Inderal LA (Propranolol)
Class and Category of Drug
Before you buy Inderal LA (Propranolol) online, read common information about the medication.
Chemical class: Beta-adrenergic blocker
Therapeutic class: Antianginal, antiarrhythmic, antihypertensive, anti-MI, anti-migraine, antitremor, hypertrophic cardiomyopathy and pheochromocytoma therapy adjunct
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Inderal LA (Propranolol) online , you must read how it works.
To manage hypertension
E.R. Tablets
Adults. Initial: 80 mg daily, increased gradually up to 160 mg daily Maximum: 640 mg daily.
Inform patient that she may take propoxyphene with food if she has gastrointestinal distress. Caution patient not to take more than prescribed amount because drug may be addictive or cause accidental overdose. Inform patient that drug may cause blurred vision, drowsiness, dizziness, and impaired judgment and coordination. Urge her to avoid hazardous activities until drug's CNS effects are known. Instruct patient to avoid alcohol and other sedatives while taking drug. Advise smokers to inform prescriber if they try to stop smoking during propoxyphene therapy because increased dosage may be needed for effective analgesia. Urge patient to notify prescriber immediately if pain isn't relieved or worsens.
Tablets (Innopran XL) XL
Adults. Initial: 80 mg once daily at bedtime, increased, as needed, to 120 mg once daily at bedtime.
Oral Solution,Tablets
Adults. Initial: 40 mg b.i.d., increased gradually to 120 to 240 mg daily, as needed. Maximum: 640 mg daily. Children. Initial: 0.5 to 1 mg/kg daily in divided doses b.i.d. to q.i.d., adjusted as needed. Maintenance: 2 to 4 mg/kg daily in divided doses b.i.d.
To treat chronic angina
E.R.Tablets
Adults. Initial: 80 mg daily, increased every 3 to 7 days, as prescribed. Maximum: 320 mg/day
Oral Solution,Tablets
Adults. 80 to 320 mg daily in divided doses b.i.d., t.i.d., or q.i.d.
To treat supraventricular arrhythmias and ventricular tachycardia
Oral Solution,Tablets
Adults. 10 to 30 mg t.i.d. or q.i.d., adjusted as needed.
Intravenous Injection
Adults. 1 to 3 mg at a rate not to exceed 1 mg/min; repeated after 2 min and again after 4 hr, if needed.
Children. 0.01 to 0.1 mg/kg at a rate not to exceed 1 mg/min; repeated every 6 to 8 hr, as needed. Maximum: 1 mg/dose.
To control tremor
Oral Solution,Tablets
Adults. Initial: 40 mg b.i.d., adjusted as needed and prescribed. Maximum: 320 mg daily.
To prevent vascular migraine headaches
E.R. Tablets
Adults. Initial: 80 mg daily, increased gradually, as needed. Maximum: 240 mg daily.
Oral Solution,Tablets
Adults. Initial: 20 mg q.i.d., increased gradually, as needed. Maximum: 240 mg daily.
As adjunct to treat hypertrophic cardiomyopathy
Oral Solution,Tablets
Adults. 20 to 40 mg t.i.d. or q.i.d., adjusted as needed.
As adjunct to manage pheochromocytoma
Oral Solution,Tablets
Adults. For operable tumors, 20 mg t.i.d. to 40 mg t.i.d. or q.i.d. for 3 days before surgery, concurrently with an alpha blocker.
For inoperable tumors, 30 to 160 mg daily in divided doses.
To prevent MI
Oral Solution,Tablets
Adults. 180 to 240 mg daily in divided doses.
Dosage Adjustment Dosage increased or decreased for elderly patients, depending on sensitivity to propranolol.
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Contraindications of Drug
Read contraindications if you want cheap Inderal LA (Propranolol) online.
