Feldene (Piroxicam)
Class and Category of Drug
Before you buy Feldene (Piroxicam) online, read common information about the medication.
Chemical class: Oxicam derivative
Therapeutic class: Anti-inflammatory, anti-rheumatic
Pregnancy category: Not rated
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Drug Indications and Dosages
Before purchase Feldene (Piroxicam) online , you must read how it works.
To treat acute and chronic osteoarthritis and rheumatoid arthritis
Capsules
Adults. Initial: 20 mg once daily or 10 mg b.i.d.
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Contraindications of Drug
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Angioedema, asthma, bronchospasm, nasal polyps, rhinitis, or urticaria induced by aspirin, iodides, or other NSAIDs; hyper-sensitivity to piroxicam or its components
Generic Drug Interactions
Drugs
acetaminophen: Possibly increased adverse renal effects with long-term use of both drugs
antihypertensives: Possibly decreased or reversed effects of antihypertensives
aspirin, other NSAIDs: Increased risk of bleeding and adverse gastrointestinal effects, possibly increased blood piroxicam level
cefamandole, cefoperazone, cefotetan: Increased risk of hypoprothrombinemia and bleeding
colchicine: Increased risk of gastrointestinal bleeding, hemorrhage, and ulcers
corticosteroids, potassium supplements: Increased risk of adverse gastrointestinal effects
cyclosporine: Increased risk of nephrotoxicity from both drugs, increased blood cyclosporine level
diuretics: Decreased antihypertensive, diuretic, and natriuretic effects of diuretics
gold compounds, nephrotoxic drugs: Increased risk of adverse renal effects
heparin, oral anticoagulants, thrombolytics: Increased anticoagulant effects, increased risk of hemorrhage
insulin, oral antidiabetic drugs: Possibly increased hypoglycemic effect of these drugs
lithium: Possibly increased blood lithium level and toxicity
methotrexate: Decreased methotrexate clearance and increased risk of methotrexate toxicity
platelet aggregation inhibitors: Increased risk of bleeding and gastrointestinal ulceration or hemorrhage plicamycin, valproic acid: Increased risk of hypoprothrombinemia and gastrointestinal bleeding, hemorrhage, and ulceration probenecid: Possibly increased blood level, effectiveness, and risk of toxicity of piroxicam
Activities
alcohol use: Increased risk of adverse gastrointestinal effects
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Drugs Adverse Reactions
Central Nervous System: Anxiety, aseptic meningitis, asthenia, cerebral hemorrhage, confusion, depression, dizziness, dream disturbances, drowsiness, fever, headache, insomnia, ischemic stroke, malaise, nervousness, paresthesia, somnolence, syncope, transient ischemic attack, tremor, vertigo
Cardiovascular: Deep vein thrombosis, edema, heart failure, hypertension, MI, peripheral edema, tachycardia
Eyes, Ears, Nose, And Throat: Blurred vision, dry mouth, epistaxis, glossitis, stomatitis, tinnitus
Endocrine: Hypoglycemia
Gastrointestinal: Abdominal pain; anorexia; constipation; diarrhea; elevated liver function test results; esophagitis; flatulence; gastritis; gastrointestinal bleeding, perforation, or ulceration; heartburn; hematemesis; hepatitis; indigestion; jaundice; liver failure; melena; nausea; vomiting
Genitourinary: Acute renal failure, cystitis, dysuria, elevated serum creatinine level, hematuria, interstitial nephritis, nephrotic syndrome, oliguria, polyuria, proteinuria, renal failure or insufficiency
Hematologic: Agranulocytosis, anemia, aplastic anemia, coagulation abnormalities, eosinophilia, leukopenia, pancytopenia, thrombocytopenia
Respiratory: Asthma, dyspnea
Skin: Alopecia, diaphoresis, ecchymosis, erythema, erythema multiforme, exfoliative dermatitis, photosensitivity, pruritus, purpura, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria
Other: Anaphylaxis, angioedema, flulike symptoms, hyperkalemia, infection, sepsis, weight loss or gain
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Nursing Considerations for Generic Drugs
Administer piroxicam with food to decrease gastrointestinal upset.
Use piroxicam with extreme caution in patients with a history of ulcer disease or gastrointestinal bleeding because NSAIDs such as piroxicam increase risk of gastrointestinal bleeding and ulceration. Expect to use piroxicam for the shortest time possible in these patients.
Be aware that serious gastrointestinal tract ulceration, bleeding, and perforation may occur without warning symptoms. Elderly patients are at greater risk. To minimize risk, give drug with food. If gastrointestinal distress occurs, withhold drug and notify prescriber at once.
Use piroxicam cautiously in patients with hypertension, and monitor blood pressure closely throughout therapy. Drug may cause hypertension or worsen it.
WARNING Monitor patient closely for thrombotic events, including MI and stroke, because NSAIDs increase the risk.
WARNING If patient has bone marrow suppression or is receiving antineoplastic drug therapy, monitor laboratory results (including WBC count), and watch for evidence of infection because anti-inflammatory and antipyretic actions of piroxicam may mask signs and symptoms, such as fever and pain.
Especially if patient is elderly or taking drug long-term, watch for less common but serious adverse gastrointestinal reactions, including anorexia, constipation, diverticulitis, dysphagia, esophagitis, gastritis, gastroenteritis, gastroesophageal reflux disease, hemorrhoids, hiatal hernia, melena, stomatitis, and vomiting.
Monitor liver function test results because, rarely, elevated levels may progress to severe hepatic reactions, including fatal hepatitis, liver necrosis, and hepatic failure.
Monitor BUN and serum creatinine levels in patients with heart failure, impaired renal function, or hepatic dysfunction; those taking diuretics or ACE inhibitors; and elderly patients because drug may cause renal failure.
Monitor CBC for decreased hemoglobin level and hematocrit because drug may worsen anemia.
Assess patient's skin routinely for rash or other signs of hypersensitivity reaction
because piroxicam and other NSAIDs may cause serious skin reactions without warning, even in patients with no history of NSAID hypersensitivity. Stop drug at first sign of reaction, and notify prescriber.
WARNING Be aware that drug may cause premature closure of ductus arteriosus in growing fetus during third trimester of pregnancy. Be prepared to suggest referral for high-risk pregnancy.
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Piroxicam
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Piroxicam Capsules; Piroxicam Gel;
The United States Pharmacopeia 31, 2008: Piroxicam Capsules; Piroxicam Cream.
Proprietary Preparations
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