Fluoxetine (Prozac)
Class and Category of Drug
Before you buy Fluoxetine (Prozac) online, read common information about the medication.
Chemical class: Phenylpropylamine derivative
Therapeutic class: Antibulimic, antidepressant, antiobsessive-compulsive
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Fluoxetine (Prozac) online , you must read how it works.
To treat depression
Capsules, Oral Solution,
Tablets (Prozac) Adults. Initial: 20 mg daily in the morning. Dosage increased every 4 to 8 wk as needed. Dosage greater than 20 mg daily given b.i.d. morning and noon. Maximum: 80 mg daily.
Children and adolescents. Initial: 10 mg daily. Increased after 1 wk to 20 mg daily.
Dosage Adjustment For lower-weight children, dosage increased to 20 mg daily only if improvement insufficient after several wk.
Delayed-Release Capsules (Prozac Weekly) Adults. 90 mg/wk, beginning 7 days after last 20-mg daily dose.
To treat obsessive-compulsive disorder
Capsules, Oral Solution,
Tablets (Prozac) Adults. Initial: 20 mg daily in the morning. Dosage increased every 4 to 8 wk as needed. Dosage greater than 20 mg daily given b.i.d. morning and noon. Maximum: 80 mg daily.
Children and adolescents. Initial: 10 mg daily. Dosage increased after 2 wk to 20 mg daily. Subsequent dosage increased, as needed, at intervals of at least several wk. Maintenance: 20 to 60 mg daily.
Dosage Adjustment For lower-weight children, dosage should be increased above 10 mg daily only if clinical improvement remains insufficient after several wk. Maintenance dosage for such patients should not exceed 30 mg daily.
To treat moderate to severe bulimia nervosa
Capsules, Oral Solution,Tablets (Prozac)
Adults. 60 mg daily in the morning. Some patients may be prescribed a lower dose, which is titrated to 60 mg daily as tolerated.
To treat panic disorder with or without agoraphobia
Capsules, Oral Solution,Tablets (Prozac)
Adults. Initial: 10 mg daily. Dosage increased in 1 wk to 20 mg daily, as needed. Maximum: 60 mg daily.
To treat premenstrual dysmorphic disorder
Capsules (Sarafem)
Adults. 20 mg daily. Dosage increased as needed. Maximum: 80 mg daily.
Dosage Adjustment Dose or frequency reduced for patients with hepatic impairment or concurrent illness, those who take multiple medications, and for elderly patients.
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Contraindications of Drug
Hypersensitivity to selective serotonin reuptake inhibitors or their components, use within 14 days of MAO inhibitor therapy
Generic Drug Interactions
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Drugs
alprazolam, diazepam: Possibly prolonged half-life of these drugs aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin: Increased anticoagulant activity and risk of bleeding astemizole: Increased risk of serious arrhythmias
buspirone: Decreased buspirone effects clozapine, fluphenazine, haloperidol, maprotiline, trazodone: Increased risk of adverse effects
CYP2D6-metabolized drugs, such as antiarrhythmics (especially flecainide, propafenone), selected antidepressants (tricyclics), antipyschotics (phenothiazines and most atypicals), thioridazine, and vinblastine: Increased plasma levels of these drugs and increased risk of serious adverse reactions
linezolid, lithium, serotonergics (such as amphetamines and other psychostimulants, antidepressants, and dopamine agonists), St. John's wort, tramadol, triptans: Increased risk of serotonin syndrome
MAO inhibitors: Possibly severe and life-threatening adverse effects
phenytoin: Increased blood phenytoin level and risk of toxicity
pimozide: Possibly bradycardia
sumatriptan: Increased risk of weakness, hyperreflexia, and difficulty with coordination
* Capsules, oral solution, and tablets. f For depression and bulimia; 5 wk for obsessive-compulsive disorder.
tryptophan: Increased risk of central and peripheral toxicity
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Drugs Adverse Reactions
Central Nervous System: Anxiety, chills, dream disturbances, drowsiness, fatigue, fever, headache, hypomania, insomnia, mania, nervousness, neuroleptic malignant syndrome, restlessness, seizures, serotonin syndrome, somnolence, suicidal ideation, tremor, vertigo, weakness, yawning
Cardiovascular: Hypotension, palpitations
Eyes, Ears, Nose, And Throat: Abnormal vision, dry mouth, pharyngitis, sinusitis
Endocrine: Galactorrhea, gynecomastia, hypoglycemia, syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Gastrointestinal: Anorexia, diarrhea, indigestion, nausea
Genitourinary: Decreased libido, ejaculation disorders, impotence
Hematologic: Altered platelet function, unusual bleeding
Musculoskeletal: Arthralgia, myalgia
Respiratory: Dyspnea
Skin: Diaphoresis, pruritus, rash, urticaria
Other: Flulike symptoms, hyponatremia, weight loss
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Nursing Considerations for Generic Drugs
• Use fluoxetine cautiously in patients with a history of seizures.
WARNING Avoid giving fluoxetine within 14 days of an MAO inhibitor or starting MAO inhibitor therapy within 5 weeks of discontinuing fluoxetine.
• In patients taking fluoxetine for depression (especially children, adolescents, and young adults), watch closely for suicidal tendencies, particularly when therapy starts and dosage changes, because depression may worsen temporarily during those times.
• Monitor patient closely for evidence of gastrointestinal bleeding, especially if patient takes another drug known to increase the risk, such as aspirin, an NSAID, or warfarin.
• Monitor patient — especially an elderly patient — for hypoosmolarity of serum and urine and for hyponatremia (headache, difficulty concentrating, memory impairment, weakness, unsteadiness), which may indicate fluoxetine-induced SIADH.
• To discontinue, expect to taper drug, as ordered, to minimnize adverse reactions.
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Fluoxetine
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Fluoxetine Capsules; Fluoxetine Oral Solution;
The United States Pharmacopeia 31, 2008: Fluoxetine Capsules; Fluoxetine Delayed-Release Capsules; Fluoxetine Oral Solution; Fluoxetine Tablets.
Proprietary Preparations
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