Glucophage (Metformin)
Class and Category of Drug
Before you buy Glucophage (Metformin) online, read common information about the medication.
Chemical class: Dimethylbiguanide
Therapeutic class: Antidiabetic
Pregnancy category: B
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Drug Indications and Dosages
Before purchase Glucophage (Metformin) online , you must read how it works.
To reduce blood glucose level in type 2 diabetes mellitus
Oral Solution,Tablets
Adults and children age 10 and over. Initial: 500 mg b.i.d. or 850 mg daily, increased as prescribed by 500 mg/wk or by 850 mg every 2 wk until desired response occurs. Usual:: 500 to 850 mg b.i.d. or t.i.d. Maximum: 2,550 mg daily (adults and adolescents age 17 and over); 2,000 mg daily (children ages 10 to 16).
Dosage Adjustment If patient uses insulin, initial dosage reduced to 500 mg daily and then increased as prescribed by 500 mg weekly until blood glucose level is controlled.
E.R. Tablets (Glucophage XR, Glumetza)
Adults and adolescents age 18 and over. Initial: 500 mg daily (Glucophage XR) or 1,000 mg daily (Glumetza) with evening meal. Increased as prescribed by 500 mg/wk. Maximum: 2,000 mg daily.
Dosage Adjustment
If control isn't achieved with maximum once-daily E.R. dosage, regimen may be changed to 1,000 mg b.i.d. If control isn't achieved after 4 wk of maximum dosage, an oral sulfonylurea may be prescribed.
E.R. Tablets (Fortamet)
Adults and adolescents age 17 and over. Initial: 500 to 1,000 mg once daily in evening. Increased in increments of 500 mg weekly, as needed. Maximum: 2,500 mg daily. If control isn't achieved after 4 wk at maximum dosage, an oral sulfonylurea may be prescribed.
As adjunct to insulin therapy in type 2 diabetes mellitus
Oral Solution,Tablets, E.R.
Tablets Adults. Initial: 500 mg (Glucophage, Glucophage XR, Fortamet) or 1,000 mg (Glumetza) daily in addition to current dose of insulin. Increased by 500 mg/wk, as needed. Maximum: 2,000 mg for Glucophage XR and Glumetza; 2,500 mg for Glucophage and Fortamet.
Dosage Adjustment If fasting blood glucose level drops below 120 mg/dl, insulin dosage decreased by 10% to 25%. Subsequent insulin dosage decrease may be needed based upon patient's continued response.
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Contraindications of Drug
Read contraindications if you want cheap Glucophage (Metformin) online.
Hypersensitivity to metformin or its components, impaired renal function, metabolic acidosis, use of iodinated contrast media within preceding 48 hours
Generic Drug Interactions
Drugs
calcium channel blockers, corticosteroids, estrogens, isoniazid, nicotinic acid, oral contraceptives, phenothiazines, phenytoin, sympathomimetics, thiazide and other diuretics, thyroid drugs: Possibly hyperglycemia
cationic drugs (such as amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin), nifedipine: Increased blood metformin level
clofibrate, MAO inhibitors, probenecid, propranolol, rifabutin, rifampin, salicylates, sulfonamides, sulfonylureas: Increased risk of hypoglycemia
Foods
all foods: Possibly delayed metformin absorption
Activities
alcohol use: Increased risk of hypoglycemia and lactate formation
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Drugs Adverse Reactions
Central Nervous System: Headache
Eyes, Ears, Nose, And Throat: Metallic taste
Endocrine: Hypoglycemia
Gastrointestinal: Abdominal distention, anorexia, constipation, diarrhea, flatulence, indigestion, nausea, vomiting
Hematologic: Aplastic anemia, megaloblastic anemia, thrombocytopenia
Skin: Photosensitivity, rash
Other: Lactic acidosis, weight loss
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Nursing Considerations for Generic Drugs
• Give metformin tablets with food, which decreases and slightly delays absorption, thus reducing risk of adverse gastrointestinal reactions. Give E.R. tablets with evening meal; don't break or crush them.
• Expect prescriber to alter dosage if patient has a condition that decreases or delays gastric emptying, such as diarrhea, gastroparesis, gastrointestinal obstruction, ileus, or vomiting.
• Expect to assess BUN and serum creatinine level before and during long-term therapy in those at increased risk for lactic acidosis.
• Monitor patient's hepatic function, as ordered, because impaired hepatic function may significantly reduce the liver's ability to clear lactate, predisposing the patient to lactic acidosis.
• Monitor patient's blood glucose level to evaluate drug effectiveness. Assess for hyperglycemia and the need for insulin during times of increased stress, such as infection and surgery.
•Withhold drug, as ordered, if patient becomes dehydrated or develops hypoxemia or sepsis because these conditions increase the risk of lactic acidosis.
• Iodinated contrast media used in radiographic studies increases risk of renal failure and lactic acidosis during metformin therapy. Expect to withhold drug for 48 hours before and after testing.
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Metformin
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Metformin Tablets;
The United States Pharmacopeia 31, 2008: Glipizide and Metformin Hydrochloride Tablets; Glyburide and Metformin Hydrochloride Tablets; Metformin Hydrochloride Extended-Release Tablets; Metformin Hydrochloride Tablets.
Proprietary Preparations
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Multi-ingredient
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