Arava (Leflunomide)
Class and Category of Drug
Before you buy Arava (Leflunomide) online, read common information about the medication.
Chemical class: Malonitrilamide immunomodulator
Therapeutic class: Antirheuinatic
Pregnancy category: X
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Drug Indications and Dosages
Before purchase Arava (Leflunomide) online , you must read how it works.
To relieve symptoms of active rheumatoid arthritis, improve physical function and slow disease progression
Tablets
Adults. Loading: 100 mg daily for 3 days. Maintenance: 20 mg daily, reduced to 10 mg daily if poorly tolerated. Maximum: 20 mg/ day.
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Contraindications of Drug
Read contraindications if you want cheap Arava (Leflunomide) online.
Hypersensitivity to leflunomide or its components, pregnancy
Generic Drug Interactions
Drugs
activated charcoal, cholestyramine: Decreased blood leflunomide level live-virus vaccines:Possibly adverse reactions to vaccines caused by leflunomide-induced immunosuppression
methotrexate: Risk of hepatotoxicity
NSAIDs: Possibly impaired NSAID' metabolism
rifampin, tolbutamide: Increased blood leflunomide level
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Drugs Adverse Reactions
Central Nervous System: Anxiety, dizziness, drowsiness, fatigue, fever, headache, paresthesia
Cardiovascular: Chest pain, hypertension, palpitations, tachycardia
Eyes, Ears, Nose, And Throat: Blurred vision, conjunctivitis, dry mouth, epistaxis, mouth ulcers, pharyngitis, rhinitis, sinusitis
Gastrointestinal: Abdominal pain, cholestasis, constipation, diarrhea, elevated liver function test results, flatulence, gastritis, gastroenteritis, hepatic failure, hepatitis, nausea, vomiting
Genitourinary: Urinary tract infection
Hematologic: Agranulocytosis, anemia, pancytopenia, thrombocytopenia
Musculoskeletal: Back pain, synovitis, tendinitis
Respiratory: Asthma, bronchitis, dyspnea, interstitial lung disease, respiratory tract infection
Skin: Alopecia (transient), erythematous rash, jaundice, pruritus, urticaria
Other: Sepsis, weight loss
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Nursing Considerations for Generic Drugs
• Leflunomide isn't recommended for patients with severe immunodeficiency, bone marrow dysplasia, or severe, uncontrolled infections because of its immuno-suppressant effect.
• Test patient for latent tuberculosis before starting leflunomide. If positive, expect standard medical treatment to be given before leflunomide therapy starts.
• Obtain baseline blood pressure before starting leflunomide, and monitor periodically thereafter because drug may cause hypertension.
• Assess liver enzyme (alanine aminotransferase and aspartate aminotransferase) levels at start of therapy, monthly during first 6 months, and if stable, every 6 to 8 weeks thereafter, as ordered. Expect to stop drug if hepatic dysfunction develops.
• Obtain platelet count, WBC count, and hemoglobin or hematocrit at start of therapy and every 4 to 8 weeks thereafter, as ordered.
• Notify prescriber if patient develops serious infection because drug may need to be interrupted and cholestyramine or charcoal given to eliminate drug rapidly.
WARNING Monitor patient's respiratory function closely because drug may cause interstitial lung disease that could become life-threatening. If patient develops a cough and dyspnea, notify prescriber; drug may need to be stopped, and patient may need cholestyramine or charcoal to eliminate drug rapidly.
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Leflunomide
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
The United States Pharmacopeia 31, 2008: Leflunomide Tablets.
Proprietary Preparations
Argentina: Afiancen; Arava; Filartros; Inmunoartro; Lefluar; Molagar;
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The pharmaceutical companies our pharmacies buy from follow strict WHO standards for GMP.
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