Furosemide (Lasix)
Class and Category of Drug
Before you buy Furosemide (Lasix) online, read common information about the medication.
Chemical class: Sulfonamide
Therapeutic class: Antihypertensive, diuretic
Pregnancy category: C
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Drug Indications and Dosages
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To reduce edema caused by cirrhosis, heart failure, and renal disease, including nephrotic syndrome
Oral Solution
Tablets Adults. 20 to 80 mg as a single dose, increased by 20 to 40 mg every 6 to 8 hr until desired response occurs. Maximum: 600 mg daily.
Children. 2 mg/kg as a single dose, increased by 1 to 2 mg/kg every 6 to 8 hr until desired response occurs. Maximum: 6 mg/kg/dose.
Intravenous Infusion, intravenous or Intramuscular Injection
Adults. 20 to 40 mg as a single dose, increased by 20 mg every 2 hr until desired response occurs.
Children. 1 mg/kg as a single dose, increased by 1 mg/kg every 2 hr until desired response occurs. Maximum: 6 mg/kg/dose.
Dosage Adjustment
Initial single dose limited to 20 mg for elderly patients.
To manage mild to moderate hypertension, as adjunct to treat acute pulmonary edema and hypertensive crisis
Oral Solution,Tablets
Adults. Initial: 40 mg b.i.d., adjusted until desired response occurs. Maximum: 600 mg daily.
Intravenous Infusion or Injection
Adults with normal renal function. 40 to 80 mg as a single dose over several minutes
Adults with acute renal failure or pulmonary edema. 100 to 200 mg as a single dose over several minutes.
Dosage Adjustment For patients with acute pulmonary edema without hypertensive crisis, dosage reduced to 40 mg followed by 80 mg 1 hr later if therapeutic response doesn't occur.
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Incompatibilities
Don't mix furosemide (a milky, buffered alkaline solution) with highly acidic solutions.
Contraindications of Drug
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Anuria unresponsive to furosemide; hypersensitivity to furosemide, sulfonamides, or their components
Generic Drug Interactions
Drugs
ACE inhibitors: Possibly first-dose hypotension
aminoglycosides, cisplatin: Increased risk of ototoxicity
amiodarone: Increased risk of arrhythmias from hypokalemia
chloral hydrate: Possibly diaphoresis, hot flashes, and hypertension
digoxin: Increased risk of digitalis toxicity related to hypokalemia
insulin, oral antidiahetic drugs: Increased blood glucose level
lithium: Increased risk of lithium toxicity NSAIDs: Possibly decreased diuresis phenytoin, probenecid: Possibly decreased therapeutic effects of furosemide propranolol: Possibly increased blood propranolol level
thiazide diuretics: Possibly profound diuresis and electrolyte imbalances
Activities
alcohol use: Possibly increased hypotensive and diuretic effects of furosemide
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Drugs Adverse Reactions
Central Nervous System: Dizziness, fever, headache, paresthesia, restlessness, vertigo, weakness
Cardiovascular: Orthostatic hypotension, shock, thromboembolism, thrombophlebitis
Eyes, Ears, Nose, And Throat: Blurred vision, oral irritation, ototoxicity, stomatitis, tinnitus, transient hearing loss (rapid intravenous injection), yellow vision
Endocrine: Hyperglycemia
Gastrointestinal: Abdominal cramps, anorexia, constipation, diarrhea, gastric irritation, hepatocel-lular insufficiency, indigestion, jaundice, nausea, pancreatitis, vomiting
Genitourinary: Bladder spasms, glycosuria
Hematologic: Agranulocytosis (rare), anemia, aplastic anemia (rare), azotemia, hemolytic anemia, leukopenia, thrombocytopenia
Musculoskeletal: Muscle spasms
Skin: Bullous pemphigoid, erythema multiforme, exfoliative dermatitis, photosensitivity, pruritus, purpura, rash, urticaria
Other: Allergic reaction (interstitial nephritis, necrotizing vasculitis, systemic vasculitis), dehydration, hyperuricemia, hypochloremia, hypokalemia, hyponatremia, hypovolemia
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Nursing Considerations for Generic Drugs
WARNING Use furosemide cautiously in patients with advanced hepatic cirrhosis, especially those who also have a history of electrolyte imbalance or hepatic encephalopathy; drug may lead to lethal hepatic coma.
• Obtain patient's weight before and periodically during furosemide therapy to monitor fluid loss.
• For once-a-day dosing, give drug in the morning so patient's sleep won't be interrupted by increased need to urinate.
• Prepare drug for infusion with normal saline solution, lactated Ringer's solution, or D5W.
• Administer drug slowly intravenous over 1 to 2 minutes to prevent ototoxicity.
• Expect patient to have periodic hearing tests during prolonged or high-dose intravenous therapy.
• Monitor blood pressure and hepatic and renal function as well as BUN, blood glucose, and serum creatinine, electrolyte, and uric acid levels, as appropriate.
• Be aware that elderly patients are more susceptible to hypotensive and electrolyte-altering effects and thus are at greater risk for shock and thromboembolism.
• If patient is at high risk for hypokalemia, give potassium supplements along with furosemide, as prescribed.
• Expect to discontinue furosemide at maximum dosage if oliguria persists for more than 24 hours.
• Be aware that furosemide may worsen left ventricular hypertrophy and adversely affect glucose tolerance and lipid metabolism.
• Notify prescriber if patient experiences hearing loss, vertigo, or ringing, buzzing, or sense of fullness in her ears. Drug may need to be discontinued.
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Furosemide
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Co-amilofruse Tablets; Furosemide Injection; Furosemide Tablets;
The United States Pharmacopeia 31, 2008: Furosemide Injection; Furosemide Oral Solution; Furosemide Tablets.
Proprietary Preparations
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