Cyklokapron (Lysteda)
Class and Category of Drug
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Chemical class: Synthetic lysine amino acid derivative
Therapeutic class: Antifibrinolytic
Pregnancy category: B
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Drug Indications and Dosages
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To treat cyclic heavy menstrual bleeding
Tablets
Adults. 1,300 mg three times daily for a maximum of 5 days during monthly menstruation
Dosage Adjustment
For patient with a serum creatinine level above 1.4 mg/dl but equal to or less than 2.8 mg/dl, 1,300 mg two times a day for a maximum of 5 days during menstruation; for patient with a serum creatinine level above 2.8 mg/dl but equal to or less than 5.7 mg/dl, 1,300 mg once daily for a maximum of 5 days during menstruation; for patient with a serum creatinine level above 5.7 mg/dl, 650 mg once daily for a maximum of 5 days during menstruation.
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Contraindications of Drug
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Active thromboembolic disease; history or intrinsic risk of thrombosis orthromboembolism, including retinal vein or artery occlusion; hypersensitivity to tranexamic acid or its components
Generic Drug Interactions
Drugs
anti-inhibitor coagulant concentrates, factor IX complex concentrates, hormonal contraceptives: Increased thrombotic risk tissue plasminogen activators: Possibly decreased effectiveness of both tranexamic acid and the tissue plasminogen activator tretinoin (oral): Possibly exacerbation of the pro-coagulant effect of tretinoin
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Drugs Adverse Reactions
Central Nervous System: Cerebral thrombosis, dizziness, fatigue, headache, migraine
Cardiovascular: Deep vein thrombosis
Eyes, Ears, Nose, And Throat: Central retinal artery and vein obstruction, feeling of throat tightness, impaired color vision, ligneous conjunctivitis, nasal and sinus congestion, sinusitis, visual abnormalities
Gastrointestinal: Abdominal pain, diarrhea, nausea, vomiting
Genitourinary: Acute renal cortical necrosis
Hematologic: Anemia
Musculoskeletal: Arthralgia, back pain, muscle cramps and spasms, myalgia
Respiratory: Dyspnea, pulmonary embolism, respiratory congestion,
Skin: Allergic skin reactions, facial flushing
Other: Anaphylaxis, multiple allergies including seasonal
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Nursing Considerations for Generic Drugs
• Tranexamic acid therapy isn't recommended for women who use hormonal contraceptives or who take factor IX complex concentrates or anti-inhibitor coagulant concentrates because of the increased risk of thromboembolism.
• Use tranexamic acid cautiously in patients with acute promyelocytic leukemia taking oral tretinoin for remission induction because of possible exacerbation of the pro-coagulant effect of tretinoin.
• Cerebral edema and cerebral infarction may occur in women taking tranexamic acid if a subarachnoid hemorrhage occurs.
WARNING Monitor patient closely for allergic reactions to tranexamic acid such as dyspnea, a feeling of throat tightness, and facial flushing that may require emergency medical treatment.
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