Celebrex (Celecoxib)
Class and Category of Drug
Before you buy Celebrex (Celecoxib) online, read common information about the medication.
Chemical class: Diaryl-substituted pyrazole derivative
Therapeutic class: Anti-inflammatory, antirheumatic
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Celebrex (Celecoxib) online , you must read how it works.
To relieve signs and symptoms ofosteoarthritis
Capsules
Adults. 200 mg daily or 100 mg b.i.d.
To relieve signs and symptoms of rheumatoid arthritis
Capsules
Adults. 100 to 200 mg b.i.d.
To relieve signs and symptoms of juvenile rheumatoid arthritis
Capsules
Children age 2 and older weighing 10 to 25 kg (22 to 55 lb). 50 mg b.i.d. Children age 2 and older weighing more than 25 kg. 100 mg b.i.d.
To relieve pain from ankylosing spondylitis
Capsules
Adults. 200 mg daily or 100 mg b.i.d. Dosage increased to 400 mg daily or 200 mg b.i.d. after 6 weeks if needed.
As adjunct to reduce adenomatous colorectal polyps in patients with familial adenomatous polyposis
Capsules
Adults. 400 mg b.i.d.
To manage acute pain, to treat primary dysmenorrhea
Capsules
Adults. 400 mg, followed by 200 mg if needed, on 1st day. On subsequent days, 200 mg b.i.d. as needed.
Dosage Adjustment
Daily dosage reduced for patients with hepatic impairment. For those weighing less than 50 kg (110 lb), expect to start with lowest recommended dose. For patients who are poor CYP2C9 metabolizers, starting dosage should be half the lowest recommended dose.
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Generic Drug Mechanism of Action
Selectively inhibits the enzymatic activity of cyclooxygenase-2 (COX-2), the enzyme needed to convert arachidonic acid to prostaglandin. Prostaglandins are responsible for mediating the inflammatory response and causing local vasodilation, swelling, and pain. Prostaglandins also play a role in peripheral pain transmission to the spinal cord. By inhibiting COX-2 activity and prostaglandin production, this NSAID reduces inflammatory symptoms and relieves pain. Celecoxib's mechanism of action in reducing the number of colorectal polyps is unknown.
Contraindications of Drug
Read contraindications if you want cheap Celebrex (Celecoxib) online.
Allergic reaction (such as anaphylaxis or angioedema) to aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), or sulfonamide derivatives or history of aspirin-induced nasal polyps with bron-chospasm; hypersensitivity to celecoxib or its components; treatment of perioperative pain after coronary artery bypass graft surgery
Generic Drug Interactions
Drugs
ACE inhibitors, angiotensin II receptor antagonists: Decreased antihypertensive effect of ACE inhibitors and angiotensin II receptor antagonists, increased risk of renal failure
aspirin: Increased risk of gastrointestinal ulceration and other gastrointestinal complications
fluconazole: Increased blood celecoxib level
furosemide, thiazide diuretics: Reduced diuretic effects of these drugs, increased risk of renal failure
lithium: Possibly elevated blood lithium level
warfarin: Possibly increased prothrombin time and risk of bleeding
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Drugs Adverse Reactions
Central Nervous System: Asceptic meningitis, cerebral hemorrhage, depression, dizziness, fever, headache, insomnia, ischemic stroke, stroke, suicidal ideation, syncope, transient ischemic attacks, vertigo
Cardiovascular: Aortic valve incompetence, chest pain, congestive heart failure, deep vein thrombosis, fluid retention, hypertension, MI, palpitations, peripheral edema or gangrene, sinus bradycardia, tachycardia, thrombosis, unstable angina, vasculitis, ventricular fibrillation, ventricular hypertrophy
Eyes, Ears, Nose, And Throat: Conjunctival hemorrhage, deafness, labyrinthitis, nasopharyngitis, pharyngitis, rhinitis, sinusitis, vitreous floaters
Endocrine: Hyperglycemia, hypoglycemia
Gastrointestinal: Abdominal pain, diarrhea, elevated liver function test results, esophageal perforation, flatulence, gastrointestinal bleeding or ulceration, hepatic failure, ileus, indigestion, jaundice, nausea, pancreatitis, perforation of stomach or intestine, vomiting
Genitourinary: Acute renal failure, interstitial nephritis, ovarian cyst, proteinuria, urinary tract infection, urinary incontinence
Hematologic: Agranulocytosis, aplastic anemia, decreased hematocrit and hemoglobin, leukopenia, pancytopenia, prolonged APTT, thrombocytopenia
Musculoskeletal: Arthralgia, back pain, elevated serum CK level, epicondylitis, tendon rupture
Respiratory: Bronchospasm, cough, dyspnea, pneumonia, pulmonary embolism, upper respiratory tract infection
Skin: Erythema multiforme, exfoliative dermatitis, phototoxicity, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria
Other: Anaphylaxis, angioedema, hyperkalemia, hypernatremia, hyponatremia, sepsis
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Celecoxib
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
Proprietary Preparations
Argentina: Algybrex; Celebrex; Celemax; Cloxib; Coxel; Coxtenk; Niflam; Radicacine; Tisorek;
Australia: Celebrex;
Austria: Celebrex; Solexa;
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Belgium: Celebrex;
Brazil: Celebra;
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Venezuela: Celebrex; Cexb.
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