Decadron (Dexamethasone), Rinadex Compuesto
Class and Category of Drug
Before you buy Decadron (Dexamethasone) online, read common information about the medication.
Chemical class: Synthetic adrenocortical steroid
Therapeutic class: Anti-inflammatory, diagnostic aid, immunosuppressant
Pregnancy category: C
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Drug Indications and Dosages
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To treat endocrine disorders, such as congenital adrenal hyperplasia, hypercalcemia associated with cancer, and nonsuppurative thyroiditis; acute episodes or exacerbations of rheumatic disorders; collagen diseases, such as systemic lupus erythematosus and acute rheumatic carditis; severe dermatologic diseases; severe allergic conditions, such as seasonal or perennial allergic rhinitis, bronchial asthma, serum sickness, and drug hypersensitivity reactions; respiratory diseases, such as symptomatic sarcoidosis, Loffler's syndrome, berylliosis, fulminating or disseminated pulmonary tuberculosis, and aspiration pneumonitis; hematologic disorders, such as idiopathic thrombocytopenic purpura and secondary thrombocytopenia in adults, autoimmune hemolytic anemia, aplastic crisis, and congenital hypoplastic anemia; tuberculous meningitis and trichinosis with neurologic or myocardial involvement
To manage leukemias and lymphomas in adults and acute leukemia in children; to induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome without uremia or nephrotic syndrome caused by systemic lupus erythematosus
To provide palliative therapy during acute exacerbations of gastrointestinal diseases, such as ulcerative colitis and regional enteritis
Elixir, Oral Solution,Tablets, Intravenous or Intramuscular Injection
Adults. Highly individualized dosage based on severity of disorder. Usual:: 0.75 to 9 mg/ day as a single dose or in divided doses.
Elixir, Oral Solution,Tablets
Children. Highly individualized based on severity of disorder. Usual:: 83.3 to 333.3 meg/ kg daily in divided doses t.i.d. or q.i.d.
I.M. Injection
Children. Highly individualized based on severity of disorder. Usual:: 21 .lb to 166.65 meg/kg every 12 to 24 hr.
To manage adrenocortical insufficiency
Elixir, Oral Solution,Tablets, Intravenous or Intramuscular Injection
Adults. 0.5 to 9 mg daily as a single dose or in divided doses.
Elixir, Oral Solution,Tablets
Children. 23.3 meg/kg daily in divided doses t.i.d.
I.M. Injection
Children. 23.3 meg/kg daily in divided doses t.i.d. given every third day; alternatively, 7.76 to 11.65 meg/kg daily.
To test for Cushing's syndrome
Elixir, Oral Solution,Tablets
Adults. 0.5 mg every 6 hr for 48 hr followed by collection of 24-hr urine specimen to determine 17-hydroxycorticosteroid level. Or, 1 mg at 11 p.m. followed by plasma cortisol test performed at 8 a.m. the next day.
To distinguish Cushing's syndrome related to pituitary corticotropin excess from Cushing's syndrome from other causes
Elixir, Oral Solution,Tablets
Adults. 2 mg every 6 hr for 48 hr followed by collection of 24-hr urine specimen to determine 17-hydroxycorticosteroid level.
To decrease cerebral edema
Elixir, Oral Solution,Tablets
Adults. 2 mg every 8 to 12 hr as maintenance after parenteral form has controlled initial symptoms.
Intravenous or Intramuscular Injection
Adults. 10 mg intravenous followed by 4 mg intramuscular every 6 hr. Decreased after 2 to 4 days, if needed, gradually tapering off over 5 to 7 days unless inoperable or recurring brain tumor is present. If such a tumor is present, dosage gradually decreased after 2 to 4 days to maintenance dosage of 2 mg intramuscular every 8 to 12 hr and switched to P.O. regimen as soon as possible.
To treat unresponsive shock
I.V. Infusion and Injection
Adults. 20 mg as a single dose followed by 3 mg/kg over 24 hr as a continuous infusion; 40 mg as a single dose followed by 40 mg every 2 to 6 hr, as needed; or 1 mg/kg as a single dose. All regimens used no more than 3 days.
To decrease localized inflammation
Intra-Articular Injection Adults. 2 to 4 mg for large joint; 0.8 to 1 mg for small joint; 2 to 3 mg for bursae; 0.4 to 1 mg for tendon sheaths.
Soft-Tissue Injection
Adults. 2 to 6 mg; 1 to 2 mg for ganglia.
Intralesional Injection
Adults. 0.8 to 1.6 mg/injection site.
To decrease inflammation in allergic conditions or nasal polyps (except in sinuses)
Nasal Aerosol
Adults and children age 12 and over. 2 sprays (0.2 mg) in each nostril b.i.d. or t.i.d. Maximum: 12 sprays (1.2 mg) daily.
Children ages 6 to 12.
1 or 2 sprays (0.1 to 0.2 mg) in each nostril b.i.d.