Asthma, cardiogenic shock, greater than first-degree atrioventricular block, sick sinus syndrome, or sinus bradycardia (unless pacemaker in place); heart failure (unless secondary to tachyarrhythmia responsive to propranolol), hypersensitivity to propranolol or its components
Generic Drug Interactions
Drugs
ACE inhibitors: Increased risk of hypotension, especially in presence of acute MI allergen immunotherapy, allergenic extracts for skin testing: Increased risk of serious systemic adverse reactions or anaphylaxis
amiodarone: Additive depressant effects on conduction, negative inotropic effects
anesthetics (hydrocarbon inhalation):
Increased risk of myocardial depression and hypotension
beta blockers: Additive beta blockade effects
bupivacaine, lidocaine, mepivacaine: Decreased clearance of these drugs, possibly increased risk of toxicity
calcium channel blockers, clonidine, diazoxide, guanabenz, resperpine, other hypotension-producing drugs: Additive hypotensive effect and, possibly, other beta blockade effects
catecholamine-depleting drugs, such as reserpine: Increased risk of hypotension, bradycardia, vertigo, syncope, and orthostatic hypotension
cimetidine: Possibly interference with propranolol clearance
digitalis glycosides: Increased risk of bradycardia
diltiazem: Increased risk of bradycardia, hypotension, high-degree heart block, and heart failure
dobutamine, isoproterenol: Reversed effects of propranolol
doxazosin, terazosin: Increased risk of orthostatic hypotension
epinephrine: Increased risk of uncontrolled hypertension
estrogens: Decreased antihypertensive effect of propranolol
fentanyl, fentanyl derivatives: Possibly increased risk of initial bradycardia after induction doses of fentanyl or a derivative (with long-term propranolol use)
glucagon: Possibly blunted hyperglycemic response
insulin, oral antidiabetic drugs: Possibly impaired glucose control, masking of tachycardia in response to hypoglycemia
MAO inhibitors, tricyclic antidepressants: Increased risk of significant hypertension neuroleptic drugs: Increased risk of hypotension and cardiac arrest
neuromuscular blockers: Possibly potentiated and prolonged action of these drugs NSAIDs: Possibly decreased hypotensive effects
phenothiazines: Increased blood levels of both drugs
phenytoin: Additive cardiac depressant effects (with parenteral phenytoin) prazosin: Increased risk of first-dose hypotension
propafenone: Increased blood level and half-life of propranolol
quinidine: Increased propranolol level, resulting in higher degrees of beta blockade and orthostatic hypotension
sympathomimetics, xanthines: Possibly mutual inhibition of therapeutic effects thyroxine: Possibly decreased T3 level
verapamil: Increased risk of bradycardia, heart failure, and cardiovascular collapse warfarin: Increased risk of bleeding
Activities
alcohol: Possibly increased plasma propranolol level
nicotine chewing gum, smoking cessation, smoking deterrents: Increased therapeutic effects of propranolol
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Drugs Adverse Reactions
Central Nervous System: Anxiety, depression, dizziness, drowsiness, fatigue, fever, insomnia, lethargy, nervousness, weakness
Cardiovascular: atrioventricular conduction disorders, cold limbs, heart failure, hypotension, sinus bradycardia
Eyes, Ears, Nose, And Throat: Dry eyes, laryngospasm, nasal congestion, pharyngitis
Gastrointestinal: Abdominal pain, constipation, diarrhea, nausea, vomiting
Genitourinary: Impotence, peyronie's disease, sexual dysfunction
Hematologic: Agranulocytosis
Musculoskeletal: Muscle weakness
Respiratory: Bronchospasm, dyspnea, respiratory distress, wheezing
Skin: Alopecia, erythema multiforme, erythematous rash, exfoliative dermatitis, psoriasiform rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria
Other: Anaphylaxis, flulike symptoms, systemic lupuslike reaction
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Nursing Considerations for Generic Drugs
• Use propranolol cautiously in patients with bronchospastic lung disease because it may induce asthmatic attack.
• Monitor blood pressure, apical and radial pulses, fluid intake and output, daily weight, respiration, and circulation in extremities before and during therapy.
• Give intravenous injection at no more than 1 mg/ minute.
WARNING Monitor electrocardiogram continuously, as ordered, when giving intravenous injection. Have emergency drugs and equipment available in case of hypotension or cardiac arrest.
• Protect injection solution from light.
• Because drug's negative inotropic effect can depress cardiac output, monitor cardiac output in patients with heart failure, particularly those with severely compromised left ventricular dysfunction.
• Be aware that propranolol can mask tachycardia in hyperthyroidism and that abrupt withdrawal in patients with hyperthyroidism or thyrotoxicosis can cause thyroid storm.
• Monitor diabetic patient taking an antidiabetic because propranolol can prolong hypoglycemia or promote hyperglycemia. It also can mask signs of hypoglycemia, especially tachycardia, palpitations, and tremor, but it doesn't suppress diaphoresis or hypertensive response to hypoglycemia.
WARNING Be aware that stopping drug abruptly may cause myocardial ischemia, MI, ventricular arrhythmias, or severe hypertension, especially in patients with cardiac disease. It also may cause increased intraocular pressure to return. Dosage should be reduced gradually.
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Propranolol
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Prolonged-release Propranolol Capsules; Propranolol Injection; Propranolol Tablets;
The United States Pharmacopeia 31, 2008: Propranolol Hydrochloride and Hydrochlorothiazide Extendedrelease Capsules; Propranolol Hydrochloride and Hydrochlorothiazide Tablets; Propranolol Hydrochloride Extended-release Capsules; Propranolol Hydrochloride Injection; Propranolol Hydrochloride Tablets.
Proprietary Preparations
Argentina: Inderal; Pirimetan; Propalong; Propaneitor; Propayerst;
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