Colchicine (Colcrys)
Class and Category of Drug
Before you buy Colchicine (Colcrys) online, read common information about the medication.
Chemical class: Colchicum alkaloid derivative
Therapeutic class: Antigout, anti-inflammatory
Pregnancy category: C (oral form), D (parent eral forms)
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Drug Indications and Dosages
Before purchase Colchicine (Colcrys) online , you must read how it works.
To prevent gouty arthritis attacks
Tablets (Colcrys)
Adults and adolescents age 16 and over.
0.5 to 0.6 mg once or twice daily. Maximum: 1.2 mg daily.
Intravenous Infusion or Injection
Adults. 0.5 to 1 mg once or twice daily. Maximum: 4 mg daily.
To treat acute gouty arthritis
Tablets (Colcrys)
Adults.
Initial: 1.2 mg at first sign of flare;then 0.6 mg 1 hr later. Maximum: 1.8 mg over a 1-hr period.
Intravenous Infusion or Injection
Adults. 2 mg over 2 to 5 min; then 0.5 mg every 6 hr or 1 mg every 6 to 12 hr until pain decreases. Maximum: 4 mg daily.
Dosage Adjustment
For elderly patients, maximum intravenous dosage reduced to 2 mg/24 hr; maximum oral dosage to 2 mg/24 hr.
After initial intravenous course, elderly patient should receive no form of colchicine for 21 days. If treatment of a gout flare occurs during prophylactic treatment, dosage shouldn't exceed 1.2 mg at the first sign of flare, followed by 0.6 mg 1 hour later, and then prophylactic dose resumed 12 hr later.
For patient taking strong CYP3A4 inhibitor (atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin), moderate CYP3A4 inhibitor (amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, verapamil), or P-gp inhibitor (cyclosporine, ranolazine), dosage usually halved and not repeated for 3 days.
For patient with moderate to severe renal impairment, dosage adjusted on individual basis. For patient with severe hepatic impairment receiving colchicine prophylacticly, dosage decreased on individual basis. For patient with severe hepatic impairment receiving colchicine treatment for acute gout flare but not prophylaxis, dosage not adjusted but treatment course shouldn't be repeated more than once very 2 weeks.
To treat familial Mediterranean fever (FMF)
Tablets (Colcrys)
Adults and adolescents ages 12 and over. 1.2 mg to 2.4 mg daily, with daily total divided into two doses, if desired.
Children ages 6 to 12.
0.9 mg to 1.8 mg daily, with daily total divided into two doses, if desired.
Children ages 4 to 6.0.3 mg to 1.8 mg daily, with daily total divided into two doses, if desired.
Contraindications of Drug
Read contraindications if you want cheap Colchicine (Colcrys) online.
Blood dyscrasias; hypersensitivity to colchicine or its components; serious cardiac, gastrointestinal, hepatic, or renal disorders
Incompatibilities
Don't combine colchicine with bacteriostatic agents, any solution or injection that contains D5W, and any other solution that may change colchicine's pH because precipitation may occur.
Generic Drug Interactions
Drugs
anticoagulants, such as heparin; platelet aggregation inhibitors, such as aspirin; thrombolytics, such as alteplase: Increased risk of gastrointestinal ulcers or hemorrhage
antineoplastics: Possibly increased serum uric acid level and decreased therapeutic effectiveness of colchicine cyclosporine: Increased cyclosporine level moderate CYP3A4 inhibitors, such as amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, verapamil: Increased risk of colchicine toxicity
NSAIDs, such as phenylbutazone: Possibly increased risk of bone marrow depression, gastrointestinal bleeding, leukopenia, thrombocytopenia
strong CYP3A4 inhibitors, such as atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nefinavir, ritonavir, saquinavir, telithromycin: Increased risk of colchicine toxicity
P-gp inhibitors, such as cyclosporine, ranolazine: Increased risk of colchicine toxicity
vitamin B12: Possibly impaired absorption of and increased dosage requirements for vitamin B12
Activities
alcohol use: Increased risk of adverse gastrointestinal effects
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Drugs Adverse Reactions
Central Nervous System: Peripheral neuropathy
Cardiovascular: Arrhythmias (I.V. form)
Gastrointestinal: Abdominal pain, anorexia, diarrhea, nausea, vomiting
Hematologic: Agranulocytosis, aplastic anemia, thrombocytopenia
Musculoskeletal: Myopathy
Skin: Alopecia, rash
Other: Injection site pain and tenderness, median nerve neuritis in affected arm, and skin and soft-tissue necrosis if extravasation occurs (I.V. form)
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Nursing Considerations for Generic Drugs
• Patients receiving prophylactic treatment for gout and who have hepatic impairment or are being treated with CYP3A4 inhibitors shouldn't receive colchicine for acute gout flares.
WARNING Avoid subcutaneous or intramuscular administration of colchicine because these routes may cause tissue necrosis and sloughing. To prevent extravasation, make sure intravenous catheter is patent and correctly positioned before giving drug. Throughout therapy, check intravenous injection site often for pain, tenderness, and skin peeling. Consult prescriber about switching to oral form.
WARNING To reduce risk of toxicity, avoid giving colchicine by any route within 7 days after full intravenous course (4 mg). If patient takes any drug that increases risk of colchicine toxicity, expect to wait 3 days after oral therapy before starting second oral course. Elderly or debilitated patients and those with a history of cardiac disease or impaired renal or hepatic function are at increased risk for cumulative toxicity.
• Dilute intravenous form with 10 to 20 ml of normal saline solution. Or, give colchicine into a large vein through an intravenous line with normal saline solution infusion.
• Administer intravenous form over 2 to 5 minutes.
• Expect to monitor CBC and platelet and reticulocyte counts at baseline and every 3 months after therapy starts.
• Notify prescriber immediately and expect to stop colchicine if patient develops evidence of toxicity, such as abdominal pain, diarrhea, nausea, or vomiting.
Do I need a prescription to buy generic Colchicine (Colcrys) in your online drug store?
No. You can buy Colchicine (Colcrys) without a prescription!
