Zantac (Ranitidine)
Class and Category of Drug
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Chemical class: Aminoallcyl-substituted furan derivative
Therapeutic class: Antiulcer agent, gastric acid secretion inhibitor
Pregnancy category: B
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Drug Indications and Dosages
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To prevent duodenal and gastric ulcers
Advise patient to stop taking ramipril and inform prescriber immediately if she experiences swelling of the face, eyes, lips, or tongue or has difficulty breathing. Explain that drug may cause dizziness and light-headedness, especially during first few days of therapy. Instruct patient to notify prescriber immediately if she faints. Inform female patient of childbearing age of the risks of taking ramipril during pregnancy. Caution patient to use effective contraception and to report known or suspected pregnancy immediately. Urge patient to tell providers that she takes ramipril before having surgery or anesthesia.
Tell patient to ask prescriber before using supplements or salt substitutes that contain potassium.
Capsules, Effervescent Granules, Effervescent Tablets, Syrup, Tablets
Adults and adolescents. 150 mg at bedtime.
To provide short-term treatment of active duodenal and benign gastric ulcers
Capsules, Effervescent Granules, Effervescent Tablets, Syrup, Tablets
Adults and adolescents. 150 mg b.i.d. for gastric ulcers; 150 mg b.i.d. or 300 mg at bedtime for duodenal ulcers. Children ages 1 month to 16 years. 2 to 4 mg/kg b.i.d. up to 300 mg daily. Maintenance: 2 to 4 mg/kg daily up to 150 mg daily.
Continuous Intravenous Infusion
Adults and adolescents. 6.25 mg/hr. Maximum: 400 mg daily.
Intermittent Intravenous Infusion
Adults and adolescents. 50 mg diluted to total volume of 100 ml and infused over 15 to 20 min every 6 to 8 hr. Maximum: 400 mg daily.
Children. 2 to 4 mg/kg daily diluted to a suitable volume and infused over 15 to 20 min.
Intravenous Injection
Adults and adolescents. 50 mg diluted to total volume of 20 ml and injected slowly over no less than 5 min every 6 to 8 hr. Maximum: 400 mg daily.
I.M. Injection
Adults and adolescents. 50 mg every 6 to 8 hr. Maximum: 400 mg daily.
To treat acute gastroesophageal reflux disease
Capsules, Effervescent Granules, Effervescent Tablets, Syrup, Tablets
Adults and adolescents. 150 mg b.i.d.
Effervescent Tablets
Children ages 1 month to 16 years. 2.5 to 5 mg/kg b.i.d.
Intermittent Intravenous Infusion
Children. 2 to 8 mg/kg diluted to suitable volume and infused over 15 to 20 min t.i.d.
To treat erosive esophagitis
Capsules, Effervescent Granules, Effervescent Tablets, Syrup, Tablets
Adults and adolescents. 150 mg q.i.d.
Effervescent Tablets
Children ages 1 month to 16 years. 2.5 to 5 mg/kg b.i.d.
To treat hypersecretory gastrointestinal conditions, such as Zollinger-Ellison syndrome, systemic mastocytosis, and multiple endocrine adenoma syndrome
Capsules, Effervescent Granules, Effervescent Tablets, Syrup, Tablets
Adults and adolescents. Initial: 150 mg b.i.d., adjusted as needed. Maximum: 6 g daily in divided doses.
Continuous Intravenous Infusion
Adults and adolescents. Initial: 1 mg/kg/hr, increased by 0.5 mg/kg/hr up to 2.5 mg/kg/ hr. Maximum: 400 mg daily.
Intermittent Intravenous Infusion
Adults. 50 mg diluted to total volume of 100 ml and infused over 15 to 20 min every 6 to 8 hr. Maximum: 400 mg daily.
Intravenous Injection
Adults and adolescents. 50 mg diluted to total of 20 ml and injected slowly over at least 5 min every 6 to 8 hr. Maximum: 400 mg daily.
Intramuscular Injection
Adults. 50 mg every 6 to 8 hr.
To prevent acid indigestion, heartburn, and sour stomach caused by eating certain foods or drinking certain beverages
Tablets
Adults and adolescents. 75 mg 30 to 60 min before food or beverages expected to cause symptoms. Maximum: 150 mg daily over no more than 2 continuous wk.
To treat acid indigestion, heartburn, and sour stomach
Tablets
Adults and adolescents. 75 mg when symptoms start; repeated once within 24 hr, if needed.
Dosage Adjustment For patients whose creatinine clearance is less than 50 ml/min/ 1.73 m2, 150 mg P.O. every 24 hr with dosage interval increased thereafter to every 12 hr, as needed. Or 50 mg intravenous every 18 to 24 hr with dosage interval increased to every 12 hr, as needed. Dosage reduction may also be necessary for patients with hepatic dysfunction.
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Contraindications of Drug
Read contraindications if you want cheap Zantac (Ranitidine) online.
Acute porphyria, hypersensitivity to ranitidine or its components
Generic Drug Interactions
Drugs
antacids: Decreased ranitidine absorption atazanavir, delavirdine, diazepam, gefitinib, itraconazole, ketoconazole, sucralfate: Decreased absorption of these drugs bone marrow depressants: Increased risk of neutropenia or other blood dyscrasias glipizide, glyburide, metoprolol, midazolam, nifedipine, phenytoin, theophylline, triazolam: Increased effects of these drugs, possibly leading to toxic reactions procainamide: Possibly increased risk of procainamide toxicity
warfarin: Possibly altered prothrombin time
Activities
alcohol use: Increased blood alcohol level (with oral ranitidine)
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Drugs Adverse Reactions
Central Nervous System: Dizziness, drowsiness, fever, headache, insomnia
Cardiovascular: Vasculitis
Gastrointestinal: Abdominal distress, constipation, diarrhea, nausea, vomiting
Genitourinary: Acute interstitial nephritis, impotence
Musculoskeletal: Arthralgia, myalgia
Respiratory: Bronchospasm
Skin: Alopecia, erythema multiforme, rash
Other: Anaphylaxis, angioedema
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Nursing Considerations for Generic Drugs
• Be aware that ranitidine must be diluted for intravenous use if not using premixed solution. For intravenous injection, dilute to total of 20 ml with normal saline solution, D5W, D10W, lactated Ringer's solution, or 5% sodium bicarbonate. For intravenous infusion, dilute to total volume of 100 ml of same solutions.
• Give intravenous injection at no more than 4 ml/ min, intermittent intravenous infusion at 5 to
7 ml/min, and continuous intravenous infusion at 6.25 mg/hr (except with hypersecretory conditions, when initial infusion rate is 1 mg/kg/hr, gradually increased after 4 hours, as needed, in increments of 0.5 mg/kg/hr).
• Don't add additives to premixed solution.
• Stop primary intravenous solution infusion during piggyback administration.
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Ranitidine
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Ranitidine Injection; Ranitidine Oral Solution; Ranitidine Tablets;
The United States Pharmacopeia 31, 2008: Ranitidine in Sodium Chloride Injection; Ranitidine Injection; Ranitidine Oral Solution; Ranitidine Tablets.
Proprietary Preparations
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