Plavix (Clopidogrel)
Class and Category of Drug
Before you buy Plavix (Clopidogrel) online, read common information about the medication.
Chemical class: Thienopyridine derivative
Therapeutic class: Platelet aggregation inhibitor
Pregnancy category: B
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Drug Indications and Dosages
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To reduce atherosclerotic events, such as stroke and MI, in patients with atherosclerosis documented by recent stroke, MI, or peripheral artery disease
Tablets
Adults. 75 mg daily.
To reduce atherosclerotic events, such as stroke and MI, in patients with acute coronary syndrome (unstable angina or non-Q-wave MI)
Tablets
Adults. Loading dose: 300 mg. Maintenance: 75 mg daily.
To reduce rate of death, reinfarction, or stroke in patients with ST-segment elevation acute MI
Tablets
Adults. 75 mg once daily. Or, loading dose of 300 mg followed by 75 mg once daily.
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Contraindications of Drug
Read contraindications if you want cheap Plavix (Clopidogrel) online.
Active pathological bleeding, including peptic ulcer and intracranial hemorrhage; hypersensitivity to clopidogrel or its components
Generic Drug Interactions
Drugs
aspirin: Increased risk of bleeding
CYP2C19 inhibitors, such as cimetidine, esomeprazole, etravirine, felbamate, fluconazole, fluoxetine, fluvoxamine, ketoconazole, omeprazole, ticlopidine, voriconazole: Decreased plasma clopidogrel level, decreased platelet inhibition
fluvastatin, phenytoin, tamoxifen, tolbutamide, torsemide: Interference with metabolism of these drugs
NSAIDs: Increased risk of gastrointestinal bleeding, interference with NSAID metabolism
warfarin: Prolonged bleeding time, interference with warfarin metabolism
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Drugs Adverse Reactions
Central Nervous System: Confusion, depression, dizziness, fatigue, hallucinations, headache
Cardiovascular: Chest pain, edema, hypercholesterolemia, hypertension, hypotension, vasculitis
Eyes, Ears, Nose, And Throat: Altered taste; conjunctival, ocular, or retinal bleeding; epistaxis; rhinitis; taste disorders
Gastrointestinal: Abdominal pain; acute liver failure; colitis; diarrhea; duodenal, gastric, or peptic ulcer; elevated liver function test results; gastritis; indigestion; nausea; noninfectious hepatitis; pancreatitis
Genitourinary: Elevated serum creatinine level, glomerulopathy, urinary tract infection
Hematologic: Agranulocytosis, aplastic anemia, neutropenia, pancytopenia, prolonged bleeding time, thrombocytopenic purpura, thrombotic thrombocytopenic purpura, unusual bleeding or bruising
Musculoskeletal: Arthralgia, back pain, myalgia
Respiratory: Bronchitis, bronchospasm, cough, dyspnea, interstitial pneumonitis, upper respiratory tract infection
Skin: Erythema multiforme, lichen planus, pruritus, purpura, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis
Other: Anaphylaxis, angioedema, flulike symptoms, serum sickness
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Nursing Considerations for Generic Drugs
• Avoid clopidogrel in patients who have a genetic variation in CYP2C19 or are receiving CYP2C19 inhibitors. Platelet inhibition may decline, increasing the risk of adverse cardiovascular effects after MI.
• Use clopidogrel cautiously in patients with severe hepatic or renal disease, risk of bleeding from trauma or surgery, or conditions that predispose to bleeding (such as peptic ulcer disease or thrombotic thrombocytopenic purpura).
• In patient with acute coronary syndrome, expect to give aspirin with clopidogrel.
WARNING Clopidogrel prolongs bleeding time; expect to stop it 5 days before elective surgery.
• Obtain blood cell count, as ordered, whenever signs and symptoms suggest a hematologic problem.
• Monitor patient who takes aspirin closely because risk of bleeding is increased.
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Clopidogrel
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
The United States Pharmacopeia 31, 2008: Clopidogrel Tablets.
Proprietary Preparations
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