Zanaflex (Tizanidine)
Class and Category of Drug
Before you buy Zanaflex (Tizanidine) online, read common information about the medication.
Chemical class: Imidazoline
Therapeutic class: Antispasmodic
Pregnancy category: C
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Drug Indications and Dosages
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To manage acute and intermittent increases of muscle tone with spasticity
Tablets
Adults. 4 mg every 6 to 8 hr, p.r.n., increased gradually by 2 to 4 mg/dose, as needed and as prescribed. Maximum: 36 mg daily or 3 doses daily.
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Contraindications of Drug
Read contraindications if you want cheap Zanaflex (Tizanidine) online.
Hypersensitivity to tizanidine or its components, use with ciprofloxacin or fluvoxamine
Generic Drug Interactions
Drugs
acetaminophen: Delayed peak effects of acetaminophen
alpha2-adrenergic agonists: Possibly significant hypotension
antihypertensives: Additive hypotensive effects
CYP1A2 inhibitors (such as acyclovir, amiodarone, cimetidine, famotidine, mexiletine, propafenone, ticlopidine, verapamil, zileuton), fluroquinolones (including ciprofloxacin, fluvoxamine): Possibly increased plasma tizanidine level; increased risk of hypotension and sedation
oral contraceptives: Decreased tizanidine clearance
rofecoxib: Possibly increased adverse reactions
Activities
alcohol use: Increased adverse effects of tizanidine, additive CNS depression
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Drugs Adverse Reactions
Central Nervous System: Anxiety, delusions, drowsiness, dyskinesia, fatigue, fever, hallucinations, slurred speech
Cardiovascular: Orthostatic hypotension
Eyes, Ears, Nose, And Throat: Dry mouth, pharyngitis, rhinitis
Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, dyspepsia, elevated liver function test results, hepatic failure, hepatomegaly, nausea, vomiting
Genitourinary: Urinary frequency, urinary tract infection
Musculoskeletal: Back pain, muscle weakness, myasthenia
Skin: Diaphoresis, jaundice, rash, ulceration
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Nursing Considerations for Generic Drugs
• Be aware that extreme caution is required if tizanidine is prescribed for a patient with hepatic impairment because the drug is extensively metabolized in the liver.
• Monitor hepatic and renal function for first 6 months and periodically thereafter.
• Expect prolonged drug use to inhibit saliva.
• Be aware that tizanidine should be stopped slowly to prevent withdrawal and rebound hypertension, tachycardia, and hypertonia.
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Tizanidine
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
The United States Pharmacopeia 31, 2008: Tizanidine Tablets.
Proprietary Preparations
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