Lamisil (Terbinafine) - Anti-Fungus
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Top » Catalog » Anti-Fungus » Lamisil (Terbinafine)


Lamisil (Terbinafine)

$192.21


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Lamisil (Terbinafine)

Class and Category of Drug

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Chemical class: Allylamine derivative

Therapeutic class: Antifungal

Pregnancy category: B

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Drug Indications and Dosages

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To treat onychomycosis of fingernails and toenails

Tablets

Adults and adolescents. 125 mg b.i.d. or 250 mg daily for 6 to 12 wk.

Dosage Adjustment For patients with stable chronic hepatic dysfunction or renal dysfunction (creatinine clearance less than 50 ml/min/1.73 m2 or serum creatinine greater than 3.4 mg/dl), dosage reduced by 50%.

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Contraindications of Drug

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Hypersensitivity to terbinafine or its components

Generic Drug Interactions

Drugs

beta blockers, MAO inhibitors (type B), selective serotonin reuptake inhibitors, tricyclic antidepressants: Possibly increased blood levels of these drugs

cimetidine, other hepatic enzyme inhibitors: Significantly decreased terbinafine clearance, possibly increased adverse reactions hepatotoxic drugs: Increased risk of hepatotoxicity

rifampin: Increased clearance and decreased effectiveness of terbinafine

Foods

caffeine: Decreased caffeine clearance

Activities

alcohol use: Increased risk of severe hepatitis

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Drugs Adverse Reactions

Central Nervous System: Headache

Eyes, Ears, Nose, And Throat: Taste perversion

Gastrointestinal: Abdominal pain, anorexia, diarrhea, elevated liver function test results, flatulence, hepatic failure, indigestion, nausea, vomiting

Skin: Cutaneous lupus erythematosus, pruritus, rash, urticaria

Other: Angioedema, systemic lupus erythematosus

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Nursing Considerations for Generic Drugs

• Because terbinafine has been linked to serious adverse hepatic effects, expect to send nail specimens for laboratory testing to confirm onychomycosis before starting therapy.

• Be aware that drug shouldn't be given to patients with chronic or active hepatic disease or renal impairment.

• Monitor patient for hepatic failure (anorexia, dark urine, fatigue, jaundice, nausea, pale stools, right upper abdominal pain, and vomiting). Expect to stop drug and obtain liver function tests if these problems develop.

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Preparations

International Brand Drug Names

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