Etodolac (Lodine)
Class and Category of Drug
Before you buy Etodolac (Lodine) online, read common information about the medication.
Chemical class: Pyranoindoleacetic acid derivative
Therapeutic class: Analgesic, anti-inflammatory
Pregnancy category: C
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Drug Indications and Dosages
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To manage osteoarthritis
Capsules,Tablets
Adults. Initial: 800 to 1,200 mg daily in divided doses. Maintenance: 600 to 1,200 mg daily in divided doses. Maximum: 1,200 mg daily for patients weighing 60 kg (132 lb) or more; 20 mg/kg daily for those less than 60 kg.
Extended-Release Tablets
Adults. 400 to 1,000 mg daily.
To relieve mild to moderate pain
Capsules,Tablets
Adults. Initial: 400 mg and then 200 to 400 mg every 6 to 8 hr. Maximum: 1,200 mg daily for patients weighing 60 kg or more; 20 mg/kg/day for patients weighing less than 60 kg.
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Contraindications of Drug
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Angioedema, asthma, bronchospasm, nasal polyps, rhinitis, or urticaria induced by aspirin, iodides, or NSAIDs; coronary artery bypass graft surgery; hypersensitivity to etodolac or its components
Generic Drug Interactions
Drugs
ACE inhibitors: Possibly decreased hypotensive effects of these drugs
acetaminophen (long-term use): Increased risk of adverse renal effects
antacids: Decreased blood etodolac level
antiplatelets, oral anticoagulants, thrombolytics: Prolonged prothrombin time (with warfarin), increased risk of bleeding
cidofovir: Possibly nephrotoxicity
corticosteroids: Increased risk of adverse gastrointestinal effects
cyclosporine: Increased nephrotoxic effects, increased blood cyclosporine level
digoxin: Increased blood digoxin level and risk of digitalis toxicity
insulin, oral antidiabetic drugs: Increased risk of hypoglycemia
lithium: Increased blood lithium level and, possibly, toxicity
loop diuretics: Possibly decreased effects of loop diuretics
methotrexate: Increased risk of methotrexate toxicity
phenylbutazone: Possibly altered etodolac clearance
salicylates: Decreased blood etodolac level, increased risk of adverse gastrointestinal effects
warfarin: Synergistic bleeding effects
Activities
alcohol use, smoking: Increased risk of adverse gastrointestinal effects
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Drugs Adverse Reactions
Central Nervous System: Asthenia, chills, depression, dizziness, drowsiness, fatigue, fever, insomnia, irritability, malaise, nervousness, seizures, somnolence, syncope, stroke
Cardiovascular: Edema, heart failure, hypertension, MI, palpitations, tachycardia, vasculitis
Eyes, Ears, Nose, And Throat: Blurred vision, deafness, loss of taste, photophobia, tinnitus
Endocrine: Hyperglycemia in diabetics
Gastrointestinal: Abdominal pain or distention, anorexia, constipation, diarrhea, diverticulitis, dyspepsia, dysphagia, elevated liver function test results, esophagitis, flatulence, gastritis, gastroenteritis, gastroesophageal reflux disease, gastrointestinal bleeding and ulceration, gastrointestinal perforation, hemorrhoids, hepatic failure, hepatitis, hiatal hernia, indigestion, melena, nausea, pancreatitis, peptic ulcer, perforation of stomach or intestines, stomatitis, vomiting
Genitourinary: Dysuria, elevated serum creatinine level, hematuria, renal failure or insufficiency, renal papillary necrosis, urinary frequency
Hematologic: Agranulocytosis, aplastic anemia, easy bruising, hemolytic anemia, leukope-nia, neutropenia, pancytopenia, thrombocytopenia
Musculoskeletal: Arthralgia, muscle pain
Respiratory: Asthma, bronchospasm, pulmonary infiltrate with eosinophilia, respiratory depression
Skin: Erythema multiforme, exfoliative dermatitis, flushing, leukocytoclastic vasculitis, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, vesiculobullous or other rash
Other: Anaphylaxis, angioedema, lymphadenopathy, sepsis
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Nursing Considerations for Generic Drugs
• Assess patient's hydration status and rehydrate, if needed and as ordered, before starting etodolac therapy.
• Use etodolac with extreme caution in patients with a history of ulcer disease or gastrointestinal bleeding because NSAIDs increase the risk of gastrointestinal bleeding and ulceration. Expect to use etodolac for the shortest time possible in these patients. Also use with extreme caution in patients with advanced renal disease because etodolac is eliminated mainly by the kidneys.
• Be aware that serious gastrointestinal tract ulceration, bleeding, and perforation may occur without warning symptoms. Elderly patents are at greater risk. To minimize risk, give drug with food. If gastrointestinal distress occurs, withhold drug and notify prescriber immediately.
• Use etodolac cautiously in patients with hypertension, and monitor blood pressure closely throughout therapy. Drug may cause hypertension or worsen it.
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Etodolac
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Etodolac Capsules; Etodolac Tablets;
The United States Pharmacopeia 31, 2008: Etodolac Capsules; Etodolac Extended-Release Tablets; Etodolac Tablets.
Proprietary Preparations
Austria: Lodine;
Brazil: Flancox;
Canada: Ultradol;
Denmark: Todolac;
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