Vasotec (Enalapril) - Blood Pressure/Cholesterol
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Top » Catalog » Blood Pressure/Cholesterol » Vasotec (Enalapril)


Vasotec (Enalapril)

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Vasotec (Enalapril)

Class and Category of Drug

Before you buy Vasotec (Enalapril) online, read common information about the medication.

Chemical class: Dicarbocyl-containing ACE inhibitor

Therapeutic class: Antihypertensive

Pregnancy category: C (first trimester), D (later trimesters)

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Drug Indications and Dosages

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To control hypertension

Tablets

Adults. Initial: 5 mg daily, increased after 1 to 2 wk, as needed. Maintenance: 10 to 40 mg once daily or in divided doses b.i.d.

Children. 0.08 mg/kg daily, titrated according to blood pressure response up to 5 mg daily. Maximum: 0.58 mg/kg/dose or 40 mg/dose.

Intravenous Injection

Adults. 1.25 mg every 6 hr.

Dosage Adjustment Initial dose 2.5 mg P.O. or 0.625 mg intravenous for patients who have sodium and water depletion from diuretic therapy, are receiving diuretics, or have a creatinine clearance below 30 ml/min/ 1.73 m2. If response to intravenous dose is inadequate after 1 hr, intravenous dose of 0.625 mg is repeated and therapy continued at 1.25 mg every 6 hr.

To treat heart failure

Tablets

Adults. Initial: 2.5 mg once or twice daily, increased after 1 to 2 wk, as needed. Maintenance: 5 to 40 mg once daily or in divided doses b.i.d.

To treat asymptomatic left ventricular dysfunction

Tablets

Adults. Initial: 2.5 mg b.i.d., increased to 20 mg daily in divided doses.

Dosage Adjustment Initial dosage reduced to 2.5 mg daily and, if possible, diuretic dosage reduced in patients who have a serum sodium level below 130 mEq/L or a serum creatinine level above 1.6 mg/dl.

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Contraindications of Drug

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History of angioedema from previous ACE inhibitor; hypersensitivity to enalapril, enalaprilat, or their components

Generic Drug Interactions

Drugs

allopurinol, bone marrow depressants (such as amphotericin B and methotrexate), procainamide, systemic corticosteroids: Possibly increased risk of fatal neutropenia or agranulocytosis

cyclosporine, potassium-sparing diuretics, potassium supplements: Increased risk of hyperkalemia

diuretics, other antihypertensives: Additive hypotensive effects

lithium: Increased blood lithium level and lithium toxicity

NSAIDs: Possibly reduced antihypertensive effects of enalapril and enalaprilat

sodium aurothiomalate: Increased risk of nitritoid reactions, such as facial flushing, nausea, vomiting, and hypotension

sympathomimetics: Possibly reduced therapeutic effects of enalapril and enalaprilat

Foods

potassium-containing salt substitutes: Increased risk of hyperkalemia

Activities

alcohol use: Possibly additive hypotensive effect

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Drugs Adverse Reactions

Central Nervous System: Ataxia, confusion, depression, dizziness, dream disturbances, fatigue, headache, insomnia, nervousness, peripheral neuropathy, somnolence, stroke, syncope, vertigo, weakness

Cardiovascular: Angina, arrhythmias, cardiac arrest, hypotension, MI, orthostatic hypotension, palpitations, pulmonary embolism and infarction, Raynaud's phenomenon

Eyes, Ears, Nose, And Throat: Blurred vision, conjunctivitis, dry eyes and mouth, glossitis, hoarseness, lacrimation, loss of smell, pharyngitis, rhinorrhea, stomatitis, taste perversion, tinnitus

Endocrine: Gynecomastia

Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, hepatic failure, hepatitis, ileus, indigestion, melena, nausea, pancreatitis, vomiting

Genitourinary: Flank pain, impotence, oliguria, renal failure, Urinary tract infection

Musculoskeletal: Muscle spasms

Respiratory: Asthma, bronchitis, bronchospasm, cough, dyspnea, pneumonia, pulmonary edema, pulmonary infiltrates, upper respiratory tract infection

Skin: Alopecia, diaphoresis, erythema multiforme, exfoliative dermatitis, flushing, pemphigus, photosensitivity, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria

Other: Anaphylaxis, angioedema, herpes zoster, hyperkalemia

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