Betapace (Sotalol)
Class and Category of Drug
Before you buy Betapace (Sotalol) online, read common information about the medication.
Chemical class: Methanesulfonanilide
Therapeutic class: Class III antiarrhythmic
Pregnancy category: B
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Drug Indications and Dosages
Before purchase Betapace (Sotalol) online , you must read how it works.
To treat life-threatening ventricular arrhythmias
Tablets
Adults. Initial: 80 mg b.i.d. Maintenance: 160 to 320 mg daily in divided doses b.i.d. or t.i.d. Maximum: 640 mg daily.
Dosage Adjustment If creatinine clearance is 30 to 60 ml/min/1.73 m2, dosage interval extended to every 24 hr; if creatinine clearance is less than 30 ml/min/1.73 m2, dosage interval extended to every 36 to 48 hr, according to response; if creatinine clearance less than 10 ml/min/1.73 m2, dosage adjusted as prescribed.
To maintain normal sinus rhythm in patients with highly symptomatic atrial fibrillation who are currently in sinus rhythm
Tablets
Adults. Initial: If creatinine clearance is 40 to 60 ml/min/1.73 m2, give 80 mg daily; if creatinine clearance exceeds 60 ml/min/ 1.73 m2, give 80 mg b.i.d. Maintenance: After at least 3 days (five or six doses given daily), if 80-mg dose is tolerated and QT interval less than 500 msec, dosage maintained and patient discharged. Or hospitalized patient monitored closely to determine maintenance dosage while increasing to 120 mg b.i.d. for 3 days (five or six doses if daily dosing). Maximum: 160 mg b.i.d. if creatinine clearance exceeds 60 ml/min/ 1.73 m2.
Dosage Adjustment If 80-mg once or twice daily doesn't reduce frequency of atrial fibrillation relapses and is tolerated without excessive QT-interval prolongation (greater than 520 msec), dosage increased to 120 mg once or twice daily, depending on creatinine clearance. If 120-mg dose doesn't reduce frequency of early relapse and is tolerated using same criteria, dosage increased to 160 mg once or twice daily, depending on creatinine clearance.
Dosage Adjustment If QT interval is 520 msec or more, dosage reduced until it returns to less than 520 msec. If QT interval exceeds 520 msec with lowest maintenance dosage of 80 mg, drug stopped. If renal function deteriorates, daily dose reduced by half and given daily.
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Contraindications of Drug
Read contraindications if you want cheap Betapace (Sotalol) online.
Asthma, atrial arrhythmias (if baseline QT interval exceeds 450 msec or creatinine clearance is less than 40 ml/min/1.73 m2), cardiogenic shock, congenital or acquired QT syndromes, COPD, heart failure (unless it results from tachyarrhythmia that's treatable by sotalol), hypersensitivity to sotalol or its components, second- or third-degree atrioventricular block without functioning pacemaker, sinus bradycardia
Generic Drug Interactions
Drugs
allergen immunotherapy, allergenic extracts for skin testing: Increased risk of serious systemic adverse reaction or anaphylaxis
amiodarone: Additive depressant effect on conduction, negative inotropic effect anesthetics (hydrocarbon inhalation): Increased risk of myocardial depression and hypotension
antacids: Altered sotalol effectiveness
astemizole, class I antiarrhythmics, phenothiazines, terfenadine, tricyclic antidepressants: Prolonged QT interval, life-threatening torsades de pointes
beta blockers (other): Additive beta blockade
beta2-receptor stimulants: Decreased effectiveness of these drugs
calcium channel blockers, clonidine, diazoxide, guanabenz, reserpine and other anti-hypertensives: Additive antihypertensive effect and, possibly, other beta-blocking effects
cimetidine: Possibly impaired sotalol clearance
glucagon: Possibly blunted hyperglycemic response
insulin, oral antidiabetic drugs: Impaired glucose control, increased risk of hyperglycemia
lidocaine: Decreased lidocaine clearance, increased risk of lidocaine toxicity MAO inhibitors: Increased risk of significant hypertension
neuromuscular blockers: Possibly potentiated and prolonged neuromuscular blockade phenothiazines: Increased blood levels of both drugs
propafenone: Increased blood level and half-life of sotalol
sympathomimetics, xanthines: Possibly mutual inhibition of therapeutic effects
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Drugs Adverse Reactions
Central Nervous System: Anxiety, depression, dizziness, drowsiness, fatigue, insomnia, lethargy, nervousness, weakness
Cardiovascular: atrioventricular conduction disorders, bradycardia, heart failure, hypotension, peripheral vascular insufficiency
Eyes, Ears, Nose, And Throat: Nasal congestion
Endocrine: Hyperglycemia, hypoglycemia
Gastrointestinal: Abdominal pain, constipation, diarrhea, nausea, vomiting
Genitourinary: Sexual dysfunction
Musculoskeletal: Muscle weakness
Respiratory: Bronchospasm, dyspnea, wheezing
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Nursing Considerations for Generic Drugs
• Expect to obtain baseline creatinine clearance and QT interval before starting sotalol.
• Monitor blood pressure, apical and radial pulses, fluid intake and output, daily weight, respiratory rate, and circulation in limbs before and during sotalol therapy.
• If prescriber is stopping amiodarone, be aware that sotalol shouldn't be started until QT interval has returned to baseline because of possible adverse cardiac effects.
• Be aware that stopping sotalol abruptly may cause life-threatening reactions.
• Monitor serum electrolyte levels because drug can increase risk of torsades de pointes in patients with electrolyte imbalances, especially hypokalemia or hypomagnesemia.
• Assess carefully if patient has diabetes mellitus or thyrotoxicosis because they may mask hypoglycemia and hyperthyroidism.
Do I need a prescription to buy generic Betapace (Sotalol) in your online drug store?
No. You can buy Betapace (Sotalol) without a prescription!