Benemid (Probenecid)
Class and Category of Drug
Before you buy Benemid (Probenecid) online, read common information about the medication.
Chemical class: Sulfonamide derivative
Therapeutic class: Antibiotic adjunct, antigout, uricosuric
Pregnancy category: Not rated
Drug Indications and Dosages
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To treat chronic gouty arthritis and hyperuricemia due to chronic gout
Tablets
Adults and adolescents. Initial: 250 mg b.i.d. for 1 wk; then increased to maintenance dosage. Maintenance: 500 mg b.i.d.; if not effective or 24-hr uric acid excretion isn't greater than 700 mg, dosage increased by 500 mg/day every 4 wk, as needed and prescribed, up to a maximum of 3 g daily. If no acute attacks of gout occur over next 6 mo and serum uric acid level is within normal limits, dosage decreased, as prescribed, by 500 mg every 6 mo until lowest effective maintenance dose is reached. Maximum: 3 g daily.
Dosage Adjustment Dosage possibly increased for patients with mild renal dysfunction, except for elderly patients, who require a dosage reduction.
As adjunct to antibiotic therapy with penicillins and some cephalosporins
Tablets
Adults, adolescents age 14 and over, and children weighing more than 50 kg (110 lb). 500 mg q.i.d.; if given with intravenous or intramuscular antibiotic, administer at least 30 min before antibiotic.
Children ages 2 to 14 weighing up to 50 kg. 25 mg/kg as single dose, then 10 mg/kg q.i.d.; if given with intravenous or intramuscular antibiotic, give at least 30 min before antibiotic.
As adjunct to treat sexually transmitted diseases
Tablets
Adults and adolescents. 1 g as single dose, given with appropriate antibiotic.
As adjunct to treat pediatric gonorrhea
Tablets
Postpubertal children and children weighing more than 45 kg (99 lb). 1 g as single dose, given with appropriate antibiotic.
As adjunct to treat neurosyphilis
Tablets
Adults and adolescents. 500 mg q.i.d. with 1 daily dose (2.4 million units) of penicillin G procaine for 10 to 14 days.
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Contraindications of Drug
Read contraindications if you want cheap Benemid (Probenecid) online.
Age less than 2 years, blood dyscrasias, hypersensitivity to probenecid or its components, renal calculi (urate)
Generic Drug Interactions
Drugs
acyclovir: Decreased renal tubular secretion of acyclovir
allopurinol: Additive antihyperuricemic effects
aminosalicylate sodium, cephalosporins, ciprofloxacin, clofibrate, dapsone, ganciclovir, imipenem, methotrexate, nitrofurantoin, norfloxacin, penicillins: Increased and possibly prolonged blood levels of these drugs, increased risk of toxicity antineoplastics (rapidly cytolytic): Possibly uric acid nephropathy diazoxide, mecamylamine, pyrazinamide: Increased risk of hyperuricemia, decreased probenecid effectiveness dyphylline: Increased half-life of dyphylline furosemide: Increased blood furosemide level
heparin: Increased and prolonged anticoagulant effect
indomethacin, ketoprofen, other NSAIDs: Possibly increased adverse effects lorazepam, oxazepam, temazepam: Increased effects of these drugs, possibly excessive sedation
* For renal clearance of uric acid; 2 hr for effect on blood antibiotic level. f For effect on blood antibiotic level;unknown for renal clearance of uric acid.
riboflavin: Decreased gastrointestinal absorption of ribo-flavin
rifampin, sulfonamides: Increased blood levels of these drugs and, possibly, toxicity salicyhtes: Decreased uricosuric effects of probenecid
sodium benzoate and sodium phenylacetate: Decreased renal elimination of these drugs sulfonylureas: Increased sulfonylurea half-life
thiopental: Prolonged thiopental effect zidovudine: Increased risk of zidovudine toxicity
Activities
alcohol use: Increased risk of hyperuricemia, decreased probenecid effectiveness
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Drugs Adverse Reactions
Central Nervous System: Dizziness, headache
Eyes, Ears, Nose, And Throat: Sore gums
Gastrointestinal: Anorexia, nausea, vomiting
Genitourinary: Hematuria, renal calculi (urate), renal colic, urinary frequency
Musculoskeletal: Costovertebral pain; joint pain, redness, and swelling
Skin: Facial flushing, pruritus, rash, urticaria
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Nursing Considerations for Generic Drugs
Be aware that probenecid therapy shouldn't start until acute gout attack has subsided. If acute attack starts during therapy, continue therapy as prescribed.
Use drug cautiously in patients with peptic ulcer of days!
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Expect to give sodium bicarbonate (3 to 7.5 g daily) or potassium citrate (7.5 g daily), as prescribed, to keep urine alkaline and prevent renal calculus formation.
Monitor CBC, serum uric acid level, and liver and renal function test results during therapy.
Closely monitor patients receiving intermittent therapy because they're more likely to develop allergic reactions.
Check blood glucose level often in diabetic patient who takes a sulfonylurea because of the risk of drug interactions.
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Probenecid
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Probenecid Tablets;
The United States Pharmacopeia 31, 2008: Ampicillin and Probenecid for Oral Suspension; Probenecid and Colchicine Tablets; Probenecid Tablets.
Proprietary Preparations
Australia: Pro-Cid;
Canada: Benuryl;
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Multi-ingredient
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US or USA: ColBenemid. Used as an adjunct in:
Brazil: Emicilin; Gonol;
Spain: Blenox.
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