Dipyridamole (Persantine)
Class and Category of Drug
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Chemical class: Pyrimidine
Therapeutic class: Coronary vasodilator, diagnostic aid, platelet aggregation inhibitor
Pregnancy category: B
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Drug Indications and Dosages
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To prevent thromboembolic complications of cardiac valve replacement
Tablets
Adults. 75 to 100 mg q.i.d. with coumarin or indanedione derivative anticoagulant.
To aid diagnosis during thallium perfu-sion imaging of myocardium
Intravenous Infusion
Adults. 0.57 mg/kg in 50 ml of D5W infused over 4 min. Maximum: 60 mg.
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Contraindications of Drug
Read contraindications if you want cheap Dipyridamole (Persantine) online.
Asthma (I.V.), hypersensitivity to dipyridamole or its components, hypotension, unstable angina pectoris
* After start of infusion, for increased velocity of coronary artery blood flow.
Generic Drug Interactions
Drugs
adenosine: Potentiated effects of adenosine
cefamandole, cefoperazone, cefotetan, plicamycin, valproic acid: Possibly hypoprothrombinemia and increased risk of bleeding
heparin, nonsteroidal anti-inflammatory drugs (NSAIDs), thrombolytics: Possibly increased risk of bleeding
theophylline: Reversal of coronary vasodilation caused by dipyridamole, possibly false-negative thallium imaging result
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Drugs Adverse Reactions
Central Nervous System: Dizziness, headache
Cardiovascular: Angina, arrhythmias, electrocardiogram changes (specifically, ST-segment and T-wave changes)
Gastrointestinal: Abdominal pain, diarrhea, nausea, vomiting
Respiratory: Dyspnea
Skin: Flushing, pruritus, rash
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Nursing Considerations for Generic Drugs
• Protect intravenous form of dipyridamole from direct light and freezing.
• Monitor blood pressure, pulse rate and rhythm, and breath sounds every 10 to 15 minutes during intravenous infusion.
• Keep parenteral aminophylline available to relieve adverse reactions to dipyridamole infusion.
• At therapeutic doses, expect adverse reactions to be minimal and transient. They typically resolve with long-term use.
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