Trandate (Labetalol)
Class and Category of Drug
Before you buy Trandate (Labetalol) online, read common information about the medication.
Chemical class: Benzamine derivative
Therapeutic class: Antihypertensive
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Trandate (Labetalol) online , you must read how it works.
To manage hypertension
Tablets
Adults. Initial: 100 mg b.i.d., increased by 100 mg b.i.d. as needed and tolerated every 2 to 3 days. Maintenance: 200 to 400 mg b.i.d. For severe hypertension, 1.2 to 2.4 g daily in divided doses b.i.d. or t.i.d.
To manage severe hypertension and treat hypertensive emergencies
Intravenous Infusion
Adults. 200 mg diluted in 160 ml of D5W and infused at 2 mg/min until desired response occurs.
Intravenous Injection
Adults. 20 mg given over 2 min; additional doses given in increments of 40 to 80 mg every 10 min as indicated until desired response occurs. Maximum: 300 mg.
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Incompatibilities
Don't dilute labetalol in sodium bicarbonate solution or give through same intravenous line as alkaline drugs, such as furosemide; doing so may cause white precipitate to form.
Contraindications of Drug
Read contraindications if you want cheap Trandate (Labetalol) online.
Asthma, cardiogenic shock, heart failure, hypersensitivity to labetalol or its components, second- or third-degree heart block, severe bradycardia
Generic Drug Interactions
Drugs
allergen immunotherapy, allergenic extracts for skin testing: Increased risk of serious systemic reaction or anaphylaxis
beta blockers, digoxin: Increased risk of bradycardia
calcium channel blockers, clonidine, diazoxide, guanabenz, reserpine: Possibly hypotension
cimetidine: Possibly increased labetalol effects
estrogens, NSAIDs: Possibly reduced antihypertensive effect of labetalol
general anesthetics: Increased risk of hypotension and myocardial depression
insulin, oral antidiabetic drugs: Increased risk of hyperglycemia
nitroglycerin: Possibly hypertension
phenoxybenzamine, phentolamine: Possibly additive alpha1-blocking effects
sympathomimetics with alpha- and beta-adrenergic effects (such as pseudoephedrine): Possibly hypertension, excessive bradycardia, or heart block
xanthines (aminophylline and theophylline): Possibly decreased therapeutic effects of both drugs
Foods
all food: Increased blood labetalol level
Activities
alcohol use: Increased labetalol effects
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Drugs Adverse Reactions
Central Nervous System: Anxiety, confusion, depression, dizziness, drowsiness, fatigue, paresthesia, syncope, vertigo, weakness, yawning
Cardiovascular: Bradycardia, chest pain, edema, heart block, heart failure, hypotension, orthostatic hypotension, ventricular arrhythmias
Eyes, Ears, Nose, And Throat: Nasal congestion, taste perversion
Gastrointestinal: Elevated liver function test results, hepatic necrosis, hepatitis, indigestion, nausea, vomiting
Genitourinary: Ejaculation failure, impotence
Respiratory: Dyspnea, wheezing
Skin: Jaundice, pruritus, rash, scalp tingling
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Nursing Considerations for Generic Drugs
• During intravenous labetalol use, monitor blood pressure according to facility policy, usually every 5 minutes for 30 minutes, then every 30 minutes for 2 hours, and then every hour for 6 hours.
• Keep patient in supine position for 3 hours after intravenous administration.
WARNING Be aware that labetalol masks common signs of shock.
• Monitor blood glucose level in diabetic patient because labetalol may conceal symptoms of hypoglycemia.
• Be aware that stopping labetalol tablets abruptly after long-term therapy could result in angina, MI, or ventricular arrhythmias. Expect to taper dosage over 2 weeks while monitoring response.
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Labetalol
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Labetalol Injection; Labetalol Tablets;
The United States Pharmacopeia 31, 2008: Labetalol Hydrochloride Injection; Labetalol Hydrochloride Oral Suspension; Labetalol Hydrochloride Tablets.
Proprietary Preparations
Argentina: Biascor;
Australia: Presolol; Trandate;
Austria: Trandate;
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Belgium: Trandate;
Canada: Trandate;
The pharmaceutical companies our pharmacies buy from follow strict WHO standards for GMP.
Chile: Trandate;
Czech Republic: Coreton; Trandate;
Denmark: Trandate;
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Finland: Albetol;
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France: Trandate;
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Greece: Trandate;
Hong Kong: Trandate;
Ireland: Trandate; Israel: Trandate;
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Italy: Ipolab; Trandate;
Malaysia: Tolbetol; Trandate;
Netherlands or Holland: Trandate;
Norway: Trandate;
New Zealand: Hybloc; Trandate;
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Venezuela: Trandate.
Multi-ingredient
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Italy: Trandiur.
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