Desyrel (Trazodone)
Class and Category of Drug
Before you buy Desyrel (Trazodone) online, read common information about the medication.
Chemical class: Triazolopyridine derivative
Therapeutic class: Antidepressant, anxiolytic
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Desyrel (Trazodone) online , you must read how it works.
To treat major depression, with or without generalized anxiety
Tablets
Adults. Initial: 150 mg daily in divided doses, increased by 50 mg daily every 3 to 4 days, p.r.n., as prescribed. Maximum: 400 mg daily for outpatients, 600 mg daily for inpatients.
Children ages 6 to 18. Initial: 1.5 to 2 mg/ kg daily in divided doses, increased every 3 to 4 days, p.r.n., as prescribed. Maximum: 6 mg/kg daily in divided doses.
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Contraindications of Drug
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Hypersensitivity to trazodone or its components, recovery from acute MI
Generic Drug Interactions
Drugs
anticonvulsants: Decreased seizure threshold
antihypertensives: Increased risk of excessive hypotension
anxiolytics, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, dimenhydrinate, diphenhydramine, doxylamine, general anesthetics, methdilazine, opioid analgesics, phenothiazines, sedative-hypnotics, skeletal muscle relaxants: Increased CNS depression, increased risk of respiratory depression and hypotension barbiturates: Decreased seizure threshold and barbiturate effects, increased drowsiness
buspirone, selective serotonin-reuptake inhibitors, tricyclic antidepressants: Possibly excessive serotonergic stimulation carbamazepine: Decreased trazodone level
clonidine: Interference with clonidine's antihypertensive effect
digoxin: Possibly increased blood digoxin level and risk of digitalis toxicity erythromycin, indinavir, itraconazole, ketoconazole, nefazodone, protease inhibitors, ritonavir: Possibly increased blood trazodone level with increased risk of adverse effects
MAO inhibitors: Increased serotonin effects warfarin: Decreased anticoagulation response
Activities
alcohol use: Increased CNS depression, risk of respiratory depression and hypotension
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Drugs Adverse Reactions
Central Nervous System: Dizziness, drowsiness, fatigue, headache, light-headedness, nervousness, suicidal ideation, syncope, tremor
Cardiovascular: Arrhythmias, hypotension, orthostatic hypotension, palpitations
Eyes, Ears, Nose, And Throat: Blurred vision, dry mouth
Gastrointestinal: Constipation, indigestion, nausea, vomiting
Genitourinary: Anorgasmia, ejaculation disorders, increased libido, priapism
Skin: Pruritus, rash
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Nursing Considerations for Generic Drugs
• Give trazodone shortly after the patient has a meal or light snack to reduce nausea.
• Give larger portion of daily dose at bedtime if drowsiness occurs.
• Because trazadone's mechanism of action is similar to that of selective serotonin reuptake inhibitors, expect high doses (6 to 8 mg/kg) to increase blood serotonin level and low doses (0.05 to 1 mg/kg) to decrease blood serotonin level.
• Expect most patients who respond to trazodone to do so by the end of the second week of therapy.
• Closely monitor depressed patients, including children and teens, for suicidal thoughts and tendencies. Notify prescriber if they occur, and take suicide precautions according to facility policy.
• Be aware that adverse CNS reactions usually improve after patient completes a few weeks of therapy.
WARNING Be aware that trazodone therapy may increase the risk of priapism.
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Trazodone
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
The United States Pharmacopeia 31, 2008: Trazodone Hydrochloride Tablets.
Proprietary Preparations
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