Maximum:8 sprays (0.8 mg) daily.
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Contraindications of Drug
Read contraindications if you want cheap Decadron (Dexamethasone) online.
Administration of live-virus vaccine to patient or family member, hypersensitivity to dexamethasone or its components (including sulfites), idiopathic thrombocytopenic purpura (I.M. administration), systemic fungal infections
Generic Drug Interactions
Drugs
aminoglutethimide, antacids, barbiturates, carbamazepine, hydantoins, mitotane, rifampin: Decreased dexamethasone effects
amphotericin B (parenteral), carbonic anhydrase inhibitors: Risk of hypokalemia anticholinesterases: Decreased anticholines-terase effectiveness in myasthenia gravis
aspirin, NSAIDs: Increased risk of adverse gastrointestinal effects
cholestyramine: Increased dexamethasone clearance
cyclosporine: Increased activity of both drugs, possibly resulting in seizures
digoxin: Increased risk of digitalis toxicity related to hypokalemia
ephedrine: Decreased half-life and increased clearance of dexamethasone
erythromycin, indinavir: Increased clearance and decreased levels of these drugs
estrogens, ketoconazole, macrolide antibiotics: Decreased dexamethasone clearance
isoniazid: Decreased blood isoniazid level
neuromuscuhr blockers: Possibly potentiated or counteracted neuromuscular blockade
oral anticoagulants: Altered coagulation times, requiring reduced anticoagulant dosage
oral contraceptives: Increased half-life and concentration of dexamethasone phenytoin: Increased risk of seizures
potassium-wasting diuretics: Increased potassium loss and risk of hypokalemia
salicylates: Decreased blood level and effectiveness of salicylates
somatrem: Possibly inhibition of soma-trem's growth-promoting effect
thalidomide: Increased risk of toxic epidermal necrolysis
theophyllines: Altered effects of either drug
toxoids, vaccines: Decreased antibody response
Activities
alcohol use: Increased risk of gastrointestinal bleeding
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Drugs Adverse Reactions
Central Nervous System: Depression, emotional lability, euphoria, fever, headache, increased ICP with papilledema, insomnia, light-headedness, malaise, neuritis, neuropathy, paresthesia, psychosis, seizures, syncope, tiredness, vertigo, weakness
Cardiovascular: Arrhythmias, bradycardia, edema, fat embolism, heart failure, hypercholesterolemia, hyperlipidemia, hypertension, myocardial rupture, tachycardia, thromboembolism, thrombophlebitis, vasculitis
Eyes, Ears, Nose, And Throat: Cataracts, glaucoma, vision changes (all forms); epistaxis, loss of smell and taste, nasal burning and dryness, oral candidiasis, perforated nasal septum, pharyngitis, rebound nasal congestion, rhinorrhea, sneezing (nasal aerosol)
Endocrine: Cushingoid symptoms, decreased iodine uptake, growth suppression in children, hyperglycemia, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness
Gastrointestinal: Abdominal distention, bloody stools, elevated liver function test results, heartburn, hepatomegaly, increased appetite, indigestion, intestinal perforation, melena, nausea, pancreatitis, peptic ulcer with possible perforation, ulcerative esophagitis, vomiting
Genitourinary: Glycosuria, increased or decreased number and motility of spermatozoa, perineal irritation, urinary frequency
Hematologic: Leukocytosis, leukopenia
Musculoskeletal: Aseptic necrosis of femoral and humeral heads; muscle atrophy, spasms, or weakness; myalgia; osteoporosis; pathologic fracture of long bones; tendon rupture (intra-articular injection); vertebral compression fracture
Respiratory: Bronchospasm
Skin: Acne, allergic dermatitis, diaphoresis, ecchymosis, erythema, hirsutism, necrotizing vasculitis, petechiae, subcutaneous fat atrophy, striae, thin and fragile skin, urticaria
Other: Aggravated or masked signs of infection, anaphylaxis, angioedema, hypernatremia, hypocalcemia, hypokalemia, hypokalemic alkalosis, impaired wound healing, metabolic acidosis, sodium and fluid retention, suppressed skin test reaction, weight gain
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Nursing Considerations for Generic Drugs
• Use dexamethasone cautiously in patients with congestive heart failure, hypertension, or renal insufficiency because drug can cause sodium retention, which may lead to edema and hypokalemia.
• Also use cautiously in patients who have had intestinal sugery and in those with peptic ulcer, diverticulitis, or ulcerative colitis because of the risk of perforation.
• Give once-daily dose of dexamethasone in the morning to coincide with the body's natural cortisol secretion.
• Give oral drug with food to decrease gastrointestinal distress.
• Be aware that dosage forms with a concentration of 24 mg/ml are for intravenous use only.
• Shake intramuscular solution before injecting deep into large muscle mass.
WARNING Avoid subcutaneous injection; it may cause atrophy and sterile abscess.
