Prednisolone
Class and Category of Drug
Before you buy Prednisolone online, read common information about the medication.
Chemical class: Glucocorticoid
Therapeutic class: Anti-inflammatory, immunosuppressant
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Prednisolone online , you must read how it works.
To treat adrenal insufficiency and acute and chronic inflammatory and immunosuppressive disorders
Adults and adolescents. 5 to 60 mg daily or in divided doses. Maximum: 250 mg daily.
Intramuscular Injection (Prednisolone Acetate)
Adults and adolescents. 4 to 60 mg daily.
Intra-Articular, Intralesional, or Soft-tissue Injection (Prednisolone Acetate, Prednisolone Tebutate)
Adults and adolescents. 4 to 100 mg of prednisolone acetate, repeated as needed, or 4 to 40 mg of prednisolone tebutate, repeated every 1 to 3 wk, as needed.
To treat adrenocortical insufficiency in children
SYRUP, TABLETS (PREDNISOLONE); DISINTEGRATING TABLETS, ORAL SOLUTION (PREDNISOLONE SODIUM PHOSPHATE); ORAL SUSPENSION (PREDNISOLONE ACETATE)
Children. 0.14 mg/kg daily in divided doses t.i.d.
I.M. Injection (Prednisolone Acetate)
Children. 0.14 mg/kg over a 24-hr period in divided doses t.i.d. every third day.
To treat acute exacerbations of multiple sclerosis
Syrup,Tablets (Prednisolone); Disintegrating Tablets, Oral Solution (Prednisolone Sodium Phosphate); Oral Suspension (Prednisolone Acetate)
Adults. 200 mg daily for 1 wk, followed by 80 mg every other day for 1 mo.
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Contraindications of Drug
Read contraindications if you want cheap Prednisolone online.
Hypersensitivity to prednisolone or its components, idiopathic thrombocytopenic purpura (I.M. form), systemic fungal infection
Generic Drug Interactions
Drugs
acetaminophen: Possibly hepatotoxicity (long-term use or high acetaminophen doses)
acetazolamide: Possibly hypernatremia or edema
amphotericin B (parenteral): Possibly severe hypokalemia
anabolic steroids, androgens: Possibly edema and severe acne
anticholinergics: Increased intraocular pressure asparaginase: Increased hyperglycemic
effect of asparaginase, possibly neuropathy and disturbances in erythropoiesis carbonic anhydrase inhibitors: Possibly hypocalcemia, hypokalemia, and osteoporosis digoxin: Possibly arrhythmias and digitalis toxicity from hypokalemia
diuretics: Possibly decreased natriuretic and diuretic effects of diuretics, severe hypokalemia (with potassium-depleting diuretics)
ephedrine: Increased metabolic clearance of prednisolone
estrogens, oral contraceptives: Decreased clearance, increased elimination half-life, and increased therapeutic and toxic effects of prednisolone
folk acid: Increased folk acid requirements (with long-term prednisolone use) heparin, oral anticoagulants, streptokinase, urokinase: Possibly decreased anticoagulant effect and increased risk of gastrointestinal ulceration and bleeding
immunosuppressants: Increased risk of infection, lymphomas, and other lymphoproliferative disorders
isoniazid: Decreased blood isoniazid level
mexiletine: Possibly accelerated metabolism and decreased blood level of mexiletine neuromuscular blockers: Increased neuromuscular blockade
NSAIDs: Increased risk of gastrointestinal ulceration and bleeding, possibly added therapeutic effect when NSAIDs are used to treat arthritis
potassium supplements: Decreased effectiveness of both drugs
rifampin, other hepatic enzyme inducers: Decreased prednisolone effect
ritodrine: Increased risk of pulmonary edema in pregnant women
salicylates: Possibly decreased blood salicylate level, increased risk of gastrointestinal ulceration and bleeding
sodium-containing drugs: Possibly edema and hypertension
somatrem, somatropin: Inhibited growth response to somatrem or somatropin streptozocin: Increased risk of hyperglycemia
toxoids, vaccines: Possibly loss of antibody response, increased risk of neurologic complications
tricyclic antidepressants: Possibly worsened adverse psychiatric effects of prednisolone troleandomycin: Increased therapeutic and toxic effects of prednisolone
Foods
sodium-containing foods: Increased risk of edema and hypertension
Activities
alcohol use: Increased risk of gastrointestinal ulceration and bleeding
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Drugs Adverse Reactions
Central Nervous System: Euphoria, headache, insomnia, nervousness, psychosis, restlessness, seizures, vertigo
Cardiovascular: Edema, heart failure, hypertension
Eyes, Ears, Nose, And Throat: Cataracts, exophthalmos, glaucoma, increased ocular pressure
Endocrine: Adrenal insufficiency, Cushing's syndrome, growth suppression in children, hyperglycemia
Gastrointestinal: Anorexia, gastrointestinal bleeding and ulceration, increased appetite, indigestion, intestinal perforation, nausea, pancreatitis, vomiting
Genitourinary: Menstrual irregularities
Musculoskeletal: Avascular necrosis of joints, bone fractures, muscle atrophy or weakness, myalgia, osteoporosis, tendon rupture (local injection only)
Skin: Acne; cutaneous or subcutaneous atrophy (with frequent repository injections); diaphoresis; ecchymosis; flushing; petechiae; striae; thin, fragile skin
Other: Delayed wound healing, hypernatremia, hypokalemia, injection site scarring, negative nitrogen balance
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Nursing Considerations for Generic Drugs
WARNING Avoid using prednisolone in patients with a history of active tuberculosis because drug can reactivate the of days!
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• Give once-daily doses in the morning to mirror body's normal cortisol secretion.
• Inspect injectable form for particulates and discoloration before administering.
• For intramuscular injection, shake suspension well before withdrawing. Keep in mind that intramuscular injections are contraindicated in patients with idiopathic thrombocytopenic purpura.
• For intraarticular injection, attach a 20G to 24G needle to empty syringe, using aseptic technique, so prescriber can remove a few drops of synovial fluid to confirm that needle is in the joint. The aspirating syringe is then exchanged with a prenisolone-filled syringe to inject drug into joint.
• Because prednisolone can produce many adverse reactions, assess patient regularly for evidence of such reactions, including heart failure and hypertension. Also monitor patient's intake, output, and daily weight.
• Monitor growth pattern in children; prednisolone may retard bone growth.
• Prolonged use may cause hypothalamic-pituitary-adrenal suppression.
WARNING Withdraw drug gradually, as ordered, if therapy lasts longer than 2 weeks. Stopping abruptly may cause acute adrenal insufficiency or, possibly, death.
• Be aware that patient may be at risk for emotional instability or psychic disturbance while taking prednisolone, especially if predisposed to them or taking high doses.
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