Compazine (Prochlorperazine)
Class and Category of Drug
Before you buy Compazine (Prochlorperazine) online, read common information about the medication.
Chemical class: Phenothiazine, piperazine
Therapeutic class: Antianxiety, antiemetic, antipsychotic
Pregnancy category: Not rated
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Drug Indications and Dosages
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To control nausea and vomiting related to surgery
Intravenous Infusion or Injection
(Prochlorperazine Edisylate)
Adults and adolescents. 5 to 10 mg at a rate not to exceed 5 mg/ml 15 to 30 min
Adults and adolescents. 5 to 10 mg t.i.d. or q.i.d., increased gradually every 2 to 3 days, as needed and tolerated. Maximum: 150 mg daily.
Children ages 2 to 12.2.5 mg b.i.d. or t.i.d. Maximum: On day 1, 10 mg for all children; thereafter, 25 mg daily for children ages 6 to 12, 20 mg daily for children ages 2 to 6.
Tablets (Prochlorperazine Maleate)
Adults and adolescents. 5 to 10 mg t.i.d. or q.i.d., increased gradually every 2 to 3 days, as needed and tolerated. Maximum: 150 mg daily.
I.M. Injection (Prochlorperazine Edisylate)
Adults and adolescents. Initial: 10 to 20 mg, repeated every 2 to 4 hr, as prescribed, to bring symptoms under control (usually 3 to 4 doses). Maintenance: 10 to 20 mg every 4 to 6 hr. Maximum: 200 mg daily.
Children ages 2 to 12.132 mcg/kg/dose on day 1; then increased as needed. Maximum: On day 1, 10 mg for all children; thereafter, 25 mg daily for children ages 6 to 12, 20 mg/day for children ages 2 to 6.
To treat anxiety short-term
E.R. Capsules (Prochlorperazine Maleate)
Adults and adolescents. 15 mg daily in the morning, or 10 mg every 12 hr. Maximum: 20 mg/day for no longer than 12 wk.
Oral Solution, Tablets (Prochlorperazine Edisylate)
Adults and adolescents. 5 mg t.i.d. or q.i.d. Maximum: 20 mg daily for no longer than 12 wk.
Intravenous Infusion or Injection
(Prochlorperazine Edisylate)
Adults and adolescents. 2.5 to 10 mg at no more than 5 mg/min. Maximum: 40 mg daily.
I.M. Injection (Prochlorperazine Edisylate)
Adults and adolescents. 5 to 10 mg every 3 to 4 hr, p.r.n.
Dosage Adjustment
Initial dose usually reduced and subsequent dosage increased more gradually for elderly, emaciated, and debilitated patients.
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Incompatibilities
Don't mix prochlorperazine in same syringe with other drugs. Precipitate may form when prochlorperazine edisylate is mixed in same syringe with morphine surf ate.
Contraindications of Drug
Read contraindications if you want cheap Compazine (Prochlorperazine) online.
Age less than 2 years, blood dyscrasias, bone marrow depression, cerebral arteriosclerosis, coma, coronary artery disease, hepatic dysfunction, hypersensitivity to phenothiazines, myeloproliferative disorders, pediatric surgery, severe CNS depression, severe hypertension or hypotension, subcortical brain damage, use of large quantities of CNS depressants, weight less than 9 kg (20 lb)
Generic Drug Interactions
Drugs
aluminum- or magnesium-containing antacids, antidiarrheals (adsorbent): Possibly inhibited absorption of oral prochlorperazine
amantadine, anticholinergics, antidyskinetics, antihistamines: Possibly intensified anticholinergic adverse effects, increased risk of prochlorperazine-inducedhyperpyretic effect
amphetamines: Decreased stimulant effect of amphetamines, decreased antipsychotic effect of prochlorperazine anticonvulsants: Lowered seizure threshold antithyroid drugs: Increased risk of agranulocytosis
apomorphine: Possibly decreased emetic response to apomorphine, additive CNS depression
appetite suppressants: Possibly antagonized anorectic effect of appetite suppressants (except for phenmetrazine)
astemizole, cisapride, disopyramide, erythromycin, pimozide, probucol, procainamide: Additive QT interval prolongation, increased risk of ventricular tachycardia
beta blockers: Increased risk of additive hypotensive effects, irreversible retinopathy, arrhythmias, and tardive dyskinesia
bromocriptine: Decreased effectiveness of bromocriptine
* For antipsychotic effects; unknown for other indications.
