Diflucan (Fluconazole) - Anti-Fungus
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Top » Catalog » Anti-Fungus » Diflucan (Fluconazole)


Diflucan (Fluconazole)

$51.26


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Diflucan (Fluconazole)

Class and Category of Drug

Before you buy Diflucan (Fluconazole) online, read common information about the medication.

Chemical class: Triazole derivative

Therapeutic class: Antifungal

Pregnancy category: C

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Drug Indications and Dosages

Before purchase Diflucan (Fluconazole) online , you must read how it works.

To treat oral and esophageal candidiasis

Oral Suspension, Tablets, Intravenous Injection

Adults and adolescents. 200 mg on day 1 followed by 100 mg daily for at least 2 (oral) or 3 (esophageal) wk after symptoms resolve.

Children. 3 mg/kg daily for at least 2 (oral) or 3 (esophageal) wk and then for 2 wk after esophageal symptoms resolve.

To treat systemic candidiasis

Oral Suspension, Tablets, Intravenous Injection

Adults and adolescents. 400 mg on day 1, followed by 200 mg daily for at least 4 wk and then for additional 2 wk after symptoms resolve.

To treat cryptococcal meningitis

Oral Suspension, Tablets, Intravenous Injection

Adults and adolescents. 400 mg daily until patient responds to treatment, then 200 to 400 mg daily for 10 to 12 wk after CSF culture is negative. Maintenance: 200 mg daily to suppress relapse.

Children. 6 to 12 mg/kg daily for 10 to 12 wk after CSF culture is negative.

To prevent candidiasis after bone marrow transplantation

Oral Suspension, Tablets, Intravenous Injection

Adults and adolescents. 400 mg daily starting several days before procedure if severe neutropenia is expected and continued for 7 days after absolute neutrophil count exceeds 1,000/mm3.

To treat vaginal candidiasis

Capsules, Oral Suspension, Tablets

Adults. 150 mg as a single dose.

Dosage Adjustment Dosage reduced for patients with hepatic or renal impairment. Dosage reduced by 50% for patients with creatinine clearance of 11 to 50 ml/min/ 1.73 m2.

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Incompatibilities

Don't add fluconazole to intravenous bag that contains any other drug.

Contraindications of Drug

Read contraindications if you want cheap Diflucan (Fluconazole) online.

Hypersensitivity to fluconazole or its components

Generic Drug Interactions

Drugs

astemizole, terfenadine: Increased blood levels of these drugs

benzodiazepines (short-acting): Possibly increased benzodiazepine level and psychomotor effects

cimetidine: Decreased fluconazole level

cisapride: Possibly increased QT interval, leading to torsades de pointes

cyclosporine: Increased cyclosporine level

glipizide, glyburide, tolbutamide: Increased risk of hypoglycemia

hydrochlorothiazide: Increased fluconazole level from decreased excretion isoniazid, rifampin: Decreased fluconazole effects nonsedating antihistamines: Increased blood antihistamine level, increased risk of cardiotoxicity oral anticoagulants: Increased anticoagulant effects phenytoin: Increased phenytoin level rifabutin: Increased rifabutin level theophylline: Increased theophylline level zidovudine: Increased zidovudine level

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Drugs Adverse Reactions

Central Nervous System: Chills, dizziness, drowsiness, fever, headache, seizures

Cardiovascular: Prolonged QT interval, torsades de pointes

Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, hepatic failure, nausea, vomiting

Hematologic: Agranulocytosis, leukopenia, thrombocytopenia

Skin: Exfoliative dermatitis, photosensitivity, pruritus, rash

Other: Anaphylaxis, angioedema

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Nursing Considerations for Generic Drugs

• Use fluconazole cautiously in patients with potentially proarrhythmic conditions because drug may prolong the QT interval, which can lead to life-threatening torsades de pointes.

• Expect to obtain BUN and serum creatinine levels and culture and sensitivity and liver function test results before therapy starts.

• Refrigerate, but don't freeze, fluconazole oral suspension. Shake well before administering.

• Discard intravenous solution that's cloudy or contains precipitate. Don't infuse more than 200 mg/hr or add supplemental drugs to infusion.

• Monitor hepatic and renal function periodically during therapy, and notify pre-scriber if you detect signs of dysfunction.

• Assess for rash every 8 hours during therapy, and notify prescriber if rash occurs.

• If patient receives an oral anticoagulant, monitor coagulation test results and assess patient for bleeding.

• Monitor patient for symptoms of overdose, such as hallucinations and paranoia. If they occur, provide supportive treatment, gastric lavage, and, possibly, hemodialysis, which can reduce blood fluconazole level by half after about 3 hours.

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Diflucan (Fluconazole)

Preparations

International Brand Drug Names

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