Cordarone (Amiodarone)
Class and Category of Drug
Before you buy Cordarone (Amiodarone) online, read common information about the medication.
Chemical class: Iodinated benzofuran derivative
Therapeutic class: Class III antiarrhythmic
Pregnancy category: D
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Drug Indications and Dosages
Before purchase Cordarone (Amiodarone) online , you must read how it works.
To treat life-threatening, recurrent ventricular fibrillation and hemodynamically unstable ventricular tachycardia when these arrhythmias don't respond to other drugs or when patient can't tolerate other drugs
Tablets
Adults. Toading: 800 to 1,600 mg daily in divided doses for 1 to 3 wk. Maintenance: 600 to 800 mg daily in divided doses for 1 mo; then if cardiac rhythm is stable, 400 mg daily in 1 or 2 doses. Use lowest possible dose.
Intravenous Infusion
Adults. Toading: 150 mg over 10 min (15 mg/ min) followed by 360 mg infused over 6 hr (1 mg/min). Maintenance: 540 mg infused over 18 hr (0.5 mg/min); then after the first 24 hr, 720 mg infused over 24 hr (0.5 mg/ min), continued up to 2 to 3 wk, as needed. Rate may be increased in first 24 hr, if needed, but initial infusion rate shouldn't exceed 30 mg/min. Change to oral form as soon as possible.
To treat breakthrough episodes of ventricular fibrillation or hemodynamically unstable ventricular tachycardia
I.V. Infusion (NEXTERONE) Adults. 150 mg mixed in 100 ml D5W and infused over 10 min (15 mg/min).
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Incompatibilities
Amiodarone is incompatible with heparin. To prevent precipitation, don't add amiodarone admixed with D5W to aminophylline 4 mg/ml, cefamandole nafate, cefazolin sodium, or mezlocillin sodium, and don't mix amiodarone 3 mg/ml with sodium bicarbonate. Also, don't use evacuated glass containers for admixing because precipitation may occur.
Contraindications of Drug
Read contraindications if you want cheap Cordarone (Amiodarone) online.
Bradycardia that causes syncope (unless pacemaker present), cardiogenic shock, hypersensitivity to amiodarone or its components, hypokalemia, hypomagnesemia,
sinoatrial node dysfunction, second- and third-degree atrioventricular block (unless pacemaker present)
Generic Drug Interactions
Drugs
anticoagulants: Increased anticoagulant response and possibly serious bleeding
azole antifungals, fluoroquinolones, macrolide antibiotics: Increased risk of prolonged QT interval and life-threatening arrhythmias
beta blockers: Increased serum levels of beta blockers with increased risk of atrioventricular block, hypotension, and bradycardia
calcium channel blockers: Increased serum levels of these drugs and increased risk of atrioventricular block, bradycardia, and hypotension
cholestyramine, phenytoin, rifampin, St. John's wort: Decreased amiodarone level
cimetidine: Increased amiodarone level
clopidogrel: Increased risk of ineffective inhibition of platelet aggregation
cyclosporine: Increased cyclosporine level
dextromethorphan, methotrexate, phenytoin: Increased serum levels of these drugs and increased risk of toxicity if amiodarone is taken orally for more than 2 weeks
digoxin: Increased serum digoxin level and risk of digitalis toxicity
diltiazem, propranolol, verapamil: Increased risk of hemodynamic and electrophysiologic abnormalities
disopyramide: Increased serum disopyramide level with QT prolongation and increased risk of arrhythmias
fentanyl: Increased serum fentanyl level with increased risk of bradycardia, decreased cardiac output, and hypotension
flecainide: Increased serum flecainide level
HMG-CoA reductase inhibitors such as atorvastatin and simvastatin: Increased risk of myopathy and rhabdomyolysis
hydantoins: Increased serum hydantoin level with long-term use and reduced serum amiodarone level
lidocaine: Increased serum lidocaine level and risk of seizures and bradycardia
loratadine, trazodone: Increased risk of QT-interval prolongation and torsades de pointes
potassium- and magnesium-depleting drugs: Increased risk of hypokalemia and hypo-magnesemia
procainamide: Increased serum pro-cainamide orN-acetylprocainamide level
quinidine: Increased serum quinidine level with risk of life-threatening arrhythmias
ritonavir: Increased serum amiodarone level with increased risk of cardiotoxicity theophylline: Increased serum theophylline level; increased risk of theophylline toxicity
warfarin: Increased prothrombin time and risk of bleeding
Foods grapefruit juice: Increased amiodarone level
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Drugs Adverse Reactions
Central Nervous System: Abnormal gait, ataxia, confusion, delirium, demyelinating polyneuropathy, disorientation, dizziness, fatigue, fever, hallucinations, headache, insomnia, involuntary motor activity, lack of coordination, malaise, paresthesia, parkinsonian symptoms, peripheral neuropathy, pseudotumor cerebri, sleep disturbances, tremor
Cardiovascular: Arrhythmias (including bradycardia, electromechanical dissociation, torsades de pointes, and ventricular tachycardia or fibrillation), cardiac arrest, cardiogenic shock, edema, heart failure, hypotension, vasculitis
Eyes, Ears, Nose, And Throat: Abnormal salivation, abnormal taste and smell, blurred vision, corneal microdeposits, dry eyes, halo vision, lens opacities, macular degeneration, optic neuritis, optic neuropathy, papilledema, permanent blindness, photophobia, scotoma
Endocrine: Hyperthyroidism, hypothyroidism, syndrome of inappropriate ADH secretion, thyroid cancer
Gastrointestinal: Abdominal pain, anorexia, cirrhosis, constipation, diarrhea, elevated liver function test results, hepatitis, nausea, pancreatitis, vomiting
Genitourinary: Acute renal failure, decreased libido, epididymitis, impotence
Hematologic: Agranulocytosis, aplastic or hemolytic anemia, coagulation abnormalities, neutropenia, pancytopenia, spontaneous bruising, thrombocytopenia
Musculoskeletal: Muscle weakness, myopathy, rhabdomyolysis
Respiratory: Acute respiratory distress syndrome; bronchospasm; eosinophilic pneumonia; infiltrates that lead to dyspnea, cough, hemoptysis, hypoxia, pulmonary fibrosis, pulmonary alveolar hemorrhage, pulmonary interstitial pneumonitis, crackles, and wheezing; pleural effusion; pleuritis; pneumonia; respiratory arrest or failure
Skin: Alopecia, bluish gray pigmentation, eczema, erythema multiforme, exfoliative
dermatitis, flushing, photosensitivity, pruritus, rash, skin cancer, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria
Other: Anaphylactic shock, angioedema
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Do I need a prescription to buy generic Cordarone (Amiodarone) in your online drug store?
No. You can buy Cordarone (Amiodarone) without a prescription!
