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Alesse (Levonorgestrel)

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Alesse (Levonorgestrel)

Class and Category of Drug

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Chemical class: Progesterone derivative, steroid hormone

Therapeutic class: Antianorectic, anti-cachectic, antineoplastic, ovarian hormone replacement

Pregnancy category: D (hydroxyprogesterone, megestrol [tablets], progesterone); X (levonorgestrel, medroxyprogesterone [parenteral], megestrol [parenteral and suspension], norethindrone, norgestrel); NR (medrogestone, medroxyprogesterone [tablets])

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Drug Indications and Dosages

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To treat renal cancer

Intramuscular Injection (Medroxyprogesterone)

Adults and adolescents. Initial: 400 mg to 1 g every wk until improvement and stabilization. Maintenance: 400 mg or more every mo.

To treat breast cancer

Tablets (Megestrol)

Adults and adolescents. 160 mg daily as single dose or in divided doses.

To treat endometrial cancer

Tablets (Megestrol)

Adult and adolescent women. 40 to 320 mg daily in divided doses.

Intramuscular Injection (Medroxyprogesterone)

Adults and adolescents. Initial: 400 mg to 1 g every wk until improvement and stabilization. Maintenance: 400 mg or more every mo.

To treat anorexia, cachexia, or significant weight loss in patients who have AIDS

Suspension (Megestrol)

Adults and adolescents. 800 mg daily for the first mo, and then 400 or 800 mg daily for the next 3 mo.

To treat endometriosis

Tablets (Norethindrone Acetate)

Adult and adolescent women. Initial: 5 mg daily for 2 wk, increased by 2.5 mg daily at 2-wk intervals to total dose of 15 mg daily. Maintenance: 15 mg daily for 6 to 9 mo unless temporarily discontinued because of breakthrough menstrual bleeding.

As adjunct to treat endometrial shedding in menopausal women

Tablets (Medrogestone) Adult and adolescent women. 5 to 10 mg daily on days 15 through 25 of menstrual cycle.

To treat secondary amenorrhea

Tablets (Medrogestone) Adult and adolescent women. 5 to 10 mg daily on days 15 through 25 of menstrual cycle.

Tablets (Medroxyprogesterone) Adult and adolescent women. 5 to 10 mg daily for 5 to 10 days, starting anytime during menstrual cycle.

Tablets (Norethindrone Acetate) Adult and adolescent women. 2.5 to 10 mg daily on days 5 through 25 of menstrual cycle. Or, 2.5 to 10 mg daily for 5 to 10 days during last half of menstrual cycle. Capsules (Progesterone) Adult and adolescent women. 400 mg daily in evening for 10 days.

Intramuscular Injection (Hydroxyprogesterone)

Adult and adolescent women. 375 mg as one-time dose.

Intramuscular Injection (Progesterone)

Adult and adolescent women. 5 to 10 mg daily for 6 to 10 days. Or, 100 to 150 mg injected as single dose. Vaginal Gel (Progesterone) Adult and adolescent women. 45 mg (1 applicatorful of 4% Vaginal gel) every other day for up to 6 doses. Dosage increased, as needed, to 90 mg (1 applicatorful of 8% Vaginal gel) every other day for up to 6 doses.

To treat dysfunctional uterine bleeding

Tablets (Medrogestone) Adult and adolescent women. 5 to 10 mg daily on days 15 through 25 of menstrual cycle.

Tablets (Medroxyprogesterone) Adult and adolescent women. 5 to 10 mg daily for 5 to 10 days, starting on day 16 or 21 of menstrual cycle.

Tablets (Norethindrone Acetate) Adult and adolescent women. 2.5 to 10 mg daily on days 5 through 25 of menstrual cycle. Or, 2.5 to 10 mg daily for 5 to 10 days during last half of menstrual cycle.

Intramuscular Injection (Hydroxyprogesterone)

Adult and adolescent women. 375 mg as one-time dose.

