Zocor (Simvastatin)
Class and Category of Drug
Before you buy Zocor (Simvastatin) online, read common information about the medication.
Chemical class: Synthetically derived fer-
mentation product of Asp ergillus terreus
Therapeutic class: Antihyperlipidemic
Pregnancy category: X
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Drug Indications and Dosages
Before purchase Zocor (Simvastatin) online , you must read how it works.
To treat hyperlipidemia
Tablets
Adults. Initial: 20 to 40 mg daily in the evening. Dosage adjusted at 4-wk intervals, as needed, to achieve target LDL-cholesterol level. Maintenance: 5 to 80 mg daily. Maximum: 80 mg daily.
To treat homozygous familial hypercholesterolemia
Tablets
Adults. 40 mg daily in the evening, or 80 mg/day in 3 divided doses — 20 mg, 20 mg, and 40 mg (in the evening). Dosage adjusted every 4 wk, as needed, to achieve target LDL-cholesterol level. Maintenance: 5 to 40 mg/day. Maximum: 80 mg daily.
Dosage Adjustment Patients taking cyclosporine or who have severe renal insufficiency should initially receive 5 mg simvastatin daily and be increased as needed to no more than 10 mg daily. Maximum dosage of 10 mg daily should also not be exceeded in patients who are also taking fibrates or niacin.
To treat adolescent heterozygous familial hypercholesterolemia
Tablets
Children ages 10 to 17 at least 1 year post-menarche. Initial: 10 mg daily in the evening. Adjusted every 4 wk, as needed, to achieve target LDL-cholesterol level. Maintenance: 10 to 40 mg daily. Maximum: 40 mg daily.
Dosage Adjustment For patients who take cyclosporine, initial dosage reduced to 5 mg/day and maximum dosage reduced to 10 mg/day. For elderly patients and those with renal impairment, initial dosage reduced to 5 mg daily. For patients who take danazol, fibric-acid derivative lipid-lowering drugs, such as gemfibrozil, or lipid-lowering doses of niacin (1 g daily or more), maximum dosage reduced to 10 mg daily. For patients who take amiodarone or verapamil, maximum dosage shouldn't exceed 20 mg daily.
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Contraindications of Drug
Read contraindications if you want cheap Zocor (Simvastatin) online.
Active hepatic disease; breast-feeding; concurrent use with clarithromycin, erythromycin, more than 1 quart of grapefruit juice daily, HIV protease inhibitors, itraconazole, ketoconazole, nefazodone, or telithromycin; hypersensitivity to simvas-tatin or its components; pregnancy
Generic Drug Interactions
Drugs
amiodarone, antiretroviral protease inhibitors (amprenavir, indinavir, nelfinavir, ritonavir, saquinavir), clarithromycin, cyclosporine, danazol, gemfibrozil and other fibrates, itraconazole, ketoconazole, erythromycin, nefazodone, niacin (1 g daily or more), telithromycin, verapamil: Increased risk of myopathy or rhabdomyolysis
azole antifungals, cyclosporine, gemfibrozil,
immunosuppressants, macrolide antibiotics (including erythromycin), niacin, verapamil: Increased risk of acute renal failure
bile acid sequestrants, cholestyramine, colestipol: Decreased simvastatin bioavailability
digoxin: Possibly slight elevation in blood digoxin level
diltiazem, verapamil: Possibly increased blood simvastatin level, increased risk of myopathy
oral anticoagulants: Increased bleeding or prolonged PT
Foods
grapefruit juice (1 or more quarts daily):
Possibly increased blood simvastatin level
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Drugs Adverse Reactions
Central Nervous System: Asthenia, dizziness, fatigue, headache
Cardiovascular: Chest pain
Eyes, Ears, Nose, And Throat: Cataracts, rhinitis
Gastrointestinal: Abdominal pain, constipation, diarrhea, elevated liver function test results, flatulence, heartburn, hepatic failure, indigestion, nausea, pancreatitis, vomiting
Musculoskeletal: Myalgia, myopathy, rhabdomyolysis
Respiratory: Upper respiratory tract infection
Skin: Eczema, pruritus, rash
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Nursing Considerations for Generic Drugs
• Use simvastatin cautiously in elderly patients and those with renal or hepatic impairment.
• Give drug 1 hour before or 4 hours after giving bile acid sequestrant, cholestyramine, or colestipol.
• Expect to monitor liver function test results every 3 to 6 months for abnormal elevations.
• Monitor serum lipoprotein level, as ordered, to evaluate response to therapy.
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Simvastatin
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Simvastatin Tablets;
The United States Pharmacopeia 31, 2008: Simvastatin Tablets.
