Medrol (Methylprednisolone)
Class and Category of Drug
Before you buy Medrol (Methylprednisolone) online, read common information about the medication.
Chemical class: Synthetic glucocorticoid
Therapeutic class: Anti-inflammatory, immunosuppressant
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Medrol (Methylprednisolone) online , you must read how it works.
To treat ulcerative colitis
Intravenous Infusion (Methylprednisolone Sodium Succinate)
Adults. 40 to 120 mg 3 to 7 times/wk for 2 or more wk. Later doses given intravenous or I.M.,
based on patient's condition and response.
Children. 0.14 to 0.84 mg/kg daily in divided doses every 12 to 24 hr.
To treat a wide range of immune and inflammatory disorders, including allergic rhinitis, asthma, Crohn's disease, and systemic lupus erythematosus
Tablets (Methylprednisolone )
Adults. 4 to 48 mg daily as a single dose or in divided doses.
Children. 0.42 to 1.67 mg/kg daily in divided doses t.i.d. or q.i.d.
I.V. Infusion, intramuscular Injection (Methylprednisolone Sodium Succinate)
Adults. Initial: 10 to 40 mg infused over several min. Later doses given intravenous or I.M., based on patient's condition and response. Children. 0.14 to 0.84 mg/kg every 12 to 24 hr.
I.M. Injection (Methylprednisolone Acetate)
Adults. 40 to 120 mg daily to every 2 wk, according to clinical response. Children. 0.14 to 0.84 mg/kg every 12 to 24 hr.
Intra-Articular, Intralesional, or Soft-tissue Injection (Methylprednisolone Acetate)
Adults. 4 to 80 mg every 1 to 5 wk, according to clinical response.
To treat adrenal hyperplasia intramuscular Injection (Methylprednisolone Acetate) Adults. 40 mg every 2 wk. Children. 0.14 to 0.84 mg/kg every 12 to 24 hr.
To treat acute exacerbations of multiple
Sclerosis Tablets (Methylprednisolone )
Adults. 160 mg daily for 7 days followed by 64 mg every other day for 1 mo.
Intravenous or Intramuscular Injection (Methylprednisolone Acetate, Methylprednisolone Sodium Succinate)
Adults. 160 mg daily for 1 wk followed by 64 mg every other day for 1 mo.
To treat adrenocortical insufficiency
Tablets (Methylprednisolone ), intramuscular Injection (Methylprednisolone Sodium Succinate)
Children. 0.18 mg/kg daily in divided doses t.i.d.
I.M. Injection (Methylprednisolone Acetate)
Children. 0.12 mg/kg every 3 days or 0.039 to 0.059 mg/kg daily.
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Incompatibilities
Don't mix methylprednisolone with any drug without first consulting pharmacist. Don't dilute methylprednisolone acetate with any other drug.
Contraindications of Drug
Read contraindications if you want cheap Medrol (Methylprednisolone) online.
Fungal infection, hypersensitivity to methylprednisolone or its components, idiopathic thrombocytopenic purpura (I.M.)
Generic Drug Interactions
Drugs
acetaminophen: Increased risk of hepatotoxicity
aminoglutethimide: Possibly loss of methylprednisolone-induced adrenal suppression
amphotericin B, carbonic anhydrase inhibitors: Possibly severe hypokalemia
anabolic steroids, androgens: Increased risk of edema and worsening of acne anticholinergics: Possibly increased intraocular pressure
asparaginase: Increased risk of hyperglyce-mia and toxicity
aspirin, NSAIDs: Increased risk of adverse gastrointestinal effects and bleeding barbiturates, carbamazepine, phenytoin, rifampin: Decreased blood methylprednisolone level
cholestyramine: Possibly increased methylprednisolone clearance
cyclosporine: Increased risk of seizures
digoxin: Possibly hypokalemia-induced arrhythmias and digitalis toxicity
estrogens, oral contraceptives: Possibly increased therapeutic and toxic effects of methylprednisolone
insulin, oral antidiabetic drugs: Possibly increased blood glucose level isoniazid: Possibly decreased therapeutic effects of isoniazid
ketoconazole, macrolide antibiotics such as erythromycin and troleandomycin: Decreased methylprednisolone clearance and increased risk of adverse effects mexiletine: Possibly decreased blood mexiletine level
neuromuscular blockers: Possibly increased neuromuscular blockade, causing respiratory depression or apnea oral anticoagulants, thrombolytics: Increased risk of gastrointestinal ulceration and hemorrhage, possibly decreased therapeutic effects of these drugs
potassium supplements: Possibly decreased effects of these supplements somatrem, somatropin: Possibly decreased therapeutic effects of these drugs streptozocin: Increased risk of hyperglycemia
troleandomycin: Increased blood methylprednisolone level
vaccines: Decreased antibody response and increased risk of neurologic complications
Activities
alcohol use: Increased risk of adverse gastrointestinal effects and bleeding
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Drugs Adverse Reactions
Central Nervous System: Ataxia, behavioral changes, depression, dizziness, euphoria, fatigue, headache, increased intracranial pressure with papilledema, insomnia, malaise, mood changes, neuropathy, paresthesia, restlessness, seizures, steroid psychosis, syncope, vertigo
Cardiovascular: Arrhythmias (from hypokalemia), cardiac arrest, edema, fat embolism, heart failure, hypertension, hypertrophic cardiomyopathy (premature infants), hypotension, myocardial rupture following recent MI, tachycardia, thromboembolism, thrombophlebitis
Eyes, Ears, Nose, And Throat: Exophthalmos, glaucoma, increased intraocular pressure, nystagmus, posterior subcapsular cataracts
Endocrine: Adrenal insufficiency, cushingoid symptoms (moon face, buffalo hump, central obesity, supraclavicular fat pad enlargement), diabetes mellitus, growth suppression in children, hyperglycemia, negative nitrogen balance from protein catabolism
Gastrointestinal: Abdominal distention, elevated liver enzymes, hepatomegaly, hiccups, increased appetite, melena, nausea, pancreatitis, peptic ulcer, ulcerative esophagitis, vomiting
Genitourinary: Amenorrhea, glycosuria, menstrual irregularities, perineal burning or tingling
Hematologic: Easy bruising, leukocytosis
Musculoskeletal: Arthralgia; aseptic necrosis of femoral and humeral heads; Charcot-like arthropathy; compression fractures; muscle atrophy, twitching, or weakness; myalgia; osteoporosis; spontaneous fractures; steroid myopathy; tendon rupture
Respiratory: Pulmonary edema
Skin: Acne; allergic dermatitis; altered skin pigmentation; diaphoresis; dry, scaly skin; erythema; hirsutism; necrotizing vasculitis; petechiae; purpura; rash; scarring; sterile abscess; striae; subcutaneous fat atrophy; thin, fragile skin; urticaria
Other: Activation of latent infections, anaphylaxis, angioedema, exacerbation of systemic fungal infections, hypernatremia, hypocalcemia, hypokalemia, hypokalemic alkalosis, impaired wound healing, masking of signs of infection, metabolic alkalosis, suppressed skin test reaction, weight gain
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