Protonix (Pantoprazole sodium)
Class and Category of Drug
Before you buy Protonix (Pantoprazole sodium) online, read common information about the medication.
Chemical class: Substituted benzimidazole
Therapeutic class: Antiulcer, gastric acid proton pump inhibitor
Pregnancy category: B
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Drug Indications and Dosages
Before purchase Protonix (Pantoprazole sodium) online , you must read how it works.
To treat gastroesophageal reflux disease (GERD)
Delayed-Release Tablets
Adults. 40 mg daily for up to 8 wk.
Repeated for another 4 to 8 wk if healing doesn't occur.
Intravenous Infusion
Adults. 40 mg daily infused over 2 min or 15 min for 7 to 10 days, followed by oral doses.
To maintain healing of erosive esophagitis and reduce relapse of daytime and nighttime symptoms in patients with GERD
Delayed-Release Tablets
Adults. 40 mg daily for up to 12 mo.
To treat pathological hypersecretion associated with Zollinger-Ellison syndrome or other neoplastic conditions
Intravenous Infusion
Adults. 80 mg every 12 hr infused over 2 min or 15 min; adjusted based on patient's acid output measurements up to 80 mg every 8 hr.
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Incompatibilities
Midazolam and products containing zinc may cause precipitation or discoloration.
Contraindications of Drug
Read contraindications if you want cheap Protonix (Pantoprazole sodium) online.
Hypersensitivity to pantoprazole, substituted benzimidazoles (omeprazole, lansoprazole, rabeprazole sodium), or their components
Generic Drug Interactions
Drugs
ampicillin, cyanocobalamin, digoxin, iron salts, ketoconazole: Possibly impaired absorption of these drugs
atazanavir: Significantly decreased atazanavir level
warfarin: Increased INR, PT, and bleeding risk
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Drugs Adverse Reactions
Central Nervous System: Anxiety, asthenia, confusion, dizziness, headache, hypertonia, hypokinesia, insomnia, malaise, migraine, speech disorder vertigo
Cardiovascular: Chest pain, hypercholesterolemia, hyperlipidemia
Eyes, Ears, Nose, And Throat: Anterior ischemic optic neuropathy, blurred vision, increased salivation, pharyngitis, rhinitis, sinusitis, tinnitus
Endocrine: Hyperglycemia
Gastrointestinal: Abdominal pain, atrophic gastritis, constipation, diarrhea, elevated liver function tests results, flatulence, gastroenteritis, hepatotoxicity, indigestion, nausea, pancreatitis, vomiting
Genitourinary: Elevated serum creatinine level, interstitial nephritis
Hematologic: Pancytopenia
Musculoskeletal: Arthralgia, back or neck pain, rhabdo-myolysis
Respiratory: Bronchitis, dyspnea, increased cough, upper respiratory tract infection
Skin: Erythema multiforme, rash, Stevens-Johnson syndrome, toxic epidermal necrol-ysis
Other: Anaphylaxis, angioedema, elevated creatine kinase and phosphokinase levels, flulike symptoms, generalized pain, hyperuricemia, infection, injection site reaction
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Nursing Considerations for Generic Drugs
• Ensure the continuity of gastric acid suppression during transition from oral to intravenous pantoprazole (or vice versa) because even a brief interruption of effective suppression can lead to serious complications.
• Don't give pantoprazole within 4 weeks of testing for Helicobacter pylori because antibiotics, proton pump inhibitors, and bismuth preparations suppress H. pylori and may lead to false-negative results. Drug also may cause false-positive results in urine screening tests for tetrahydro-cannabinol. Consult guidelines for pantoprazole use before testing.
• Flush intravenous line with D5W, normal saline solution, or lactated Ringer's injection before and after giving drug.
• When giving intravenous over 2 minutes, reconstitute with 10 ml of normal saline injection. Solution may be stored up to 2 hours at room temperature.
•When giving intravenous over 15 minutes, reconstitute with 10 ml normal saline injection. Then, further reconstitute with 100 ml (for GERD) or 80 ml (for pathological hypersecretion in Zollinger-Ellison syndrome) of D5W, normal saline injection, or lactated Ringer's injection. Solution may be stored up to 2 hours before further dilution and up to 22 hours before use.
• Expect to monitor prothrombin time or INR during therapy if patient takes an oral anticoagulant.
• If therapy lasts more than 3 years, patient may not be able to absorb vitamin B12 because of hypochlorhydria or achlorhydria. Treatment for cyanocobalamin deficiency may be needed.
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Pantoprazole
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
Proprietary Preparations
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