Crestor (Rosuvastatin) - Blood Pressure/Cholesterol
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Top » Catalog » Blood Pressure/Cholesterol » Crestor (Rosuvastatin)


Crestor (Rosuvastatin)

$44.29


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Crestor (Rosuvastatin)

Class and Category of Drug

Before you buy Crestor (Rosuvastatin) online, read common information about the medication.

Chemical class: HMG-CoA reductase inhibitor

Therapeutic class: Antihyperlipidemic

Pregnancy category: X

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Drug Indications and Dosages

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To treat hyperlipidemia, mixed dyslipidemia, hypertriglyceridemia, and primary dysbetalipoproteinemia (Type III hyperlipoproteinemia); to slow the progression of atherosclerosis

Tablets

Adults with LDL-C level of 190 mg/dl or below. Initial: 10 mg daily, increased every 2 to 4 wk, as needed. Maximum: 40 mg daily.

Adults with LDL-C level greater than 190 mg/dl. Initial: 20 mg daily, increased every 2 to 4 wk, as needed. Maximum: 40 mg daily.

To treat homozygous familial hypercholesterolemia

Tablets

Adults. Initial: 20 mg daily, increased every 2 to 4 wk, as needed. Maximum: 40 mg daily.

To treat heterozygous familial hypercholesterolemia

Tablets

Children age 10 and over and adolescents at least 1 year post-menarche. 5 to 20 mg daily, increased q 4 wk, as needed. Maximum: 20 mg daily.

Dosage Adjustment For patients taking cyclosporine, dosage shouldn't exceed 5 mg daily. For Asian patients, initial dosage should be limited to 5 mg daily. For patients taking gemfibrozil or combined lopinavir and ritonavir, 10 mg daily. For patients with severe renal impairment (creatinine clearance greater than 30 ml/min/ 1.73 m2) who aren't having hemodialysis, dosage should start at 5 mg daily but not exceed 10 mg daily. For patients taking niacin or fenofbrate, dosage reduction should be considered.

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Generic Drug Interactions

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Drugs

antacids: Decreased blood rosuvastatin level if given within 2 hours of rosuvastatin cyclosporine, gemfibrozil, lopinavir/ritonavir, niacin, other lipid-lowering drugs: Increased rosuvastatin level and risk of myopathy oral contraceptives: Increased blood ethinyl estradiol and norgestrel levels warfarin: Increased INR

Drugs Adverse Reactions

Central Nervous System: Asthenia, depression, dizziness, headache, hypertonia, insomnia, memory loss, paresthesia

Cardiovascular: Chest pain, hypertension, peripheral edema

Eyes, Ears, Nose, And Throat: Pharyngitis, rhinitis, sinusitis

Endocrine: Thyroid function abnormalities

Gastrointestinal: Abdominal pain, constipation, diarrhea, elevated liver function test results, gastroenteritis, hepatic failure, hepatitis, jaundice, nausea, pancreatitis

Genitourinary: Acute renal failure, proteinuria, urinary tract infection

Musculoskeletal: Arthralgia, arthritis, back pain, myalgia, myopathy, rhabdomyolysis

Respiratory: Bronchitis, increased cough

Skin: Rash, urticaria

Other: Angioedema, flulike symptoms, generalized pain, infection

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Nursing Considerations for Generic Drugs

• Use rosuvastatin cautiously in patients who consume large quantities of alcohol or have a history of liver disease because drug is contraindicated in patients with active liver disease or unexplained persistent elevations of transaminase levels.

• Also use cautiously in patients with risk factors for myopathy, such as renal impairment, advanced age, and hypothyroidism.

• Obtain baseline liver function test results and expect to monitor them every 3 months for abnormal elevations. Notify prescriber if elevations occur. If alanine aminotransferase or aspartate aminotransferase levels increase to more than three times the normal range, expect dosage to be reduced or drug discontinued.

• Monitor serum lipoprotein level, as ordered, to evaluate response to therapy.

• Expect rosuvastatin to be temporarily withheld if patient develops any condition that may be related to myopathy or that predisposes her to renal failure, such as sepsis, hypotension, major surgery, trauma, uncontrolled seizures, or severe metabolic, endocrine, or electrolyte disorders.

• Notify prescriber if proteinuria or hematuria appears on patient's routine urinalysis because rosuvastatin dosage may need to be reduced.

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Rosuvastatin

Preparations

International Brand Drug Names

The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.


Proprietary Preparations


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