Calan (Verapamil)
Class and Category of Drug
Before you buy Calan (Verapamil) online, read common information about the medication.
Chemical class: Phenylalkylamine derivative
Therapeutic class: Antianginal, antiarrhythmic, antihypertensive
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Calan (Verapamil) online , you must read how it works.
To treat chronic angina pectoris
Tablets (Verapamil)
Adults and adolescents age 15 and over. Initial: 80 to 120 mg t.i.d., increased every day or wk, as needed and prescribed. Maximum: 480 mg daily in divided doses. Infants and children up to age 15.4 to 8 mg/kg daily in divided doses.
To manage hypertension
E.R. Capsules (Verapamil Hydrochloride)
Adults and adolescents. Initial: 240 mg daily, increased every day or wk, as needed and prescribed. Maximum: 480 mg daily.
E.R.Tablets (Verapamil Hydrochloride)
Adults and adolescents. Initial: 180 mg daily, increased every day or wk, as needed and prescribed, according to following schedule: 240 mg daily in the morning; 180 mg every 12 hr or 240 mg in the morning and 120 mg in the evening; then 240 mg every 12 hr. Maximum: 480 mg daily in divided doses.
Tablets (Verapamil)
Adults and adolescents age 15 and over. Initial: 80 to 120 mg t.i.d., increased every day or wk, as needed and prescribed. Maximum: 480 mg daily in divided doses. Infants and children up to age 15. 4 to 8 mg/kg daily in divided doses.
To prevent or treat supraventricular tachycardia
Tablets (Verapamil)
Adults and adolescents age 15 and over. Initial: 80 to 120 mg t.i.d., increased every day or wk, as needed and prescribed. Maximum: 480 mg daily in divided doses.
Dosage Adjustment Initial P.O. dosage possibly reduced to 40 mg t.i.d. (120 mg daily for E.R. tablets or capsules) for elderly patients and those with impaired hepatic or left ventricular function.
Intravenous Injection (Verapamil Hydrochloride)
Adults and adolescents age 15 and over. Initial: 5 to 10 mg slowly over 2 min; then 10 mg, as prescribed, if response isn't adequate after 30 min. Children ages 1 to 15. Initial: 100 to 300 mcg/kg slowly over 2 min, up to maximum of 5 mg; then 10 mg, as prescribed, if response isn't adequate after 30 min. Infants up to age 1. Initial: 100 to 200 meg/ kg slowly over 2 min.
Dosage Adjustment Intravenous drug administered over 3 minutes in elderly patients.
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Incompatibilities
Don't mix intravenous verapamil with albumin, amphotericin B injection, hydralazine hydrochloride injection, nafcillin, or sulfamethoxazole and trimethoprim injection. Solutions with pH above 6.0 cause precipitation.
Contraindications of Drug
Read contraindications if you want cheap Calan (Verapamil) online.
Cardiogenic shock, concomitant use of beta blockers (with intravenous verapamil), hypersensi-tivity to verapamil or its components, hypotension, severe heart failure unless secondary to supraventricular tachycardia that responds to verapamil, severe left ventricular dysfunction, sick sinus syndrome or second- or third-degree heart block unless artificial pacemaker is in place, ventricular tachycardia (with intravenous verapamil)
Generic Drug Interactions
Drugs
alpha blockers, antihypertensives, general anesthetics (hydrocarbon), prazosin: Hypotensive effects
aspirin: Increased bleeding time beta blockers: Increased risk of heart failure, hypotension, and severe bradycardia calcium supplements: Decreased response to verapamil
carbamazepine, cyclosporine, theophylline, valproate: Increased risk of toxicity from these drugs
cimetidine: Decreased metabolism and increased blood level of verapamil clonidine: Increased risk of severe sinus bradycardia
cyclophosphamide, oncovin, procarbazine, prednissone (COPP) regimen; vindesine, adriamycin, cisplatin (VAC) regimen: Decreased verapamil absorption dantrolene: Increased risk of hyperkalemia and myocardial depression
digoxin: Increased blood digoxin level and risk of digitalis toxicity
disopyramide, flecainide: Additive negative inotropic effects
doxorubicin: Increase plasma doxorubicin level
erythromycin, ritonavir: Increased blood verapamil level
lithium: Increased risk of neurotoxicity
neuromuscular blockers: Prolonged recovery from neuromuscular blockade nonsteroidal anti-inflammatory drugs (NSAIDs),
sympathomimetics: Decreased anti-hypertensive effect of verapamil
paclitaxel: Decreased paclitaxel clearance
phenobarbital: Increased verapamil clearance
procainamide: Increased QT interval, additive negative inotropic effects protein-bound drugs (hydantoins, salicylates, sulfonamides, sulfonylureas, and warfarin and other oral anticoagulants): Altered blood levels of these drugs
quinidine: Increased risk of quinidine toxicity, increased QT interval, additive negative inotropic effects
rifampin: Decreased bioavailability of oral verapamil
telithromycin: Increased risk of bradyarrhythmias, hypotension, and lactic acidosis
Foods
grapefruit juice: Increased verapamil level
Activities
alcohol use: Increased blood alcohol level and prolonged CNS effects
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Drugs Adverse Reactions
Central Nervous System: Asthenia, confusion, disequilibrium, dizziness, equilibrium disorders, extrapyramidal reactions, fatigue, headache, insomnia, paresthesia, psychosis, shakiness, somnolence, stroke, syncope
Cardiovascular: Abnormal electrocardiogram, angina, atrioventricular conduction disorders, bradycardia, claudication, heart failure, hypertension, hypotension, MI, palpitations, peripheral edema, tachycardia, vasculitis
Eyes, Ears, Nose, And Throat: Blurred vision, dry mouth, tinnitus
Endocrine: Gynecomastia, hyperprolactinemia
Gastrointestinal: Constipation, diarrhea, elevated liver function test results, gastrointestinal distress, nausea
Genitourinary: Galactorrhea, impotence, increased urination, menstrual irregularities
Musculoskeletal: Arthralgia, muscle spasms
Respiratory: Dyspnea, pulmonary edema,
Skin: Alopecia, diaphroesis, ecchymosis, erythema multiforme, exanthema, flushing, hyperkeratosis, rash, Stevens-Johnson syndrome, urticaria
Other: Allergy aggravated
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Nursing Considerations for Generic Drugs
• Administer intravenous verapamil with compatible solutions, including Ringer's injection, D5W, or normal saline solution.
• Maintain continuous electrocardiogram monitoring and keep emergency resuscitative equipment and drugs readily available during intravenous therapy.
• Assess patient with hypertrophic cardiomyopathy or idiopathic hypertrophic subaortic stenosis for early development of hypotension and pulmonary edema because second-degree atrioventricular block and sinus arrest can result.
• Assess for bradycardia and hypotension, and notify prescriber if heart rate or blood pressure declines significantly.
• Disopyramide or flecainide shouldn't be given within 48 hours before or 24 hours after verapamil because additive negative inotropic effects can result.
• Institute measures to prevent constipation, including a high-fiber diet and a stool softener, as prescribed.
Do I need a prescription to buy generic Calan (Verapamil) in your online drug store?
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