Proprietary Preparations
Argentina: Coledis; Colesterminol; Dosavastatin; Gemistatin; Klonastin; Labistatin; Lipimibe; Lisac; Nivelipol; Nosterol; Redusterol; Sevacol; Several; Tanavat; Vasotenal; Zocor;
Australia: Lipex; Ransim; Simvabell; Simvahexal; Simvar; Zimstat; Zocor;
Austria: Gerosim; Nyzoc; SimcorHexal; Simstin; Simvarcana; Simvastad; Simvatin; Zocord;
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Belgium: Cholemed; Docsimvasta; Simvafour; Simvastamed; Zocor;
Brazil: Androlip; Clinfar; Cordiron; Lipotex; Liptrat; Lovacor; Menocol; Mivalen; Revastin; Sinvalip; Sinvascor; Sinvastacor; Sinvastamed; Sinvastin; Sinvatrox; Sinvax; Sinvaz; Sivastin; Vaslip; Vastatil; Zocor;
Canada: Zocor;
The pharmaceutical companies our pharmacies buy from follow strict WHO standards for GMP.
Chile: Arterosan; Nimicor; Simvass; Vasomed; Vasotenal; Zocor;
Czech Republic: Apo-Simva; Corsim; Egilipid; Sim; Simbela; Simgal; Simirex; Simva; Simvacard; Simvax; Simvor; Vasilip; Zocor;
Denmark: Perichol; Zocolip; Zocor;
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Finland: Corolin; Lipcut; Zocor;
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France: Lodales; Zocor;
Germany: BeL; Denan; Simva; SimvaAPS; Simvabeta; Simvacard; Simvacor; Simvadoc; Simvadura; Simvagamma; Simvalip; Zemox; Zocor;
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Greece: Antichol; Arstatin; Avatratin; Bevostatin; Christatin; Doctiverine; Extrastatin; Glipal; Goldastatin; Iamastatin; Ipramid; Kymazol; Lepur; Lip-Down; Lipomin; Lipopress; Liporex; Lipozid; Lowcholid; Lusimva; Medistatin; Nitastin; Normotherin; Placol; Prelon; Priacin; Prizelip; Raptor; Ravostan; Redusterol; Simplaqor; Simvachol; Simvacor; Simvalark; Simvalid; Simvaprol; Simvatin; Sivinar; Sotovastin; Starezin; Stasiva; Statinal; Statinum; Stativer; Statosan; Stazor; Sterylip; Vassor; Vastatin; Velkastatin; Zocor; Zurocid;
Hong Kong: Avastinee; Corstat; Covastin; Qualicor; Simcard; Simtin; Vasilip; Vidastat; Zocor;
Hungary: Awestatin; Sicor; Simvacol; Simvagamma; Simvep; Simvor; Vasilip; Zocor;
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India: Biosim; Simcard; Simchol; Simlo; Simvotin;
Indonesia: Cholestat; Detrovel; Esvat; Ethicol; Lipinorm; Mersivas; Normofat; Pontizoc; Rechol; Rendapid; Simbado; Simchol; Simcor; Sinova; Valemia; Vazim; Vidastat; Zocor; Zovast;
Ireland: Ritechol; Simator; Simtan; Simzor; Sivatin; Zocor; Israel: Simovil; Simvacor; Simvaxon;
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Italy: Liponorm; Medipo; Sinvacor; Sivastin; Zocor;
Malaysia: Covastin; Simcard; Simtin; Simvacor; Simvor; Stavid; Vascor; Zocor;
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Mexico: Apomastina; Colesken; Fansia; Imbistad; Josken; Pulsar-AT Dual; Simplaqor; Tulip; Zeid; Zocor; Zorced;
Netherlands or Holland: Altercor; Simva; Zocor;
Norway: Zocor;
New Zealand: Lipex; Sim- Statin;
Philippines: Cholestad; Eurocor; Euvasten; Forcad; Ivast; Lipivas; Normastin; Orovas; Simtin; Simvahex; Uni-Per; Vastilan; Vidastat; Wilsim; Zivas; Zocor; Zolvastin; Zovast;
Poland: Cardin; Simgal; Simratio; Simredin; Simvacard; Simvachol; Simvacor; Simvahexal; Simvasterol; Vasilip; Vastan; Ximve; Zocor;
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Portugal: Colvastina; Dislipina; Jabastatina; Lipaz; Simvacol; Simvasim; Sinpor; Sintar; Sinvastil; Sumaclina; Tavitan; Vascorim; Zera; Zocor;
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