Prandin (Repaglinide)
Class and Category of Drug
Before you buy Prandin (Repaglinide) online, read common information about the medication.
Chemical class: Meglitinide
Therapeutic class: Antidiabetic
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Prandin (Repaglinide) online , you must read how it works.
To achieve glucose control in type 2 diabetes mellitus as monotherapy in patients whose glycosylated hemoglobin (HbAlc) level is less than 8%
Tablets
Adults. Initial: 0.5 mg 15 to 30 min before meals b.i.d. Dosage doubled, as needed, every wk until adequate glucose response obtained. Maintenance: 0.5 to 4 mg/dose up to q.i.d. Maximum: 16 mg daily in divided doses of not more than 4 mg/dose.
To achieve glucose control in type 2 diabetes mellitus as monotherapy in patients whose HbAlc is 8% or greater and in combination with metformin or thiazolidinedione (pioglitazone hydrochloride, rosiglitazone maleate) therapy
Tablets
Adults. Initial: 1 or 2 mg 15 to 30 min before meals b.i.d. Dosage doubled, as needed, every wk until adequate glucose response obtained. Maintenance: 1 to 4 mg/ dose up to q.i.d. Maximum: 16 mg daily in divided doses of not more than 4 mg/dose.
Dosage Adjustment For patients with moderate to severe hepatic or renal impairment, increased time between dosage adjustments.
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Contraindications of Drug
Read contraindications if you want cheap Prandin (Repaglinide) online.
Concurrent therapy with gemfibrozil, diabetic ketoacidosis, hypersensitivity to repaglinide or its components, severe hepatic or renal impairment, type 1 diabetes mellitus
Generic Drug Interactions
Drugs
barbiturates, carbamazepine, rifampin, troglitazone: Possibly increased repaglinide metabolism
beta blockers, chloramphenicol, clarithromycin, MAO inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), oral anticoagulants, probenecid, salicylates, sulfonamides: Enhanced hypoglycemic effects
calcium channel blockers, corticosteroids, diuretics, estrogens, isoniazid, niacin, oral contraceptives, phenothiazines, phenytoin, sympathomimetics, thyroid hormones: Possibly loss of glucose control
erythromycin, ketoconazole, miconazole: Possibly inhibited repaglinide metabolism gemfibrozil: Increased blood repaglinide level, resulting in enhanced and prolonged blood glucose-lowering effects
NPH insulin: Possibly increased risk of angina
OATP1B1 inhibitors such as cyclosporine,
trimethoprim: Increased plasma repaglinide level
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Drugs Adverse Reactions
Central Nervous System: Headache
Cardiovascular: Angina
Eyes, Ears, Nose, And Throat: Rhinitis, sinusitis
Endocrine: Hypoglycemia
Gastrointestinal: Diarrhea, elevated liver enzymes, hepatitis, nausea, pancreatitis
Hematologic: Hemolytic anemia, leukopenia, thrombocytopenia
Musculoskeletal: Arthralgia, back pain
Respiratory: Bronchitis, upper respiratory tract infection
Skin: Alopecia, Stevens-Johnson syndrome
Other: Anaphylaxis
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Nursing Considerations for Generic Drugs
• Be aware that repaglinide shouldn't be used with NPH insulin because the combination may increase the risk of angina.
• Expect to check HbAlc level every 3 months, as ordered, to assess patient's long-term control of blood glucose level.
• During times of increased stress, such as from infection, surgery, or trauma, monitor blood glucose level often and assess need for additional insulin.
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Repaglinide
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
The United States Pharmacopeia 31, 2008: Repaglinide Tablets.
Proprietary Preparations
Argentina: Glukenil; NovoNorm; Sestrine;
Australia: NovoNorm;
Austria: NovoNorm;
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Brazil: Gluconorm; NovoNorm; Prandin;
Canada: Gluconorm;
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Chile: Hipover; NovoNorm;
Czech Republic: NovoNorm; Prandin;
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France: NovoNorm;
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US or USA: Prandin.
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