Baclofen (Lioresal)
Class and Category of Drug
Before you buy Baclofen (Lioresal) online, read common information about the medication.
Chemical class: Gamma-aminobutyric acid (GABA) chlorophenyl derivative
Therapeutic class: Skeletal muscle relaxant, spasmolytic
Pregnancy category: C
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Drug Indications and Dosages
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To relieve symptoms of spasticity caused by multiple sclerosis (particularly flexor spasms and pain, clonus, and muscle rigidity) and spasticity from spinal cord injury or disease and brain injury
Tablets
Adults and children age 12 and over. 5 mg t.i.d. for 3 days; then 10 mg t.i.d. for 3 days;then 15 mg t.i.d. for 3 days; then 20 mg t.i.d. for 3 days; then increased if needed up to 80 mg daily. Usual: dosage ranges from 40 to 80 mg daily.
To relieve severe symptoms of spasticity of spinal cord origin when symptoms don't respond to oral drug or when oral drug causes severe adverse CNS effects
Intrathecal Bolus, Intrathecal Infusion
Adults.
For screening before implantable pump insertion: 50 meg in 1 ml sterile preservative-free sodium chloride for injection as bolus injection into intrathecal space over 1 min or more. After 4 to 8 hr, if symptoms don't improve as much as desired, second bolus of 75 meg in 1.5 ml of sterile preservative-free sodium chloride for injection, injected after 24 hr, followed by third bolus of 100-mcg/2 ml dilution injected after another 24 hr, if needed.
After implantable pump insertion: Effective screening dose doubled and infused over 24 hr. Or effective screening dose (if it provided desired effects for more than 12 hr) infused over 24 hr.
For spasticity of spinal cord origin after implantable pump insertion: After first 24 hr, daily dose increased by 10% to 30% once every 24 hr until desired effects achieved.
For spasticity of cerebral origin after implantable pump insertion: Daily dose increased by 5% to 15% once every 24 hr until desired effects achieved.
For long-term maintenance therapy in spasticity of spinal cord origin: 12 to 2,003 meg/ day (usual dose 300 to 800 meg daily). Lowest possible therapeutic dose should be used. If adverse effects occur, daily dose may be decreased by 10% to 20%. During periodic pump refills, daily dose may be increased by 10% up to 40% to control symptoms adequately.
For long-term maintenance therapy in spasticity of cerebral origin: 90 to 703 meg daily (usual) but ranging from 22 to 1,400 meg/ day. If adverse effects occur, daily dose may be decreased by 10% to 20%. During periodic pump refills, daily dose may be increased by 5% to 20% to control symptoms adequately.
Children.
For screening before implantable pump insertion: 1 ml of 50-mcg/ml dilution or 1 ml of 25-mcg/ml dilution (if child is very young) as bolus injection into intrathecal space over 1 min or more. After 4 to 8 hr, if symptoms don't improve as desired, second bolus of 75 meg in 1.5 ml of sterile preservative-free sodium chloride for injection, injected after 24 hr, followed by third bolus of 100-mcg/2 ml dilution, injected after another 24 hr, if needed.
After implantable pump insertion: Daily dose increased by 5% to 15% once every 24 hr until desired effect is achieved. For maintenance therapy: In children over age 12 90 to 703 meg daily (usual), ranging from 22 to 1,400 meg daily. In children under age 12 274 meg daily (average), ranging from 24 to 1,199 meg daily.
Dosage Adjustment Dosage reduced for patients with renal impairment because drug is excreted primarily unchanged by kidneys.
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Contraindications of Drug
Read contraindications if you want cheap Baclofen (Lioresal) online.
Hypersensitivity to baclofen; treatment of skeletal muscle spasm resulting from rheumatic disorders, cerebral palsy, Parkinson's disease, or stroke (oral form only)
Generic Drug Interactions
Drugs
CNS depressants: Possibly increased CNS depression
Epidural morphine: Possibly hypotension and dyspnea
Activities
alcohol use: Possibly increased CNS depression
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Drugs Adverse Reactions
Central Nervous System: Abnormal gait, anxiety, ataxia, chills, coma, confusion, depression, dizziness, drowsiness, dystonia, emotional lability, euphoria, excitement, fatigue, fever, hallucinations, headache, hypertonia, hypothermia, hypotonia, impaired concentration, insomnia, lack of coordination, lethargy, memory loss, paresthesia, personality disorder, seizures, somnolence, stroke, syncope, tremor, weakness
Cardiovascular: Bradycardia, chest pain, chest tightness, deep vein thrombosis, hypertension, orthostatic hypotension, palpitations, peripheral edema
Eyes, Ears, Nose, And Throat: Amblyopia, blurred vision, diplopia, dry mouth, miosis, mydriasis, nasal congestion, nystagmus, photophobia, ptosis, rhinitis, slurred speech, strabismus, taste loss, tinnitus
Endocrine: Hyperglycemia
Gastrointestinal: Abdominal pain, anorexia, constipation, dysphagia, elevated liver function test results, flatulence, ileus, indigestion, nausea, vomiting
Genitourinary: Albuminuria, bladder spasms, dysuria, enuresis, hematuria, impotence, renal failure, sexual dysfunction, urinary frequency, urinary incontinence, urine retention
Hematologic: Anemia
Musculoskeletal: Muscle twitching
Respiratory: Aspiration pneumonia, pulmonary embolism, respiratory depression
Skin: Alopecia, diaphoresis, facial edema, flushing, pruritus, rash, urticaria, wound dehiscence
Other: Dehydration, infection at pump implantation site, weight loss
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Nursing Considerations for Generic Drugs
Expect to start baclofen therapy at a low dose and gradually increase until desired effects are achieved.
WARNING Before screening dose is given, expect prescriber to make sure patient is free of infection to prevent systemic infection from interfering with patient's response. Before implantable pump insertion, also expect prescriber to make sure patient is free of infection to reduce risk of complications and interference with determining most appropriate dose.
Use baclofen cautiously in patients with a history of autonomic dysreflexia. Nociceptor stimulation may precipitate autonomic dysreflexia. Be aware that abrupt withdrawal of intrathecal infusion may produce symptoms similar to autonomic dysreflexia, high fever, life-threatening complications such as multiple organ-system failure, and death.
WARNING Never give intrathecal form of baclofen by I.V., I.M., or subcutaneous routes.
Assess for signs of effectiveness, such as relief of spasms, pain, and muscle rigidity.
Because CNS depression can occur, take precautions to prevent injury. Also take precautions for patients who use spasticity to maintain locomotion or upright posture and balance. Relief of spasticity may increase risk of falls and injury.
WARNING Because continuous intrathecal infusion increases risk of life-threatening CNS depression, keep emergency equipment nearby.
Expect baclofen to be discontinued slowly; hallucinations and seizures may occur with abrupt withdrawal.
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