Seroquel (Quetiapine)
Class and Category of Drug
Before you buy Seroquel (Quetiapine) online, read common information about the medication.
Chemical class: Dibenzothiazepine derivative
Therapeutic class: Antipsychotic
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Seroquel (Quetiapine) online , you must read how it works.
To treat schizophrenia
Tablets
Adults. Initial: 25 mg b.i.d. on day 1. Increased by 25 to 50 b.i.d. or t.i.d. on days 2 and 3. Usual:: 300 to 400 mg daily by day 4, in divided doses b.i.d. or t.i.d. Increased every 2 days in increments of 25 to 50 mg b.i.d., as needed. Maximum: 800 mg daily.
E.R. Tablets
Adults. Initial: 300 mg once daily in evening. Dosage increased daily in increments up to 300 mg, as needed. Maximum: 800 mg daily.
To manage psychotic disorders other than schizophrenia
Tablets
Adults. Initial: 25 mg b.i.d. on day 1. Dosage increased by 25 to 50 mg b.i.d. or t.i.d. on days 2 and 3. Usual:: 300 to 400 mg daily by day 4, in divided doses b.i.d. or t.i.d. Dosage increased every 2 days in increments of 25 to 50 mg b.i.d., as needed. Maximum: 800 mg daily.
To treat depressive episodes in bipolar disorder
Tablets
Adults. Initial: On day one, 50 mg once at bedtime; day two, 100 mg once at bedtime; day three, 200 mg once at bedtime; day four, 300 mg once at bedtime. Maintenance: 300 mg once daily at bedtime.
E.R.Tablets
Adults. Initial: 50 mg once daily in evening on day 1, followed by 100 mg once daily in evening on day 2, 200 mg once daily in evening on day 3, and 300 mg once daily in evening on day 4 and thereafter.
As adjunct therapy with antidepressants to treat major depressive disorder
E.R.Tablets
Adults. Initial: 50 mg once daily in evening, increased to 150 mg once daily in evening on day 3. Maximum: 300 mg daily in evening.
To treat acute manic episodes in bipolar disorder
Tablets
Adults. 50 mg b.i.d., increased to 200 mg b.i.d on day 4 (in increments no greater than 100 mg daily) and then further increased to 400 mg b.i.d. on day 6 (in increments no greater than 200 mg daily), as needed.
To treat acute manic episodes in bipolar I disorder as monotherapy; as adjunct with lithium or divalproex to treat acute manic episodes in bipolar disorder
E.R. Tablets
Adults. Initial: 300 mg once daily in evening on day 1, followed by 600 mg once daily in evening on day 2 and 200 to 400 mg b.i.d. on day 3 and there after. Maintenance: 200 to 400 mg b.i.d.
Dosage Adjustment For elderly patients and patients with hepatic impairment, initial dosage no higher than 50 mg once daily and increased in increments of 50 mg/day depending on response and tolerance.
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Contraindications of Drug
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Hypersensitivity to quetiapine or its components
Generic Drug Interactions
Drugs
antihypertensives: Possibly enhanced antihy-pertensive effects of these drugs cimetidine, erythromycin, fluconazole, itra-conazole, ketoconazole: Decreased clearance and possibly increased effects of quetiapine CNS depressants: Possibly increased CNS depression
lorazepam: Possibly increased effects of lorazepam
phenytoin, thioridazine: Increased clearance and possibly decreased effectiveness of quetiapine
Activities
alcohol use: Possibly enhanced CNS depression
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Drugs Adverse Reactions
Central Nervous System: Depression, dizziness, drowsiness, dystonia, extrapyramidal reactions, hyper-tonia, lethargy, restless leg syndrome, somnolence, suicidal ideation, tardive dyskine-sia
Cardiovascular: Cardiomyopathy, hypercholesterolemia,
myocarditis, orthostatic hypotension, palpitations
Eyes, Ears, Nose, And Throat: Dry mouth, nasal congestion, pharyngitis, rhinitis
Endocrine: Hyperglycemia, syndrome of inappropriate ADH secretion
Gastrointestinal: Anorexia, constipation, indigestion
Hematologic: Agranulocytosis, leukopenia, neutropenia
Musculoskeletal: Dysarthria, muscle weakness, rhabdomyolysis
Respiratory: Cough, dyspnea
Skin: Diaphoresis, Stevens-Johnson syndrome
Other: Anaphylaxis, flulike symptoms, weight gain
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Nursing Considerations for Generic Drugs
WARNING Quetiapine shouldn't be used for elderly patients with dementia-related psychosis because drug increases the risk of death in these patients.
• Monitor patients (particularly young adults) closely for suicidal tendencies, especially when therapy starts or dosage changes, because depression may worsen temporarily during these times.
WARNING Monitor patient taking quetiapine for predisposing factors for neuroleptic malignant syndrome, such as heat stress, physical exhaustion, dehydration, and organic brain disease. Neuroleptic malignant syndrome includes hyperpyrexia, muscle rigidity, altered mental status, and autonomic instability (which may include irregular pulse or blood pressure, tachycardia, diaphoresis, and arrhythmias).
• Monitor patient for signs of tardive dyski-nesia, a potentially irreversible complication characterized by involuntary, dyskinetic movements of tongue, mouth, jaw, eyelids, or face. Notify prescriber if such signs develop because quetiapine therapy may need to be stopped.
• Monitor patient for orthostatic hypotension, especially during initial dosage titra-tion period. Be prepared to correct underlying conditions, such as hypovolemia and dehydration, before starting quetiapine therapy, as prescribed.
• Monitor patient for prolonged abnormal muscle contractions, especially during the first few days of quetiapine therapy, in male patients, and in younger patients.
• Assess patient for hypothyroidism because drug can cause dose-dependent decreases in total and free thyroxine (T4) levels.
• Monitor laboratory results during first 3 weeks of therapy for transient elevations in hepatic enzyme levels. Notify prescriber if they persist or worsen.
• Monitor patient's blood glucose and lipid levels routinely, as ordered, because drug increases the risk of hyperglycemia and hypercholesterolemia.
• Check CBC often during the first few months of therapy, as ordered, in patients with a low white blood cell count or a history of drug-induced hematologic problems. If counts drop or patient develops a fever or other signs of infection, notify prescriber and expect to discontinue drug and provide supportive care.
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Quetiapine
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
Proprietary Preparations
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