Bupropion (Wellbutrin)
Class and Category of Drug
Before you buy Bupropion (Wellbutrin) online, read common information about the medication.
Chemical class: Aminoketone derivative
Therapeutic class: Antidepressant, smoking cessation adjunct
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Bupropion (Wellbutrin) online , you must read how it works.
To treat depression
E.R.Tablets (Wellbutrin SR)
Adults. Initial: 150 mg daily in morning for 3 days; then 150 mg b.i.d. and, after several wk, 200 mg b.i.d., as needed and tolerated. Maximum: 400 mg daily or 200 mg/dose.
E.R.Tablets (Wellbutrin XL)
Adults.
Initial: 150 mg daily in morning for at least 3 days; then 300 mg daily and, after 4 wk, 450 mg daily, as needed and tolerated. Maximum: 450 mg daily.
E.R.Tablets (Aplenzin)
Adults. Initial: 174 mg daily in the morning for 3 days. Then, if tolerated well, dosage increased to 348 mg daily in the morning.
After 4 wk of therapy, dosage increased to 522 mg daily in the morning, if needed.
Tablets
Adults.
Initial: 100 mg b.i.d., increased after 3 or more days to 100 mg t.i.d., as needed. Maximum: 450 mg daily or 150 mg/dose.
To aid in smoking cessation
Extended-Release Tablets
Adults. Initial: 150 mg daily for 3 days and then 150 mg b.i.d. for 7 to 12 wk. Maximum: 300 mg daily or 150 mg/dose.
To prevent seasonal major depressive episodes in patient with seasonal affective disorder
Extended-Release Tablets
Adults. Initial: 150 mg once daily in morning starting in autumn, increased after 1 wk to 300 mg once daily in morning, if tolerated and needed. Decreased to 150 mg once daily 2 wk before stopping in early spring.
Dosage Adjustment
For patients with severe hepatic cirrhosis, no more than 75 mg daily of Wellbutrin, 100 mg daily or 150 mg every other day of Wellbutrin SR, 150 mg every other day of Wellbutrin XL or Zyban, and 174 mg every other day of Aplenzin. In renal impairment, dosage or frequency decreased on an individual basis.
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Contraindications of Drug
Read contraindications if you want cheap Bupropion (Wellbutrin) online.
Anorexia, bulimia, use of another form of bupropion, hypersensitivity to bupropion or its components, seizure disorder, treatment requiring abrupt discontinuation of alcohol or sedatives (including benzodiazepines), use within 14 days of an MAO inhibitor
Generic Drug Interactions
Drugs
amantadine, levodopa: Increased adverse reactions to bupropion
carbamazepine, cimetidine, phenobarbital, phenytoin: Increased bupropion metabolism
clozapine, fluoxetine, haloperidol, lithium,loxapine, maprotiline, molindone, phenothiazines, thioxanthenes, trazodone, tricyclic antidepressants: Increased risk of major motor seizures
levodopa: Increased adverse bupropion effects
MAO inhibitors: Increased risk of acute bupropion toxicity
nicotine: Possibly increased blood pressure
warfarin: Possibly altered prothrombin time and INR; risk of hemorrhagic or thrombotic complications
Activities
alcohol use, recreational drug abuse: Lowered seizure threshold
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Drugs Adverse Reactions
Central Nervous System: Agitation, akathisia, anxiety, asthenia, CNS stimulation, coma, confusion, decreased concentration or memory, delusions, depression, dizziness, euphoria, fever, general or migraine headache, hallucinations, hostility, insomnia, irritability, mania, nervousness, paranoia, paresthesia, seizures, sleep disorder, somnolence, stroke, suicidal ideation, syncope, tremor, vertigo
Cardiovascular: Arrhythmias, chest pain, complete atrioventricular block, hypertension, MI, orthostatic hypotension, palpitations, phlebitis, tachycardia, vasodilation
Eyes, Ears, Nose, And Throat: Altered taste, amblyopia, blurred vision, dry mouth, hearing loss, increased ocular pressure, pharyngitis, sinusitis, taste perversion, tinnitus
Endocrine: Hyperglycemia, hypoglycemia, syndrome of inappropriate ADH secretion
Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, dysphagia, flatulence, gastrointestinal hemorrhage, gastrointestinal ulceration, hepatitis, increased appetite, intestinal perforation, nausea, pancreatitis, vomiting
Genitourinary: Urinary frequency and urgency, urinary tract infection, vaginal hemorrhage
Hematologic: Anemia, leukocytosis, leukopenia, lymphadenopathy, pancytopenia, thrombo-cytopenia
Musculoskeletal: Arthralgia, arthritis, muscle twitching, myalgia, rhabdomyolysis
Respiratory: Bronchospasm, cough, pulmonary embolism
Skin: Diaphoresis, exfoliative dermatitis, flushing, pruritus, rash, urticaria
Other: Angioedema, generalized pain, hot flashes, infection, serum sicknesslike reaction, weight loss
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Nursing Considerations for Generic Drugs
• Use cautiously in patients with renal impairment; drug is excreted by kidneys.
• Monitor children, adolescents, and depressed patients closely for worsened depression and increased suicide risk, especially when therapy starts or dosage changes.
• If patient takes bupropion for smoking cessation, watch for neuropsychiatric symptoms, including changes in behavior, hostility, agitation, depressed mood, suicidal ideation, and worsening of psychiatric illness. If present, notify prescriber immediately, begin safety measures, and expect to discontinue drug.
• To reduce seizure risk, allow at least 4 hours (tablets) or 8 hours (E.R. tablets) between doses.
• Use seizure precautions, especially in patients who take OTC stimulants or anorectics; use excessive alcohol or sedatives; are addicted to opioids, cocaine, or stimulants; take drugs that lower the seizure threshold; have a history of seizures, head trauma, or CNS tumors; have severe hepatic cirrhosis; or take insulin or an oral antidiabetic.
• Using transdermal nicotine with bupropion may cause hypertension. Watch closely.
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