Methotrexate (Amethopterin)
Class and Category of Drug
Before you buy Methotrexate (Amethopterin) online, read common information about the medication.
Chemical class: Folk acid analogue
Therapeutic class: Antipsoriatic, anti-rheumatic
Pregnancy category: X
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Drug Indications and Dosages
Before purchase Methotrexate (Amethopterin) online , you must read how it works.
To treat severe psoriasis unresponsive to other therapy
Tablets (Methotrexate) Adults. 2.5 to 5 mg every 12 hr for 3 doses/ wk, increased as ordered by 2.5 mg/wk. Maximum: 20 mg/wk.
Intravenous or Intramuscular Injection (Methotrexate Sodium)
Adults. 10 mg/wk. Maximum: 25 mg/wk.
To treat severe rheumatoid arthritis unresponsive to other therapy
Tablets (Methotrexate) Adults. 2.5 to 5 mg every 12 hr for 3 doses/ wk, increased as ordered by 2.5 mg/wk. Maximum: 20 mg/wk.
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Contraindications of Drug
Read contraindications if you want cheap Methotrexate (Amethopterin) online.
Breast-feeding, hypersensitivity to methotrexate or its components, pregnancy
Generic Drug Interactions
Drugs
bone marrow depressants: Possibly increased
bone marrow depression
co-trimoxazole: Possibly increased bone marrow suppression
folk acid: Possibly decreased effectiveness of methotrexate
hepatotoxic drugs: Increased risk of hepatotoxicity
chloramphenicol, neomycin, tetracycline: Possibly decreased methotrexate absorption
NSAIDs, penicillins, phenylbutazone, phenytoin, probenecid, salicylates, sulfonamides: Increased risk of methotrexate toxkity
oral anticoagulants: Increased bleeding risk
sulfonamides: Increased risk of hepatotoxicity
theophylline: Possibly increased risk of theophylline toxkity
vaccines: Risk of disseminated infection with live-virus vaccines, risk of suppressed response to killed-virus vaccines
Activities
alcohol use: Increased risk of hepatotoxicity
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Drugs Adverse Reactions
Central Nervous System: Aphasia, cerebral thrombosis, chills, dizziness, drowsiness, fatigue, fever, headache, hemiparesis, leukoencephalopathy, malaise, paresis, seizures
Cardiovascular: Chest pain, deep vein thrombosis, hypotension, perkardial effusion, pericarditis, thromboembolism
Endocrine: Gynecomastia
Eyes, Ears, Nose, And Throat: Blurred vision, conjunctivitis, gingivitis, glossitis, pharyngitis, stomatitis, transient blindness, tinnitus
Gastrointestinal: Abdominal pain, anorexia, cirrhosis, diarrhea, elevated liver function test results, enteritis, gastrointestinal bleeding and ulceration, hepatitis, hepatotoxicity, nausea, pancreatitis, vomiting
Genitourinary: Cystitis, hematuria, infertility, menstrual dysfunction, nephropathy, renal failure, tubular necrosis, vaginal discharge
Hematologic: Anemia, aplastic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia
Musculoskeletal: Arthralgia, dysarthia, myalgia, stress fracture
Respiratory: Dry nonproductive cough, dyspnea, interstitial pneumonitis, pneumonia, pulmonary fibrosis or failure, pulmonary infiltrates
Skin: Acne, alopecia, altered skin pigmentation, ecchymosis, erythema multiforme, exfoliative dermatitis, furunculosis, necrosis, photosensitivity, pruritus, psoriatic lesions, rash, Stevens-Johnson syndrome, telangiectasia, toxic epidermal necrolysis, ulceration, urticaria
Other: Anaphylaxis, increased risk of infection, lymphadenopathy, lymphoproliferative disease
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Nursing Considerations for Generic Drugs
• Follow facility policy for preparing and handling drug; parenteral form poses a risk of carcinogenicity, mutagenicity, and teratogenicity. Avoid skin contact.
• Monitor results of CBC, chest X-ray, liver and renal function tests, and urinalysis before and during treatment.
• Unless contraindicated, increase patient's fluid intake to 2 to 3 L daily to reduce the risk of adverse genitourinary reactions.
• Assess patient for bleeding and infection.
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Methotrexate
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Methotrexate Injection; Methotrexate Tablets;
The United States Pharmacopeia 31, 2008: Methotrexate for Injection; Methotrexate Injection; Methotrexate Tablets.
Proprietary Preparations
Argentina: Artrait; Ervemin; Trixate; Xantromid;
Australia: Ledertrexate; Methoblastin;
Austria: Ebetrexat; Emthexate;
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Belgium: Emthexate; Ledertrexate;
Brazil: Biometrox; Emthexate; Metrexato; Miantrex; Reutrexato; Tecnomet; Trexeron; Unitrexate;
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Chile: Trixilem;
Czech Republic: Metoject;
Denmark: Emthexate; Metoject;
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Finland: Emthexat; Metoject; Trexan;
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France: Ledertrexate; Novatrex;
Germany: Farmitrexat; Lantarel; Metex; MTX; O-trexat;
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Greece: Emthexate; Methobion; Metoject;
Hungary: Metoject; Trexan;
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India: Biotrexate; Caditrex; Imutrex; Methocip; Neotrexate;
Indonesia: Emthexate; Israel: Abitrexate;
Japan: Metolate;
Malaysia: Emthexate;
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Mexico: Atrexel; Ifamet; Ledertrexate; Leulin; Medsatrexate; Methoblastin; Otaxem; Texate; Trixilem;
Netherlands or Holland: Emthexate; Ledertrexate; Metoject;
Norway: Emthexat; Metoject;
New Zealand: Emthexate; Ledertrexate; Methoblastin;
Philippines: Emthexate; Hextrate; Methobax; Pterin; Zexate;
Poland: Trexan;
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Portugal: Fauldexato; Metoject;
Russia: Trixilem (Триксилем);
South Africa:
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France: Abitrexate; Emthexate;
Spain: Emthexate; Metoject;
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Sweden: Emthexat; Metoject;
Thailand: Abitrexate; Emthexate; Trixilem; Zexate;
Turkey: Emthexate; Trexan;
UK or Britain: Maxtrex; Metoject;
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US or USA: Rheumatrex; Trexall;
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Venezuela: Zexate.
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