Noroxin (Norfloxacin)
Class and Category of Drug
Before you buy Noroxin (Norfloxacin) online, read common information about the medication.
Chemical class: Fluoroquinolone
Therapeutic class: Antibiotic
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Noroxin (Norfloxacin) online , you must read how it works.
To treat uncomplicated Urinary tract infection caused by Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis
Tablets
Adults. 400 mg every 12 hr for 3 days.
To treat uncomplicated Urinary tract infection caused by Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Enterococcus faecalis, Proteus species, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus, or Streptococcus agalactiae
Tablets
Adults. 400 mg every 12 hr for 7 to 10 days.
To treat complicated Urinary tract infection caused by E. coli, E. faecalis, K. pneumoniae, P. aeruginosa, P. mirabilis, or Serratia marcescens
Tablets
Adults. 400 mg every 12 hr for 10 to 21 days. Maximum: 800 mg daily.
To treat uncomplicated gonorrhea
Tablets
Adults. 800 mg as a single dose.
To treat prostatitis caused by E. coli
Tablets
Adults. 400 mg every 12 hr for 28 days.
Dosage Adjustment
Dosage reduced to 400 mg daily for patients with creatinine clearance of 30 ml/min/1.73 m2 or less.
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Contraindications of Drug
Read contraindications if you want cheap Noroxin (Norfloxacin) online.
Hypersensitivity to norfloxacin, other fluoroquinolones, or their components
Generic Drug Interactions
Drugs
aluminum-, calcium-, or magnesium-containing antacids; ferrous sulfate; magnesium-containing laxatives; sucralfate; zinc: Possibly decreased absorption and blood level of norfloxacin
caffeine, clozapine, ropinirole, tacrine, theophylline, tizanidine: Possibly increased blood level of these drugs
class IA antiarrhythmics, such as quinidine; class III antiarrhythmics, such as sotalol; other drugs known to prolong QTc interval, such as disopyramide and pentamidine: Possibly prolonged QTc interval
cyclosporine: Possibly increased serum creatinine and blood cyclosporine levels didanosine: Possibly decreased norfloxacin absorption
glyburide: Risk of severe hypoglycemia
nitrofurantoin: Possibly decreased norfloxacin effectiveness
NSAIDs: Possibly increased risk of CNS stimulation and seizures
probenecid: Decreased norfloxacin excretion and risk of toxicity
warfarin: Possibly increased anticoagulant effect and risk of bleeding
Foods
caffeine: Reduced clearance of caffeine leading to accumulation of caffeine in blood
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Drugs Adverse Reactions
Central Nervous System: Ataxia, confusion, dizziness, drowsiness, fever, Guillian-Barre syndrome, headache, hypoesthesia, insomnia, pares-thesia, peripheral neuropathy, psychosis, seizures, tremors
Cardiovascular: Prolonged QT interval, torsades de pointes, vasculitis
Eyes, Ears, Nose, And Throat: Decreased taste sensation, diplopia, hearing loss, stomatitis, taste perversion, tinnitus, visual changes
Gastrointestinal: Abdominal cramps or pain, acute hepatic necrosis or failure, diarrhea, elevated liver function test results, hepatitis, jaundice, nausea, pancreatitis, pseudomembranous colitis, vomiting
Genitourinary: Interstitial nephritis, renal failure, Vaginal candidiasis
Hematologic: Agranulocytosis, aplastic anemia, heinolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia
Musculoskeletal: Arthralgia; myasthenia gravis exacerbation; myalgia; tendinitis; tendon inflammation, pain, or rupture
Respiratory: Allergic pneumonitis, dyspnea
Skin: Blisters, diaphoresis, erythema, erythema multiforme, exfoliative dermatitis, photosensitivity, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria
Other: Anaphylaxis, angioedema, serum sickness
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Nursing Considerations for Generic Drugs
• Obtain urine specimen for culture and sensitivity tests before starting drug, if possible.
• Determine if patient has a history of CNS disorder because drug may lower seizure threshold. Notify prescriber before starting drug, and institute seizure precautions.
WARNING Before starting therapy, determine if patient takes a class IA antiarrhythmic, such as quinidine; a class III antiarrhythmic, such as sotalol; or other drugs that prolong the QTc interval. Also find out if patient has hypokalemia or an underlying QT-interval prolonging condition. These drugs and conditions, especially in the elderly, may prolong the QTc interval and lead to life-threatening ventricular tachycardia or torsades de pointes in a patient taking norfloxacin.
• Give drug on an empty stomach 2 hours before or after antacids, didanosine, sucralfate, or vitamins that contain iron or zinc.
• Keep emergency resuscitation equipment readily available, and watch for signs of hypersensitivity, such as angioedema, dyspnea, jaundice, rash, and urticaria. If you suspect anaphylaxis, prepare to give epinephrine, corticosteroids, and diphenhydramine, as prescribed.
• If patient has myasthenia gravis, assess her often for a change in respiratory status because drug may lead to life-threatening weakness of respiratory muscles.
• Notify prescriber if patient has symptoms of peripheral neuropathy (pain, burning, tingling, numbness, weakness, or altered sensations of light touch, pain, temperature, position sense, or vibration sense), which could be permanent. Expect to stop nofloxacin.
• Monitor patients prone to tendinitis, such as the elderly, athletes, and those taking corticosteroids, for complaints of tendon pain, inflammation, or rupture. If present, notify prescriber and expect to discontinue norfloxacin, place patient on bedrest with no exercise of affected limb, and obtain diagnostic tests to confirm rupture.
• Monitor patient for diarrhea, which may indicate pseudomembranous colitis caused by Clostridium difficile. If diarrhea occurs, notify prescriber and expect to withhold norfloxacin and treat with fluids, electrolytes, protein, and an antibiotic effective against C. difficile.
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Norfloxacin
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Norfloxacin Eye Drops; Norfloxacin Tablets;
The United States Pharmacopeia 31, 2008: Norfloxacin Ophthalmic Solution; Norfloxacin Tablets.
Proprietary Preparations
Argentina: Bio Tarbun; Chibroxin; Floxamicin; Floxatral; Memento NF; Norflol; Noroxin; Norsol; Parcetin; Ritromine; Uro-Linfol; Urofos; Uronovag; Uroseptal; Urotem; Uroxacin; Wenflox; Yanurax;
Australia: Insensye; Norflohexal; Noroxin; Nufloxib; Roxin;
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