Nolvadex (Tamoxifen)
Class and Category of Drug
Before you buy Nolvadex (Tamoxifen) online, read common information about the medication.
Chemical class: Triphenylethylene derivative
Therapeutic class: Nonsteroidal antiestrogen agent, partial estrogen agonist
Pregnancy category: D
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Drug Indications and Dosages
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To treat metastatic breast cancer in men and women; to treat node-negative breast cancer in women, or node-positive breast cancer in postmenopausal women, after total or segmental mastectomy, axillary dissection, and breast irradiation
Tablets
Adults. 20 to 40 mg daily. Dosages greater
than 20 mg administered b.i.d.
To reduce the risk of invasive breast cancer in women with ductal carcinoma in situ (DCIS) after surgery and radiation, to reduce the risk of breast cancer in women at high risk
Tablets
Adults. 20 mg daily for 5 yr.
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Contraindications of Drug
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Hypersensitivity to tamoxifen or its components; women at high risk for breast cancer and women with ductal carcinoma in situ and a history of deep vein thrombosis or pulmonary embolus or who need coumarin-type anticoagulant therapy; use with anastrozole therapy
Generic Drug Interactions
Drugs
bromocriptine: Possibly increased blood tamoxifen level
estrogens: Possibly altered therapeutic effect of tamoxifen
warfarin and other coumarin-type anticoagulants: Increased anticoagulant effect of these drugs
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Drugs Adverse Reactions
Central Nervous System: Confusion, depression, dizziness, fatigue, headache, light-headedness, somnolence, stroke, weakness
Cardiovascular: Edema, hyperlipidemia, thrombosis
Eyes, Ears, Nose, And Throat: Keratopathy, ocular toxicity (including cataracts), optic neuritis, retinopathy
Gastrointestinal: Elevated liver function test results, hepatotoxicity, nausea, vomiting
Genitourinary: Endometrial cancer, endometrial hyperplasia, endometrial polyps, genital itching, menstrual irregularities, ovarian cysts, uterine malignancies, Vaginal discharge (females); impotence, decreased libido (males)
Hematologic: Anemia, leukopenia, thrombocytopenia
Musculoskeletal: Transient bone or tumor pain
Respiratory: Pulmonary embolism
Skin: Bullous pemphigoid, dry skin, erythema multiforme, rash, Stevens-Johnson syndrome, thinning hair
Other: Angioedema, hot flashes, hypercalcemia, weight gain
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Nursing Considerations for Generic Drugs
WARNING Make sure that patient has been informed about serious or potentially life-threatening adverse effects associated with tamoxifen before therapy begins. Be aware that women with ductal carcinoma in situ and those at high risk for breast cancer are more likely to develop uterine cancer, stroke, or pulmonary emboli than others receiving tamoxifen.
• If patient is premenopausal, begin drug therapy in the middle of menstruation; if patient's menstrual cycles are irregular, verify that she has had a negative pregnancy test before therapy starts.
• Expect patient to undergo an ophthalmic examination before and periodically during tamoxifen therapy. Also expect to monitor patient for adverse ocular reactions, such as cataracts.
• Assess patient for signs and symptoms of thromboembolic events, such as shortness of breath, leg pain, and change in mental status.
• Periodically monitor patient's platelet and WBC counts, cholesterol and triglyceride levels, and liver function test results, as ordered.
• Monitor blood calcium level and assess
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Tamoxifen
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Tamoxifen Tablets;
The United States Pharmacopeia 31, 2008: Tamoxifen Citrate Tablets.
Proprietary Preparations
Argentina: Crisafeno; Diemon; Farmifeno; Ginarsan; Nolvadex; Rolap; Tamofen; Tamoxis; Taxfeno; Trimetrox;
Australia: Genox; Nolvadex; Tamosin; Tamoxen;
Austria: Ebefen; Kessar; Nolvadex; Tamax; Tamofen; Tamoplex;
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Belgium: Doctamoxifene; Nolvadex; Tamizam; Tamoplex;
Brazil: Bioxifeno; Estrocur; Festone; Kessar; Nolvadex; Tamooex; Tamoplex; Tamox; Tamoxin; Taxofen; Tecnotax;
Canada: Apo-Tamox; Nolvadex; Tamofen;
The pharmaceutical companies our pharmacies buy from follow strict WHO standards for GMP.
Chile: Kessar; Nolvadex; Oncotamox; Tamolem; Taxus;
Czech Republic: Nolvadex; Tamifen; Tamoplex; Zitazonium;
Denmark: Tamofen;
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Finland: Nolvadex; Tadex; Tamexin; Tamofen;
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France: Kessar; Nolvadex; Oncotam; Tamofene;
Germany: Jenoxifen; Kessar; Mandofen; Nolvadex; Nourytam; Tamokadin; Tamopham; Tamox; Tamoxasta; Tamoximerck; Tamoxistad; Zemide;
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Greece: Adifen; Defarol; Kessar; Nolvadex; Puretam; Tamoplex; Zymoplex;
Hong Kong: Apo-Tamox; Nolvadex; Novofen; Tamifen; Zitazonium;
Hungary: Zitazonium;
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India: Caditam; Cytotam; Mamofen; Nolvadex; Tamodex;
Indonesia: Nolvadex; Tamofen; Tamoplex; Taxen;
Ireland: Nolgen; Nolvadex; Tamofen; Tamox; Israel: Nolvadex; Tamofen; Tamoxen; Tamoxi;
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Italy: Kessar; Ledertam; Nolvadex; Nomafen; Tamoxene; Virtamox;
Malaysia: Genox; Nolvadex; Novofen; Tamoplex; Zitazonium;
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Mexico: Bilem; Cryoxifeno; Fenobest; Kessar; Nolvadex; Ralsifen-X; Tamoxan; Taxus; Tecnofen;
Netherlands or Holland: Nolvadex;
Norway: Nolvadex;
New Zealand: Genox; Nolvadex; Tamofen;
Philippines: Fenahex; Gynatam; Gyraxen; Kessar; Nolvadex; Tamoplex; Tamoxsta; Zitazonium;
Poland: Nolvadex;
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Portugal: Mastofen; Nolvadex; Tamoxan;
Russia: Bilem (Билем); Tamifen (Тамифен); Zitazonium (Зитазониум);
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France: Kessar; Neophedan; Nolvadex; Tamoplex;
Singapore: Apo-Tamox; Nolvadex; Tamofen;
Spain: Nolvadex; Sinmaren; Yacesal;
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Sweden: Nolvadex;
Switzerland: Kessar; Nolvadex; Tamec;
Thailand: Bilem; Gynatam; Nolvadex; Novofen; Tamofen; Tamoplex; Tuosomin; Zitazonium;
Turkey: Nolvadex; Tadex; Tamofen; UAE: Tamophar;
UK or Britain: Nolvadex; Soltamox;
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Venezuela: Gynatam; Nolvadex; Taxus.
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