Fosamax (Alendronate)
Class and Category of Drug
Before you buy Fosamax (Alendronate) online, read common information about the medication.
Chemical class: Aminobisphosphonate
Therapeutic class: Bone resorption inhibitor
Pregnancy category: C
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Drug Indications and Dosages
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To prevent postmenopausal osteoporosis
Tablets
Adults. 5 mg daily or 35 mg once/wk in the morning with a full glass of water at least 30 min before first food, drink, or drug.
To treat postmenopausal osteoporosis
Tablets
Adults. 10 mg daily or 70 mg once/wk in the morning with a full glass of water at least 30 min before first food, drink, or drug.
To treat Paget's disease of the bone in patients whose alkaline phosphatase level is twice the upper limit of normal or higher and who are symptomatic and at risk for further complications
Tablets
Adults. 40 mg daily with a full glass of water for 6 mo.
Dosage Adjustment
Dosage increased to 10 mg daily for postmenopausal women not receiving estrogen.
To increase bone mass in men with osteoporosis
Tablets
Adults. 10 mg daily or 70 mg once/wk in the morning with a full glass of water at least 30 min before first food, drink, or drug.
To treat glucocorticoid-induced osteoporosis in men and women who receive a daily glucocorticoid dosage of 7.5 mg of greater of prednisone and who have low bone mineral density
Tablets
Adults. 5 mg daily in the morning with a full glass of water at least 30 min before first food, drink, or drug.
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Contraindications of Drug
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Esophageal abnormalities that delay esophageal emptying, such as stricture or achalasia; hypersensitivity to alendronate; hypocalcemia; inability to stand or sit upright for at least 30 minutes
Generic Drug Interactions
Drugs
antacids, calcium, iron, multivalent cations: Decreased absorption of alendronate
aspirin: Increased risk of gastrointestinal distress
Foods
any food: Delayed absorption and decreased serum level of alendronate
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Drugs Adverse Reactions
Central Nervous System: Asthenia, dizziness, headache, vertigo
Cardiovascular: Peripheral edema
Gastrointestinal: Abdominal distention and pain, constipation, diarrhea, dysphagia, esophageal perforation or ulceration, esophagitis, flatulence, gastritis, gastroesophageal reflux disease, heartburn, indigestion, melena, nausea, vomiting
* After single 5-mg dose for osteoporosis; 6 mo after single 5-mg dose for Paget's of days!
Musculoskeletal: Arthralgia, bone pain, focal osteomala-cia, joint swelling, muscle spasms, myalgia
Skin: Photosensitivity, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis
Other: Hypocalcemia
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Nursing Considerations for Generic Drugs
• Monitor patient's serum calcium level before, during, and after treatment. Expect hypocalcemia to be treated before alendronate therapy. If hypocalcemia occurs during therapy, expect prescriber to order a calcium supplement.
• Ensure adequate dietary intake of calcium and vitamin D before, during, and after treatment.
WARNING Alendronate may irritate upper gastrointestinal mucosa, causing adverse reactions such as esophageal ulceration. To help minimize these reactions, have patient take drug with a full glass of water and remain upright for at least 30 minutes.
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Alendronate
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
The United States Pharmacopeia 31, 2008: Alendronate Sodium Tablets.
Proprietary Preparations
Argentina: Actimax; Alenato; Arendal; Berlex; Brek; Dronat; Elandur; Filxine; Findeclin; Findeclin Combi; Fosamax; Lafedam; Lendronal; Marvil; Maxtral; Oseotenk; Osteobon; Osteofene; Osteonate; Phostarac; Regenesis; Silidral; Tilios;
Australia: Adronat; Alendro; Fosamax; Ossmax;
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Belgium: Fosamax;
Brazil: Alendil; Bonalen; Cleveron; Endronax; Fosamax; Minusorb; Ossomax; Ostenan; Osteofar; Osteoform; Osteoral; Osteotrat; Recalfe; Terost;
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The pharmaceutical companies our pharmacies buy from follow strict WHO standards for GMP.
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Czech Republic: Alendrogen; Alenwin; Bonalen; Fosamax; Fosteofos; Gendron; Lindron; Ralenost; Siranin;
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India: Bifosa; Osteofos;
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