Reglan (Metoclopramide) - Anti-Acidity
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Reglan (Metoclopramide)

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Reglan (Metoclopramide)

Class and Category of Drug

Before you buy Reglan (Metoclopramide) online, read common information about the medication.

Chemical class: Benzamide

Therapeutic class: Antiemetic, upper gastrointestinal stimulant

Pregnancy category: B

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Drug Indications and Dosages

Before purchase Reglan (Metoclopramide) online , you must read how it works.

To treat diabetic gastroparesis

Oral Solution, Oral Solution Concentrate,Tablets

Adults and adolescents. 10 mg 30 min before meals and at bedtime up to q.i.d.

Intravenous or Intramuscular Injection

Adults and adolescents. 10 mg t.i.d. or q.i.d. for severe symptoms; dosage adjusted as needed.

To treat gastroesophageal reflux disease

Oral Solution, Oral Solution Concentrate,Tablets

Adults and adolescents. 10 to 15 mg 30 min before meals and at bedtime.

To prevent chemotherapy-induced vomiting

Intravenous Infusion

Adults and adolescents. 3 mg/kg before chemotherapy and then 0.5 mg/kg/hr for 8hr.

Intravenous Injection

Adults and adolescents. 1 to 2 mg/kg 30 min before chemotherapy and then repetead every 2 to 3 hr, as needed.

Children. 1 mg/kg as a single dose, repeated in 1 hr. Maximum: 2 mg/kg.

To prevent postoperative nausea and vomiting

I.M. Injection

Adults and adolescents. 10 to 20 mg near end of procedure.

Dosage Adjustment

Reduced by half if creatinine clearance is less than 40 ml/min/1.73 m2.

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Incompatibilities

Don't administer metoclopramide through same intravenous line as calcium gluconate, cephalothin sodium, chloramphenicol sodium, cisplatin, erythromycin lactobionate, furosemide, methotrexate, penicillin G potassium, or sodium bicarbonate.

Contraindications of Drug

Read contraindications if you want cheap Reglan (Metoclopramide) online.

Concurrent use of butyrophenones, phenothiazines, or other drugs that may cause extrapyramidal reactions; gastrointestinal hemorrhage, mechanical obstruction, or perforation; hypersensitivity to metoclopramide or its components; pheochromocytoma; seizure disorders

Generic Drug Interactions

Drugs

anticholinergics, opioid analgesics: Possibly decreased metoclopramide effects apomorphine: Possibly decreased antiemetic effect of apomorphine, possibly increased CNS depression

bromocriptine, pergolide: Possibly decreased therapeutic effects of these drugs cimetidine: Possibly decreased absorption and therapeutic effects of cimetidine CNS depressants: Possibly increased CNS depression

cyclosporine: Increased cyclosporine level digoxin: Decreased gastric digoxin absorption

levodopa: Possibly decreased levodopa effects

MAO inhibitors: Increased risk of severe hypertension if patient has essential hypertension

mexiletine: Possibly faster mexiletene absorption

succinylcholine: Possibly prolonged therapeutic action of succinylcholine

Activities

alcohol use: Risk of excessive sedation

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Drugs Adverse Reactions

Central Nervous System: Agitation, anxiety, depression, dizziness, drowsiness, extrapyramidal reactions (motor restlessness, parkinsonism, tardive dyskinesia), fatigue, headache, insomnia, irritability, lassitude, neuroleptic malignant syndrome, panic reaction, restlessness

Cardiovascular: atrioventricular block, fluid retention, heart failure, hypertension, hypotension, supraventricu-lar tachycardia

Eyes, Ears, Nose, And Throat: Dry mouth

Endocrine: Galactorrhea, gynecomastia

Gastrointestinal: Constipation, diarrhea, nausea

Genitourinary: Menstrual irregularities

Hematologic: Agranulocytosis

Skin: Rash

Other: Restless leg syndrome

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Nursing Considerations for Generic Drugs

• Use metoclopramide cautiously in patients with hypertension because it may increase catecholamine levels.

WARNING Watch closely for tardive dyskinesia, especially in the elderly, women, and patients with diabetes, because this serious adverse effect is often irreversible even after therapy stops. Therapy lasting longer than 12 weeks isn't recommended because risk of tardive dyskinesia increases the longer the patient takes metoclopramide. Risk also has been linked to total cumulative dose so prescriber must take this into account when setting dosage. At first sign of involuntary movements of face, tongue, or limbs, notify prescriber and expect to discontinue drug.

• Monitor patient with NADH-cytochrome b5 reductase deficiency because metoclopramide increases risk of methemoglo-binemia and sulfhemoglobinemia, and patient can't receive methylene blue.

• Assess patient for signs of intestinal obstruction, such as abnormal bowel sounds, diarrhea, nausea, and vomiting, before administering metoclopramide. Notify prescriber if you detect them.

• For intravenous use, you need not dilute doses of 10 mg or less. Give drug over 1 to 2 minutes. For doses larger than 10 mg, dilute in 50 ml normal saline solution, half-normal (0.45) saline solution, D5W, orlactated Ringer's solution and infuse over at least 15 minutes.

• Avoid rapid intravenous delivery because it may cause anxiety, restlessness, and drowsiness.

WARNING Notify prescriber if patient shows signs of toxicity, such as disorientation, drowsiness, and extrapyramidal reactions.

• Monitor patient, especially one with heart failure or cirrhosis, for possible fluid retention or volume overload due to transient increase in plasma aldosterone level.

• Monitor patient closely for neuroleptic malignant syndrome, a rare but potentially fatal disorder characterized by hyperthermia, muscle rigidity, altered level of consciousness, irregular pulse or blood pressure, tachycardia, diaphoresis, and arrhythmias.

• Store drug in a light-resistant container; discard if discolored or contains particulate.

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Metoclopramide

Preparations

International Brand Drug Names

The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.


British Pharmacopoeia, 2008 edition: Metoclopramide Injection; Metoclopramide Oral Solution; Metoclopramide Tablets;
The United States Pharmacopeia 31, 2008: Metoclopramide Injection; Metoclopramide Oral Solution; Metoclopramide Tablets.

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