Synthroid (Levothyroxine)
Class and Category of Drug
Before you buy Synthroid (Levothyroxine) online, read common information about the medication.
Chemical class: Synthetic thyroxine (T4)
Therapeutic class: Thyroid hormone replacement
Pregnancy category: A
P.O. administration is tolerated. Children. 75% of usual P.O. dose daily until therapeutic blood level is reached and P.O. administration is tolerated.
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Contraindications of Drug
Before purchase Synthroid (Levothyroxine) online , you must read how it works.
Acute MI (unless caused or complicated by hyperthyroidism), hypersensitivity to levothyroxine or its components, uncorrected adrenal insufficiency, untreated thyrotoxicosis
Generic Drug Interactions
Drugs
adrenocorticoids: Possibly adrenocorticoid dosage adjustments as thyroid status changes
aluminum- and magnesium-containing antacids, bile acid sequestrants, calcium carbonate, cation exchange resins, cholestyramine, colestipol, ferrous sulfate, kayexalate, orlistat, sucralfate: Possibly reduced effects of levothyroxine
amiodarone, iodide: Possibly hyperthyroidism beta blockers: Possibly impaired action of beta blockers and decreased conversion of T4 to triiodothyronine (T3)
cholestyramine, colestipol: Delayed or inhibited levothyroxine absorption
digoxin: Reduced digoxin effects
estrogen, phenylbutazone, phenytoin: Reduced binding of levothyroxine to protein, possibly requiring increased levothyroxine dosage
insulin, oral antidiabetic drugs: Possibly uncontrolled diabetes mellitus, requiring increased dosage of insulin or oral antidiabetic drug
ketamine: Possibly hypertension and tachycardia
maprotiline: Increased risk of arrhythmias oral anticoagulants: Altered anticoagulant activity, possibly need for anticoagulant dosage adjustment
selective serotonin reuptake inhibitors, tricyclic and tetracyclic antidepressants: Increased therapeutic and toxic effects of both drugs
sympathomimetics: Increased risk of coronary insufficiency in patients with coronary artery disease
theophylline: Decreased theophylline clearance
Foods
dietary fiber, soybean flour (infant formula), walnuts: Possibly decreased absorption of levothyroxine from gastrointestinal tract
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Drugs Adverse Reactions
Central Nervous System: Fatigue, headache, insomnia, somnolence
Endocrine: Hyperthyroidism (with overdose)
Gastrointestinal: Dysphagia
Musculoskeletal: Muscle weakness, myalgia, slipped capital femoral epiphysis
Skin: Alopecia (transient), rash, urticaria
Other: Weight gain
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Nursing Considerations for Generic Drugs
Administer levothyroxine tablets as a single daily dose 30 to 60 minutes before breakfast. If patient has difficulty swallowing, crush tablet and suspend in a small amount of water or food.
To prevent decreased drug absorption, give oral levothyroxine at least 4 hours before or after aluminum- or magnesium-containing antacids, bile acid sequestrants, calcium carbonate, cation exchange resins, cholestyramine, colestipol, ferrous sulfate, kayexalate, or sucralfate.
Expect to give drug intravenous or intramuscular if patient can't take tablets. Be aware that drug shouldn't be given subcutaneously
For intravenous use, reconstitute drug by adding 5 ml of normal saline solution.
Monitor prothrombin time of patient who is receiving anticoagulants; she may require a dosage adjustment.
Monitor blood glucose level of diabetic patient. Prescriber may reduce antidiabetic drug dosage as thyroid hormone level enters therapeutic range.
Expect patient to undergo thyroid function tests regularly during levothyroxine therapy.
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Levothyroxine
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Levothyroxine Tablets;
The United States Pharmacopeia 31, 2008: Levothyroxine Sodium Tablets; Liotrix Tablets.
Proprietary Preparations
Argentina: Euthyrox; Juno; T4;
Australia: Eutroxsig; Oroxine;
Austria: Euthyrox; Neothyron; Thyrex;
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Belgium: Elthyrone; Euthyrox; Thyrax;
Brazil: Euthyrox; Puran T4; Synthroid; Tetroid; Tiroidin;
Canada: Eltroxin; Euthyrox; Synthroid;
The pharmaceutical companies our pharmacies buy from follow strict WHO standards for GMP.
Chile: Esaldox; Eutirox;
Czech Republic: Eltroxin; Euthyrox; Letrox; Thyrax;
Denmark: Eltroxin;
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France: Levothyrox;
Germany: Berlthyrox; Eferox; Euthyrox; LThyrox; Lixin; Thevier ;
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Greece: Levothroid; T-4; Thyro-4; Thyrohormone;
Hong Kong: Eltroxin;
Hungary: Euthyrox; Letrox;
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India: Eltroxin;
Indonesia: Euthyrox; Thyrax;
Ireland: Eltroxin; Israel: Eltroxin;
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Italy: Eutirox; Tiracrin; Tirosint;
Japan: Thyradin-S;
Malaysia: Oroxine;
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Mexico: Abutiroi; Cynocuatro; Daltroid; Eutirox; Sintrocid; Tiroidine;
Netherlands or Holland: Eltroxin; Euthyrox; Thyrax;
Norway: Levaxin;
New Zealand: Eltroxin;
Philippines: Eltroxin; Euthyrox; Thyrax; Thyrohex;
Poland: Eferox; Eltroxin; Euthyrox; Letrox;
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Portugal: Eutirox; Letequatro; Letter; Thyrax;
Russia: Bagothyrox (Баготирокс); Euthyrox (Эутирокс);
South Africa:
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France: Eltroxin;
Singapore: Eltroxin; Euthyrox; Oroxine;
Spain: Dexnon; Eutirox; Levothroid;
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Sweden: Euthyrox; Levaxin;
Switzerland: Eltroxine; Euthyrox;
Thailand: Elthyro; Eltroxin; Euthyrox; Pondtroxin; Thyrosit;
Turkey: Levotiron; Tefor;
UK or Britain: Eltroxin; Evotrox;
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US or USA: Levothroid; Levoxyl; Novothyrox; Synthroid; Unithroid;
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Venezuela: Euthyrox; Thyrax.
Multi-ingredient
Argentina: Eutroid; Levotrin;
Austria: Combithyrex; Jodthyrox; Novothyral; Prothyrid;
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Belgium: Novothyral;
Brazil: Tyroplus;
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Chile: Novothyral;
Czech Republic: Jodthyrox; Novothyral; Thyreotom;
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France: Euthyral;
Germany: Eferox Jod; Jodthyrox; L-Thyrox Jod; Novothyral; Prothyrid; Thyreocomb N; Thyreotom; Thyronajod;
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Greece: Dithyron;
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Italy: Dermocinetic; Somatoline; Tiroide Amsa;
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Mexico: Cynoplus; Novotiral; Proloid S;
Poland: Jodthyrox; Novothyral;
Russia: Jodthyrox (Йодтирокс); Novothyral (Новотирал); Thyreocomb (Тиреокомб); Thyreotom (Тиреотом);
South Africa:
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France: Diotroxin;
Switzerland: Novothyral;
Turkey: Bitiron;
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US or USA: Thyrolar.
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