• Inject undiluted intravenous dose directly into intravenous tubing of infusing compatible solution over 30 seconds or less, as prescribed.
WARNING Don't give acetate form by intravenous injection.
• Shake nasal aerosol container well, and hold it upright about 6" (15 cm) from area being treated. Keep spray out of patient's eyes, and advise her not to inhale it.
• Expect to taper drug rather than stopping it abruptly; prolonged use can cause adrenal suppression.
• Monitor fluid intake and output and daily weight, and watch for crackles, dyspnea, peripheral edema, and steady weight gain.
• Evaluate growth if patient is a child.
• Test stool for occult blood.
• Monitor results of hematology studies and blood glucose, serum electrolyte, cholesterol, and lipid levels. Dexamethasone may cause hyperglycemia, hypernatremia, hypocalcemia, hypokalemia, or leukopenia. It also may increase serum cholesterol and lipid levels, and it may decrease iodine uptake by the thyroid.
• Assess patient for evidence of osteoporosis, Cushing's syndrome, and other systemic effects during long-term use.
• Monitor neonate for signs of hypoadrenocorticism if mother received dexamethasone during pregnancy. Be aware that some preparations contain benzyl alcohol, which may cause a fatal toxic syndrome in neonates and immature infants.
• Watch for hypersensitivity reactions after giving acetate or sodium phosphate form; both may contain bisulfites or parabens, to which some people are allergic.
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Dexamethasone
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Dexamethasone and Neomycin Ear Spray; Dexamethasone Sodium Phosphate Injection; Dexamethasone Tablets;
The United States Pharmacopeia 31, 2008: Ciprofloxacin and Dexamethasone Otic Suspension; Dexamethasone Acetate Injectable Suspension; Dexamethasone Elixir; Dexamethasone Gel; Dexamethasone Ophthalmic Suspension; Dexamethasone Oral Solution; Dexamethasone Sodium Phosphate Cream; Dexamethasone Sodium Phosphate Inhalation Aerosol; Dexamethasone Sodium Phosphate Injection; Dexamethasone Sodium Phosphate Ophthalmic Ointment; Dexamethasone Sodium Phosphate Ophthalmic Solution; Dexamethasone Tablets; Dexamethasone Topical Aerosol; Neomycin and Polymyxin B Sulfates and Dexamethasone Ophthalmic Ointment; Neomycin and Polymyxin B Sulfates and Dexamethasone Ophthalmic Suspension; Neomycin Sulfate and Dexamethasone Sodium Phosphate Cream; Neomycin Sulfate and Dexamethasone Sodium Phosphate Ophthalmic Ointment; Neomycin Sulfate and Dexamethasone Sodium Phosphate Ophthalmic Solution; Tobramycin and Dexamethasone Ophthalmic Ointment; Tobramycin and Dexamethasone Ophthalmic Suspension.
Proprietary Preparations
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Sweden: Decadron cum neomycin;
Switzerland: Antikeloides Creme; Chronocor te; Corticetine; Cresophene; Dexalocal-F; Dexasalyl; Dexolan; Doxiproct Plus; Frakidex; Maxitrol; Nystalocal; Otospray; Pigmanorm; Polydexa; Sebo-Psor; Sofradex; Spersadex Comp; Spersadexoline; Tobradex;
Thailand: Archidex; Cadexcin- N; Decadron with Neomycin; Dexacin; Dexamytrex; Dexasil; Dexoph; Dexylin; Eyedex; Maxitrol; Neo-Optal; Neodex; Opsardex; Percutalgine; Sofradex; Spersadexoline; Tobradex; Trabit; Vesoph; The symbol denotes a preparation no longer actively marketed The symbol ? denotes a substance whose use may be restricted in certain sports (see p.vii)
UK or Britain: Dexa-Rhinaspray Duo; Maxitrol; Otomize; Sofradex; Tobradex;
Best Drugs World is a online pharmacy for cheap generic drugs. You can buy prescription drugs irrespective of your location at a very affordable prices.
US or USA: Ak-Neo-Dex; Ak-Trol; Ciprodex; Dexacidin; Dexacine; Dexasporin; Maxitrol; Neo-Dexameth; NeoDecadron; Neodexasone; Neopolydex; Ocu-Trol; Poly-Dex; Tobradex;
Buying generics, you will save a lot, as they are usually less expensive than brand name drugs. Take advantage of our low prices.
Venezuela: Baycuten N; Cipromet; Cyprodex; Decadron; Decaven; Deicol; Dexaneol; Dexapostafen; Gentidexa; Kanasone; Maxicort; Maxitrol; Otocort; Poentobral Plus; Poli-Otico; Quinocort; Tobracort; Tobradex; Tobragan D; Todex; Trazidex.
Do I need a prescription to buy generic Decadron (Dexamethasone) in your online drug store?
No. You can buy Decadron (Dexamethasone) without a prescription!