CNS depressants: Additive CNS depression
dopamine: Possibly antagonized peripheral vasoconstriction (high doses of dopamine) ephedrine, epinephrine: Decreased vasopressor effects of these drugs
hepatotoxic drugs: Increased risk of hepatotoxicity
hypotension-producing drugs: Possibly severe hypotension with syncope levodopa: Inhibited antidyskinetic effect of levodopa
lithium: Reduced absorption of oral prochlorperazine, increased lithium excretion, increased extrapyramidal effects, possibly masking of early symptoms of lithium toxicity
MAO inhibitors, maprotiline, tricyclic antidepressants: Possibly prolonged and intensified anticholinergic and sedative effects, increased antidepressant level, inhibited prochlorperazine metabolism, increased risk of neuroleptic malignant syndrome
mephentermine: Possibly antagonized antipsychotic effect of prochlorperazine and vasopressor effect of mephentermine
metrizamide: Increased risk of seizures
opioid analgesics: Increased risk of CNS and respiratory depression, orthostatic hypotension, severe constipation, urine retention
ototoxic drugs: Possibly masking of some symptoms of ototoxicity, such as dizziness, tinnitus, and vertigo
phenytoin: Possibly inhibited phenytoin metabolism, increased risk of phenytoin toxicity
thiazide diuretics: Possibly potentiated hyponatremia and water intoxication
Activities
alcohol use: Additive CNS depression
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Drugs Adverse Reactions
Central Nervous System: Akathisia, altered temperature regulation, dizziness, drowsiness, extrapyramidal reactions (such as dystonia, pseudoparkinsonism, tardive dyskinesia)
Cardiovascular: Hypotension, orthostatic hypotension, tachycardia
Eyes, Ears, Nose, And Throat: Blurred vision, dry mouth, nasal congestion, ocular changes, pigmentary retinopathy
Endocrine: Galactorrhea, gynecomastia
Gastrointestinal: Constipation, epigastric pain, nausea, vomiting
Genitourinary: Dysuria, ejaculation disorders, menstrual irregularities, urine retention
Skin: Decreased sweating, photosensitivity, pruritus, rash
Other: Weight gain
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Nursing Considerations for Generic Drugs
Prochlorperazine shouldn't be used to treat dementia-related psychosis in the elderly because of increased mortality risk.
Avoid contact between skin and solution forms of prochlorperazine because contact dermatitis could result.
Inject intramuscular form slowly, deep into upper outer quadrant of buttocks. Keep patient supine for 30 minutes after injection to minimize hypotensive effects.
Rotate intramuscular injection sites to prevent irritation and sterile abscesses.
Be aware that intravenous form may be given undiluted as injection or diluted in isotonic solution as infusion (mesylate form requires dilution in at least 1 L). Both forms should be given at no more than 5 mg/minute.
Protect prochlorperazine from light.
Parenteral solution may develop slight yellowing that won't affect potency. Don't use if discoloration is pronounced or precipitate is present.
Expect antipsychotic effects to occur in 2 to 3 weeks, although range is days to months.
WARNING Monitor closely for numerous adverse reactions that may be serious.
Adverse effects may occur up to 12 weeks after discontinuation of E.R. capsules.
Remember it if you buying Compazine (Prochlorperazine) online.
Prochlorperazine
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Prochlorperazine Buccal Tablets; Prochlorperazine Injection; Prochlorperazine Oral Solution; Prochlorperazine Tablets;
The United States Pharmacopeia 31, 2008: Prochlorperazine Edisylate Injection; Prochlorperazine Maleate Tablets; Prochlorperazine Oral Solution; Prochlorperazine Suppositories.
Proprietary Preparations
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Multi-ingredient
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