspnea

Musculoskeletal: Arthralgia, back and leg pain, muscle weakness, myalgia

Other: Hyperkalemia

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Spironolactone

Preparations

International Brand Drug Names

The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.


British Pharmacopoeia, 2008 edition: Spironolactone Tablets;
The United States Pharmacopeia 31, 2008: Spironolactone and Hydrochlorothiazide Tablets; Spironolactone Tablets.

Proprietary Preparations


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