Zofran (Ondansetron)
Class and Category of Drug
Before you buy Zofran (Ondansetron) online, read common information about the medication.
Chemical class: Carbazole
Therapeutic class: Antiemetic
Pregnancy category: B
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Drug Indications and Dosages
Before purchase Zofran (Ondansetron) online , you must read how it works.
To prevent chemotherapy-induced nausea and vomiting
Disintegrating Tablets, Oral Solution,Tablets
Adults and children age 12 and over. Initial: 8 mg given 30 min before chemotherapy. After chemotherapy: 8 mg given 8 hr after initial dose; then 8 mg every 12 hr for 1 to 2 days.
Children ages 4 to 12. Initial: 4 mg given 30 min before chemotherapy. After chemotherapy: 4 mg given 4 and 8 hr after initial dose; then 4 mg every 8 hr for 1 to 2 days.
Intravenous Infusion
Adults. 32 mg infused over 15 min starting 30 min before chemotherapy; or three 0.15-mg/kg doses, each infused over 15 min, starting with first dose given 30 min before chemotherapy and second and third doses given 4 and 8 hours after first dose. Children ages 6 months to 18 years. Three 0.15-mg/kg doses, each infused over 15 min, starting with first dose given 30 min before chemotherapy and second and third doses given 4 and 8 hours after first dose.
To prevent postoperative nausea and vomiting
Disintegrating Tablets, Oral Solution,Tablets
Adults. 16 mg as a single dose 1 hr before anesthesia induction.
Intravenous Injection
Adults and children age 12 and over. 4 mg as a single dose over 2 to 5 min just before anesthesia induction or if nausea or vomiting develops shortly after surgery. Children ages 2 to 12 weighing more than 40 kg (88 lb). 4 mg as a single dose over 2 to 5 min just before anesthesia induction or if nausea or vomiting develops shortly after surgery.
Children ages 1 month to 12 years weighing less than 40 kg. 0.1 mg/kg as a single dose over 2 to 5 min just before or immediately after anesthesia induction or if nausea or vomiting develops shortly after surgery.
Intramuscular Injection
Adults and children age 12 and over. 4 mg as a single dose just before anesthesia induction or if nausea or vomiting develops shortly after surgery.
To prevent nausea and vomiting after radiation therapy
Disintegrating Tablets, Oral Solution,Tablets
Adults and children age 12 and over. Initial: 8 mg as a single dose given 1 to 2 hr before radiation therapy. Posttherapy: 8 mg every 8 hr, as needed and tolerated.
Dosage Adjustment For patients with hepatic impairment, maximum dosage limited to 8 mg daily intravenous or P.O.
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Contraindications of Drug
Read contraindications if you want cheap Zofran (Ondansetron) online.
Hypersensitivity to ondansetron or its components
Generic Drug Interactions
Drugs
cisplatin, cyclophosphamide: Possibly altered blood levels of these drugs
Activities
alcohol use: Increased stimulant and sedative effects, including mood and physical sensations
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Drugs Adverse Reactions
Central Nervous System: Agitation, akathisia, anxiety, ataxia, dizziness, drowsiness, fever, headache, hypotension, restlessness, seizures, syncope, somnolence, weakness
Cardiovascular: Arrythmias, chest pain, hypotension, pulmonary embolism, shock, tachycardia, transient prolonged QT interval
Eyes, Ears, Nose, And Throat: Accommodation disturbances, altered taste, blurred vision, dry mouth, laryngeal edema, laryngospasm, transient blindness
Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, elevated liver function test results, flatulence, indigestion, intestinal obstruction, thirst
Respiratory: Bronchospasm, shortness of breath
Skin: Flushing, hyperpigmentation, maculopapular rash, pruritus
Other: Anaphylaxis, angioedema, injection site burning, pain, and redness
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Nursing Considerations for Generic Drugs
WARNING Be aware that oral disintegrating tablets may contain aspartame, which is metabolized to phenylalanine and must be used cautiously in patients with phenylketonuria.
• Place disintegrating tablet on patient's tongue immediately after opening package. It dissolves in seconds.
• Use calibrated container or oral syringe to measure dose of oral solution.
• Give up to 4 mg intravenous diluted in 50 ml of D5W or normal saline solution.
WARNING Be aware that ondansetron may mask symptoms of adynamic ileus or gastric distention after abdominal surgery.
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