Intramuscular Injection (Progesterone)

Adult and adolescent women. 5 to 10 mg daily for 6 consecutive days.

To induce menses

Tablets (Medrogestone) Adult and adolescent women. 5 to 10 mg daily on days 15 through 25 of the menstrual cycle.

Tablets (Medroxyprogesterone) Adult and adolescent women. 10 mg daily for 10 days, starting on day 16 of menstrual cycle. Repeated for 2 or more cycles if bleeding is satisfactorily controlled.

Intramuscular Injection (Hydroxyprogesterone)

Adult and adolescent women. 125 to 250 mg on day 10 of menstrual cycle, repeated every 7 days until suppression is no longer desired.

To prevent pregnancy (postcoital)

Tablets (Levonorgestrel) Adult and adolescent women. 0.75 mg as soon as possible within 72 hr of intercourse. Second dose given 12 hr later.

To prevent pregnancy

Tablets (Norethindrone) Adult and adolescent women. 0.35 mg daily, starting on day 1 of menstrual cycle and continuing uninterrupted through the year, whether or not menstrual bleeding occurs.

Tablets (Norgestrel) Adult and adolescent women. 0.075 mg daily starting on day 1 of menstrual cycle and continuing uninterrupted throughout the year, whether or not menstrual bleeding occurs.

I.M. Injection (Medroxyprogesterone)

Adult and adolescent women. 150 mg every 3 mo.

Subdermal Implant (Levonorgestrel) Adult and adolescent women. One set of implants surgically inserted every 2 yr.

All our medications come with complete instructions, detailed description, interaction, indication, and any other information that the clients need in order to use the pills in a responsible manner.

Contraindications of Drug

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Active thromboembolic disorder; thrombophlebitis; significant hepatic disease; hyper-sensitivity to peanuts (progesterone), progestins, or their components; known or suspected breast cancer; pregnancy; undiagnosed genital, uterine, or urinary tract bleeding

Generic Drug Interactions

Drugs

aminoglutethimide: Possibly decreased blood level of medroxyprogesterone carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin: Possibly decreased effectiveness of progestin thyroid hormone: Decreased thyroid hormone effectiveness

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Drugs Adverse Reactions

Central Nervous System: Altered or reduced coordination or speech, depression, dizziness, drowsiness, fatigue, headache, irritability, migraine, mood changes, nervousness, post-menopausal dementia, syncope, unusual tiredness or weakness

Cardiovascular: Fluid retention; hypotension; numbness or pain in chest, arm, or leg; thromboembolism

Endocrine: Adrenal insufficiency or suppression, breast pain or tenderness, Cushing's syndrome, decreased T3 resin uptake, delayed return of fertility in women, elevated thyroid-binding globulin, galactorrhea, hyperglycemia, Vaginal spotting

Eyes, Ears, Nose, And Throat: Gingival bleeding, swelling, or tenderness; vision changes or loss

Gastrointestinal: Abdominal cramps or pain, diarrhea, nausea, vomiting

Genitourinary: Amenorrhea, breakthrough bleeding or metromenorrhagia, decreased libido, hyper-menorrhea, ovarian enlargement or cysts

Hematologic: Clotting and bleeding abnormalities

Musculoskeletal: Back pain, decreased bone density, osteoporosis, osteoporotic fractures

Respiratory: Dyspnea

Skin: Acne, alopecia, melasma, rash

Other: Anaphylaxis; facial fullness; hot flashes; injection or implantation site irritation, pain, or redness; weight gain

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Levonorgestrel

Preparations

International Brand Drug Names

The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.


British Pharmacopoeia, 2008 edition: Levonorgestrel and Ethinylestradiol Tablets; Levonorgestrel Tablets; Norgestrel Tablets;
The United States Pharmacopeia 31, 2008: Levonorgestrel and Ethinyl Estradiol Tablets; Norgestrel and Ethinyl Estradiol Tablets; Norgestrel Tablets.

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