Zoloft (Sertraline)
Class and Category of Drug
Before you buy Zoloft (Sertraline) online, read common information about the medication.
Chemical class: Naphthylamine derivative
Therapeutic class: Antidepressant, anti-obsessant, antipanic
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Zoloft (Sertraline) online , you must read how it works.
To treat major depression
Oral Concentrate, Tablets
Adults. Initial: 50 mg daily, increased after several wk in increments of 50 mg daily every wk, as needed. Maximum: 200 mg daily.
To treat obsessive-compulsive disorder
Oral Concentrate, Tablets
Adults and adolescents. Initial: 50 mg daily, increased after several wk in increments of 50 mg daily every wk, as needed. Maximum: 200 mg daily. Children ages 6 to 12.Initial: 25 mg daily, increased every wk, as needed. Maximum: 200 mg daily.
To treat panic disorder, with or without agoraphobia; to treat posttraumatic stress disorder
Oral Concentrate, Tablets
Adults. Initial: 25 mg daily, increased to 50 mg daily after 1 wk; then increased by 50 mg daily every wk, as needed. Maximum: 200 mg daily.
Dosage Adjustment Initial dosage reduction recommended for elderly patients and those with hepatic impairment.
To treat premenstrual dysphoric disorder (PMDD)
Oral Concentrate, Tablets
Adult women. Initial: 50 mg daily in morning or evening throughout menstrual cycle; or, 50 mg daily in morning or evening during luteal phase of menstrual cycle only. Dosage increased each menstrual cycle in 50-mg increments up to 150 mg daily, or each luteal phase up to 100 mg daily, as needed. Once 100-mg daily dosage established for luteal phase, each successive cycle requires a 50-mg titration step for 3 days at the beginning of each luteal phase. Maximum: 150 mg daily for dosing throughout menstrual cycle, or 100 mg daily for dosing during luteal phase only.
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Contraindications of Drug
Read contraindications if you want cheap Zoloft (Sertraline) online.
Concurrent use of disulfiram (oral concentrate) or pimozide; hypersensitivity to sertraline or its components; use within 14 days of an MAO inhibitor
Generic Drug Interactions
Drugs
aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin: Increased anticoagulant activity and risk of bleeding astemizole, terfenadine: Possibly increased blood levels of these drugs, leading to increased risk of arrhythmias cimetidine: Increased sertraline half-life MAO inhibitors: Possibly hyperpyretic episodes, hypertensive crisis, serotonin syndrome, and severe seizures moclobemide, serotonergics: Increased risk of potentially fatal serotonin syndrome serotonin and norepinephrine reuptake inhibitors: Increased risk of bleeding, especially gastrointestinal bleeding
tolbutamide: Possibly hypoglycemia tricyclic antidepressants: Possibly impaired metabolism of tricyclic antidepressants, resulting in increased risk of toxicity
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Drugs Adverse Reactions
Central Nervous System: Aggressiveness, agitation, anxiety, dizziness, drowsiness, fatigue, fever, headache, hyperkinesia, insomnia, nervousness, neuroleptic malignant syndrome-like reaction, paresthesia, serotonin syndrome, suicidal ideation, tremor, weakness, yawning
Cardiovascular: Palpitations
Eyes, Ears, Nose, And Throat: Dry mouth, epistaxis, sinusitis, vision changes
Endocrine: Syndrome of inappropriate ADH secretion
Gastrointestinal: Abdominal cramps, anorexia, constipation, diarrhea, flatulence, increased appetite, indigestion, nausea, vomiting
Genitourinary: Anorgasmia, decreased libido, ejaculation disorders, impotence, urinary incontinence
Skin: Diaphoresis, flushing, purpura, rash
Other: Weight loss
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Nursing Considerations for Generic Drugs
•Monitor liver function test results and BUN and serum creatinine levels, as mix it with 4 oz (one-half cup) of water, ginger ale, lemon or lime soda, lemonade, or orange juice. Warn him not to mix oral concentrate with anything else. Explain that it's normal for mixture to be slightly hazy.
• Tell patient to take dose immediately after mixing it.
• If patient has latex sensitivity, advise him to use an alternate dispenser because the supplied dropper dispenser contains dry natural rubber.
• Advise patient to avoid hazardous activities until drug's CNS effects are known.
• Warn family or caregiver to watch patient closely for evidence of suicidal thinking or behavior, especially when therapy starts or dosage changes, and especially if patient is a child or adolescent.
• Caution patient not to stop taking drug abruptly. Explain that gradual tapering helps to avoid withdrawal symptoms.
• Instruct female patients to notify prescriber if they are or could be pregnant and to discuss benefits and risks of continuing sertraline therapy throughout the pregnancy.
• Advise patient to consult prescriber before taking any OTC product, especially aspirin products or NSAIDs.
WARNING Monitor patient closely for evidence of serotonin syndrome, such as agitation, hallucinations, coma, tachycardia, labile blood pressure, hyperthermia, hyperreflexia, incoordination, nausea, vomiting, and diarrhea. Serotonin syndrome in its most severe form can resemble neuroleptic malignant syndrome, which includes hyperthermia, muscle rigidity, autonomic instability, possibly rapid changes in vital signs, and mental status changes. Notify prescriber immediately because serotonin syndrome reactions that resemble neuroleptic malignant syndrome may be life-threatening. Be prepared to provide supportive care.
• Monitor patient for hypo-osmolarity of serum and urine and for hyponatremia, which may indicate sertraline-induced syndrome of inappropriate ADH secretion.
• Be aware that effective antidepressant therapy can promote development of mania in predisposed people. If mania develops, notify prescriber immediately and expect to withhold sertraline.
• Watch closely for suicidal tendencies, espe daily when therapy starts and dosage changes and especially in children and adolescents.
• Monitor patient closely for evidence of gastrointestinal bleeding, especially if patient takes a drug known to cause it, such as aspirin, an NSAID, a serotonin or norepinephrine reuptake inhibitor, or warfarin.
• When theray stops, expect to taper dosage to minimize adverse effects rather than stopping drug abruptly.
Sertraline
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
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