Relafen (Nabumetone)
Class and Category of Drug
Before you buy Relafen (Nabumetone) online, read common information about the medication.
Chemical class: Naphthylalkanone derivative
Therapeutic class: Anti-inflammatory, antirheumatic
Pregnancy category: C (first trimester), Not rated (later trimesters)
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Drug Indications and Dosages
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To relieve symptoms of acute and chronic osteoarthritis and rheumatoid arthritis
Tablets
Adults. Initial: 1 g daily as a single dose or in divided doses b.i.d., increased to 1.5 to 2 g daily in divided doses b.i.d. Maintenance: Adjusted according to clinical response. Maximum: 2 g daily.
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Contraindications of Drug
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Angioedema, asthma, bronchospasm, nasal polyps, rhinitis, or urticaria induced by aspirin, iodides, or other NSAIDs
Generic Drug Interactions
Drugs
acetaminophen (long-term use): Increased risk of adverse renal effects
anticoagulants, thrombolytics: Increased risk of gastrointestinal bleeding
antihypertensives: Decreased antihypertensive effectiveness
beta blockers: Decreased antihypertensive effects of beta blockers
bone marrow depressants, such as aldesleukin and cisplatin: Increased risk of leucopenia and thrombocytopenia
cefamandole, cefoperazone, cefotetan, plicamycin, valproic acid: Increased risk of hypoprothrombinemia and bleeding
colchicine, other nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates:Increased gastrointestinal irritability and bleeding
cyclosporine, gold compounds, nephrotoxic drugs: Increased risk of nephrotoxicity
digoxin: Increased blood digoxin level and risk of digitalis toxicity
diuretics: Decreased diuretic effectiveness
glucocorticoids, potassium supplements:Increased gastrointestinal irritability and bleeding
insulin, oral antidiabetic drugs: Increased effects of these drugs; risk of hypoglycemia
lithium: Increased risk of lithium toxicity
methotrexate: Increased risk of methotrexate toxicity
probenecid: Increased risk of nabumetone toxicity
Activities
alcohol use: Increased gastrointestinal irritability and bleeding
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Drugs Adverse Reactions
Central Nervous System: Drowsiness, fatigue, fever, headache, nervousness, seizures, stroke, vertigo
Cardiovascular: Edema, hypertension, MI, tachycardia
Eyes, Ears, Nose, And Throat: Dry mouth, pharyngitis, stomatitis, tinnitus
Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, diverticulitis, dyspepsia, dysphagia, esophagitis, flatulence, gastritis, gastroenteritis, gastroesophageal reflux disease, gastrointestinal bleeding and ulceration, hepatic dysfunction, indigestion, jaundice, melena, nausea, perforation of stomach or intestines, stomatitis, vomiting
Genitourinary: Albuminuria, azotemia, interstitial nephritis, nephrotic syndrome
Hematologic: Agranulocytosis, anemia, eosinophilia, granulocytopenia, hemolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia
Musculoskeletal: Muscle spasms, myalgia
Respiratory: Asthma, pneumonitis, respiratory depression
Skin: Alopecia, erythema multiforme, photosensitivity, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis
Other: Anaphylaxis, angioedema
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Nursing Considerations for Generic Drugs
• Use nabumetone with extreme caution in patients with a history of ulcer disease or GI bleeding because NSAIDs such as nabumetone increase risk of gastrointestinal bleeding and ulceration. Expect to use nabumetone for shortest time possible in these patients.
• Be aware that serious gastrointestinal tract ulceration, bleeding, and perforation may occur without warning symptoms. Elderly patients are at greater risk. To minimize risk, give drug with food. If gastrointestinal distress occurs, withhold drug and notify prescriber immediately.
• Use nabumetone cautiously in patients with hypertension, and monitor blood pressure closely throughout therapy. Drug may cause hypertension or worsen it.
WARNING Monitor patient closely for thrombotic events, including MI and stroke, because NSAIDs increase the risk.
• Monitor patient — especially if elderly or receiving long-term nabumetone therapy — for less common but serious adverse gastrointestinal reactions, including anorexia, constipation, diverticulitis, dysphagia, esophagitis, gastritis, gastroenteritis, gastroesophageal reflux disease, hemorrhoids, hiatal hernia, melena, stomatitis, and vomiting.
• Monitor liver function test results because, rarely, elevations may progress to severe hepatic reactions, including fatal hepatitis, liver necrosis, and hepatic failure.
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Nabumetone
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Nabumetone Oral Suspension; Nabumetone Tablets;
The United States Pharmacopeia 31, 2008: Nabumetone Tablets.
Proprietary Preparations
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