Flagyl ER (Metronidazole)
Class and Category of Drug
Before you buy Flagyl ER (Metronidazole) online, read common information about the medication.
Chemical class: Nitroimidazole derivative
Therapeutic class: Antibiotic, antiprotozoal
Pregnancy category: B
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Drug Indications and Dosages
Before purchase Flagyl ER (Metronidazole) online , you must read how it works.
To treat systemic anaerobic infections caused by Bacteroides fragilis, Clostridium difficile, Clostridium perfringens, Eubacterium, Fusobacterium, Peptococcus, Peptostreptococcus, and Veillonella species
Capsules,Tablets
Adults and adolescents. 7.5 mg/kg up to 1,000 mg every 6 hr for 7 days or longer. Maximum: 4,000 mg daily.
Children. 7.5 mg/kg every 6 hr or 10 mg/kg every 8 hr.
Intravenous Infusion
Adults and adolescents. Initial: 15 mg/kg and then 7.5 mg/kg up to 1,000 mg every 6 hr for 7 days or longer. Maximum: 4,000 mg daily.
Children. 7.5 mg/kg every 6 hr or 10 mg/kg every 8 hr.
To treat amebiasis (Entamoeba histolytica>
Capsules,Tablets
Adults. 500 to 750 mg t.i.d. for 5 to 10 days.
Children. 11.6 to 16.7 mg/kg t.i.d. for 10 days.
Capsules,Tablets
Adults. 2,000 mg as a single dose, 1,000 mg b.i.d. for 24 hr, or 250 mg t.i.d. for 7 days.
Children. 5 mg/kg t.i.d. for 7 days.
To prevent perioperative bowel infection
Intravenous Infusion
Adults and adolescents. 15 mg/kg 1 hr before surgery and then 7.5 mg/kg 6 and 12 hr after initial dose.
To treat acne in patients with rosacea
Topical Gel
Adults. Thin film applied to affected area b.i.d. for 9 wk.
To treat bacterial vaginosis
Vaginal Cream
Adults. 500 mg (1 applicatorful) once or twice daily for 10 to 20 days.
Vaginal Gel
Adults. 37.5 mg (1 applicatorful) once or twice daily for 5 days.
Vaginal Tablets
Adults. 500 mg at bedtime for 10 to 20 days.
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Incompatibilities
Don't administer intravenous metronidazole with aluminum needles or hubs or through same intravenous line as other drugs.
Contraindications of Drug
Read contraindications if you want cheap Flagyl ER (Metronidazole) online.
Breast-feeding, hypersensitivity to metronidazole or its components, trichomoniasis during first trimester of pregnancy
Generic Drug Interactions
Drugs
cimetidine: Possibly delayed elimination and increased blood level of metronidazole
disulfiram: Possibly combined toxicity, with confusion and psychotic reactions neurotoxic drugs: Increased risk of neurotoxicity
oral anticoagulants: Possibly increased anticoagulant effect
phenobarbital: Increased metabolism and decreased blood level and half-life of metronidazole
phenytoin: Decreased phenytoin clearance Activities alcohol use: Possibly disulfiram-like effects
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Drugs Adverse Reactions
Central Nervous System: Aseptic meningitis (parenteral form), ataxia, confusion, dizziness, encephalopathy, fever, headache, incoordination, insomnia, irritability, light-headedness, peripheral neuropathy, seizures (high doses), syncope, weakness, vertigo
Eyes, Ears, Nose, And Throat: Dry mouth, lacrimation (topical form), metallic taste, nasal congestion, optic neuropathy, pharyngitis
Gastrointestinal: Abdominal cramps or pain, anorexia, diarrhea, nausea, pancreatitis, vomiting
Genitourinary: Dark urine, Vaginal candidiasis (oral, parenteral, and topical forms); burning or irritation of sexual partner's penis, candidal cervicitis or vaginitis, dysuria, dryness of vagina or vulva, urinary frequency, vulvitis (Vaginal form), skin (topical form); erythema, flushing, pruritus, rash, Stevens Johnson syndrome, urticaria (oral and parenteral forms)
Hematologic: Leukopenia
Musculoskeletal: Back pain, dysarthria
Skin: Burning or stinging sensation, dry gel away from his eyes. If drug gets into his eyes, urge him to wash them immediately with large amounts of cool tap water and to call prescriber if eyes continue to hurt or burn.
Instruct patient with rosacea to notify prescriber if no improvement occurs after 3 weeks of topical use; full therapeutic effect may take 9 weeks. Teach patient how to fill, insert, and clean Vaginal cream or gel applicator after use. Instruct her to wash her hands before and after administration. To help Vaginal tablets dissolve, instruct patient to run tap water over unwrapped tablet for a few seconds before insertion. Inform patient with trichomoniasis that her male sexual partners should wear condoms during her treatment and that they may need treatment themselves to prevent reinfection.
Caution patient that Vaginal cream and tablets (not gel) may contain oils that damage latex condoms. Urge patient to follow up with prescriber to make sure infection is gone.
Other: Injection site edema, pain, or tenderness
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Nursing Considerations for Generic Drugs
• Give intravenous drug by slow infusion over
1 hour; don't give by direct intravenous injection.
• Discontinue primary intravenous infusion during metronidazole infusion.
WARNING If patient has adverse CNS reactions, such as seizures or peripheral neuropathy, tell prescriber and stop drug immediately.
• Monitor patient with severe liver disease because slowed metronidazole metabolism may cause drug to accumulate in body and increase the risk of adverse effects.
• If skin irritation occurs, apply topical metronidazole gel less frequently or discontinue it, as ordered.
• Monitor CBC and culture and sensitivity tests if therapy lasts longer than 10 days or if second course of treatment is needed.
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