Vantin (Cefpodoxime proxetil)
Class and Category of Drug
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Chemical class: Third-generation cephalosporin, 7-aminocephalosporanic acid
Therapeutic class: Antibiotic
Pregnancy category: B
Drug Indications and Dosages
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To treat acute community-acquired pneumonia caused by Haemophilus influenzae or Streptococcus pneumoniae
Oral Suspension, Tablets
Adults and adolescents over age 13.200 mg every 12 hr for 14 days.
To treat acute bacterial exacerbation of chronic bronchitis caused by H. influenzae, Moraxella catarrhalis, or S. pneumoniae
Tablets
Adults and adolescents over age 13. 200 mg every 12 hr for 10 days.
To treat uncomplicated gonorrhea in men and women and rectal gonococcal infections in women caused by Neisseria gonorrhoeae
Oral Suspension, Tablets
Adults. 200 mg as a single dose.
To treat uncomplicated Urinary tract infection caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Staphylococcus saprophyticus
Oral Suspension, Tablets
Adults. 100 mg every 12 hr for 7 days.
To treat skin and soft-tissue infections caused by Staphylococcus aureus or Staphylococcus pyogenes
Oral Suspension, Tablets
Adults and adolescents over age 13.400 mg every 12 hr for 7 to 14 days.
To treat acute otitis media caused by H. influenzae, M. catarrhalis, or S. pneumoniae
Oral Suspension, Tablets
Children ages 5 months through 12 years. 5 mg/kg every 12 hr (Maximum: 200 mg/dose) or 10 mg/kg every 24 hr (Maximum:400 mg/dose) for 10 days.
To treat pharyngitis and tonsillitis caused by S. pyogenes
Oral Suspension, Tablets
Adults and adolescents over age 13.100 mg every 12 hr for 5 to 10 days.
Children ages 2 months through 12 years. 5 mg/kg every 12 hr for 5 to 10 days. Maximum: 100 mg/dose.
Dosage Adjustment Dosing interval increased to 24 hr in patients with creatinine clearance less than 30 ml/min/1.73 m2.
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Contraindications of Drug
Read contraindications if you want cheap Vantin (Cefpodoxime proxetil) online.
Hypersensitivity to cephalosporins or thei components
Generic Drug Interactions
Drugs
aminoglycosides, loop diuretics: Increased risk of nephrotoxicity
antacids, H2-receptor antagonists: Reduced bio availability and blood level of cefpodoxime
oral anticholinergics: Delayed peak blood level of cefpodoxime
probenecid: Possibly increased and prolonged blood cefpodoxime level
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Drugs Adverse Reactions
Central Nervous System: Chills, fever, headache, seizures
Cardiovascular: Edema
Eyes, Ears, Nose, And Throat: Hearing loss
Gastrointestinal: Abdominal cramps, diarrhea, elevated liver function test results, hepatic failure, hepatomegaly, nausea, oral candidiasis, pseudomembranous colitis, vomiting
Genitourinary: Elevated BUN level, nephrotoxicity, renal failure, vaginal candidiasis
Hematologic: Eosinophilia, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia, unusual bleeding
Musculoskeletal: Arthralgia
Respiratory: Dyspnea
Skin: Ecchymosis, erythema, erythema multiforme, pruritus, rash, Stevens-Johnson syndrome
Other: Anaphylaxis, superinfection
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Nursing Considerations for Generic Drugs
Use cefpodoxime cautiously in patients who have impaired renal function or are receiving potent diuretics. Also use drug cautiously in patients hypersensitive to penicillin because cross-sensitivity has occurred in about 10% of such patients.
If possible, obtain culture and sensitivity test results, as ordered, before giving cefpodoxime.
Assess patient's bowel pattern daily; severe diarrhea may indicate pseudomembranous colitis.
Be aware that an allergic reaction may occur a few days after therapy starts.
Patient Teaching of Drugs
Urge patient to complete the prescribed course of therapy.
Tell patient to take tablets with food to enhance absorption.
Advise patient to refrigerate oral suspension and discard after 14 days. Instruct patient to shake oral suspension bottle well before pouring dose and to use a calibrated liquid-measuring device to ensure accurate doses. Inform patient that yogurt and buttermilk can help maintain intestinal flora and decrease diarrhea.
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Cefpodoxime
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
The United States Pharmacopeia 31, 2008: Cefpodoxime Proxetil for Oral Suspension; Cefpodoxime Proxetil Tablets.
Proprietary Preparations
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US or USA: Vantin.
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