Chloramphenicol (Chloromycetin)
Class and Category of Drug
Before you buy Chloramphenicol (Chloromycetin) online, read common information about the medication.
Chemical class: Dichloroacetic acid derivative
Therapeutic class: Antibiotic
Pregnancy category: Not rated
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Drug Indications and Dosages
Before purchase Chloramphenicol (Chloromycetin) online , you must read how it works.
To treat serious infections for which less potentially dangerous drugs are ineffective or contraindicated
Intravenous Infusion
Adults. 12.5 mg/kg every 6 hr. Maximum: 4 g daily.
Children. 50 to 75 mg/kg daily in divided doses every 6 hr.
Full-term infants age 2 weeks and over.12.5 mg/kg every 6 hr or 25 mg/kg every 12 hr.
Preterm and full-term infants up to age 2 weeks. 6.25 mg/kg every 6 hr.
To treat hacteremia or meningitis
Intravenous Infusion
Children. 50 to 100 mg/kg daily in divided doses every 6 hr.
Dosage Adjustment
Dosage limited to 25 mg/kg daily for infants and children with immature metabolic processes.
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Contraindications of Drug
Read contraindications if you want cheap Chloramphenicol (Chloromycetin) online.
Hypersensitivity to chloramphenicol or its components
Generic Drug Interactions
Drugs
alfentanil: Prolonged alfentanil effect
barbiturates: Increased blood barbiturate level; decreased chloramphenicol level blood-dyscrasia-causing drugs (such as captopril and cephalosporins), bone marrow depressants (including colchicine and methotrexate): Increased bone marrow depression
chlorpropamide, tolbutamide: Increased hypoglycemic effects
clindamycin, erythromycin, lincomycin: Decreased antibacterial effects of these drugs
cyclophosphamide: Decreased or delayed activation of cyclophosphamide, increased bone marrow depression
hepatic enzyme inducers (including rifampin): Decreased chloramphenicol level
hydantoins: Increased blood hydantoin level, possibly resulting in toxicity; increased or decreased blood chloramphenicol level
iron salts: Increased serum iron level
oral anticoagulants: Enhanced anticoagulant action
oral contraceptives containing estrogen: Decreased contraceptive effect with prolonged chloramphenicol use
penicillins: Decreased penicillin activity; synergistic effects with treatment of certain microorganisms
vitamin B12: Antagonized hematopoietic response to vitamin B12
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Drugs Adverse Reactions
Central Nervous System: Confusion, delirium, depression, fever, headache, peripheral neuropathy
Cardiovascular: Gray syndrome in neonates
Eyes, Ears, Nose, And Throat: Optic neuritis
Gastrointestinal: Diarrhea, nausea, vomiting
Hematologic: Aplastic anemia, bone marrow depression, granulocytopenia, hypoplastic anemia, leukopenia, reticulocytopenia, thrombocytopenia
Skin: Rash
Other: Anaphylaxis, angioedema
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Nursing Considerations for Generic Drugs
As appropriate and ordered, obtain specimen for culture and sensitivity testing before starting chloramphenicol therapy.
Keep in mind that chloramphenicol should never be used to treat minor infections or as prophylaxis because of its many serious toxicities.
Repeated courses of therapy should be avoided because of the risk of serious adverse reactions.
For intravenous use, prepare a 10% solution by adding 10 ml sterile water for injection or D5W to each 1-g vial. Administer over at least 1 minute.
Know that diluted intravenous solution is stable for 24 to 48 hours when stored at room temperature or refrigerated. Don't use if cloudy.
Assess patient for fever, sore throat, tiredness, unusual bleeding, or ecchymosis; these may indicate a blood dyscrasia.
Perform neurologic assessments regularly, looking for signs of peripheral neuropathy.
Monitor blood chloramphenicol level as appropriate. Keep in mind that therapeutic peak levels are 10 to 20 mcg/ml and trough levels are 5 to 10 mcg/ml.
Monitor CBC and platelet and reticulocyte counts as ordered to detect signs of blood dyscrasia. Notify prescriber immediately about abnormal results.
WARNING If early signs of gray syndrome appear (failure to eat, pallor, cyanosis, abdominal distention, irregular respirations, and vasomotor collapse), notify pre-scriber and be prepared to stop drug immediately.
Do I need a prescription to buy generic Chloramphenicol (Chloromycetin) in your online drug store?
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