Zovirax (Acyclovir)

Zovirax (Acyclovir)

Class of drug: Antiviral agent.

Before you buy Zovirax (Acyclovir) online, read common information about the medication.

Mechanism of action of drug: Nucleotide analog; inhibits viral replication by termination of viral DNA chain and inhibition and inactivation of viral DNA polymerase.

Indications / Dosage / Route: Oral, IV.
• Herpes simplex (HSV-1 and HSV-2) infections (immunocom-promised host)
Adults, children >12 years: IV 5 mg/kg (infuse at constant rate over 1 hour), q8h for 7 days.
Children <12 years: IV250 mg/m2 (infuse at constant rate for 1 hour), q8h.
• Genital herpes
Adults, children >12 years: PO 200 mg q4h, five doses/day; 10 days for initial therapy. Dose for 5 days for intermittent recurrent disease. Administer up to 12 months for chronic disease (suppressive therapy).
Children <12 years: IV 250 mg/m2, t.i.d. for 10 days.
• Herpes simplex encephalitis
Adults, children >12 years: IV 10 mg/kg (infuse at constant rate over 1 hour), q8h for 10 days.
Children, 6 months to 12 years: IV 500 mg/m2 (infuse at constant rate over 1 hour), q8h for 10 days.
• Herpes zoster
Adults, children >12 years: PO 80 mg, q4h, five doses/day, 7-10 days.
Children <12 years: PO 250-600 mg/m2, 4-5 times/day, 7-10 days.
• Chickenpox
Adults, children >40 kg: PO 800 mg, q.i.d. 5 days.
Children >2 years: PO 20 mg/kg q.i.d. (maximum 800 mg), 5 days.

Drug Dosage Adjustment

• Kidney disease: Creatinine clearance 25-50 mL/min: dose q12h; creatinine clearance 10-25 mL/min: dose q24h; creatinine clearance <10 mL/min: half dose q24h (IV doses).
• Liver disease: None.
• Elderly: None.
• Pediatric: Safety has not been established in children <2 years old.

Food: No restrictions.

Pregnancy: Category C.

Lactation: Appears in breast milk; considered compatible by American Academy of Pediatrics.

Contraindications: Hypersensitivity to acyclovir.

Before purchase Zovirax (Acyclovir) online , you must read how it works.

Warnings/precautions

• Use with caution in patients with the following conditions: kidney disease, neurologic disease.
• Beware of renal dysfunction especially if patient is taking other nephrotoxic drugs.
• Women with genital herpes should have annual Pap smears.
• Rapid bolus administration may cause crystalline precipitation in renal tubules and renal insufficiency.
• Patients receiving acyclovir IV must remain well hydrated during treatment and for 24 hours after treatment.
• Cases of thrombotic thrombocytopenic purpura/hemolytic uremia syndrome have been reported with high-dose acyclovir in immunocompromised patients.

Advice to patient

• Drink 2-3 L of fluid per day. This is particularly important following IV infusion.
• Avoid sexual intercourse when lesions are present; otherwise use condoms.
• Avoid contact of the drug with or around the eyes.
• Resume treatment at first indication of recurrence of infection.

Adverse Drug Reactions

• Common: headache, phlebitis (IV only).
• Serious: seizures, renal failure, anaphylaxis, encephalopathy (confusion, hallucinations), coma, leukopenia, renal crystalline precipitant, elevated liver enzymes, Stevens-Johnson syndrome, urticaria.

Clinically important drug interactions

• Drugs that increase effects/toxicity of acyclovir: MAO inhibitors, probenecid, ziduvine, CNS depressants.
• Drugs that decrease effects/toxicity of acyclovir: beta blockers, guanethidine.

Parameters to monitor

• Serum BUN and creatinine, CBC with differential and platelets, liver enzymes.
• Signs and symptoms of ocular herpetic infection as this may cause blindness.
• Serum creatinine level: If this increases during therapy, adjust dose, increase hydration or discontinue drug.
• Signs and symptoms of hepatotoxicity.
• Signs and symptoms of renal toxicity.
• Signs and symptoms of drug-induced psychologic disturbances: Changes in mood, behavior or orientation of patient, agitation, hallucinations, suicidal tendencies, sleep disturbances, lethargy.
• Intake of fluids and urinary and other fluids. Closely monitor electrolyte levels.
Remember it if you buying Zovirax (Acyclovir) online.

Aciclovir

Preparations

International Brand Drug Names

The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.

British Pharmacopoeia, 2008 edition: Aciclovir Cream; Aciclovir Eye Ointment; Aciclovir Intravenous Infusion; Aciclovir Oral Suspension; Aciclovir Tablets; Dispersible Aciclovir Tablets;
The United States Pharmacopeia 31, 2008: Acyclovir Capsules; Acyclovir for Injection; Acyclovir Ointment; Acyclovir Oral Suspension; Acyclovir Tablets.

Proprietary Preparations

Argentina: Acerpes; Aciclo; Aciclotex; Apofarm; Dioxis; Lafevir; Lisovyr; Poviral; Virostatic; Xiclovir; Zovirax;
Australia: Acihexal; Acyclo-V; Chemists Own Cold Sore; Lovir; Ozvir; Zolaten; Zovirax; Zyclir;
Austria: Acic; Aciclobene; Aciclostad; Aciclotyrol; Activir; Acyclox; Exviral; Farocid; Fibral; Herpomed; Nycovir; Simplex-Fieberblasen; Stadovir; ViroMed; Xorox; Zovirax;
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Belgium: Aciclomed; Aciclophar; Docaciclo; Viratop; Zovirax;
Brazil: Aciclomed; Aciclor; Aciclovan; Aciveral; Acivirax; Anclomax; Antivirax; Aviral; Ciclavix; Ciclocris; Clovir; Ductovirax; Exavir; Ezopen; Heclivir; Herpesil; Hervirax; Hpvir; Uni Vir; Ziclovir; Zovirax; Zoylex;
Canada: Avirax; Zovirax;
The pharmaceutical companies our pharmacies buy from follow strict WHO standards for GMP.
Chile: Eurovir; Lisovyr; Oftavir; Vironida; Zovirax;
Czech Republic: Acyclostad; Herpesin; Herpotern; Provirsan; Ranvir; Supraviran; Viro; Virolex; Xorox; Zovirax;
Denmark: Aciclodan; Acivir; Avirox; Geavir; Herpavir; Orivir; Zovir;
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Finland: Aclovir; Acyclostad; Acyrax; Antix; Geavir; Herpolips; Zovirax;
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France: Aciclovivax; Activir; Kendix; Virucalm; Zovirax;
Germany: Acerpes; Acic; Acic-Ophtal; Aciclo; Aciclobeta; Aciclostad; Acivir; Dynexan Herpescreme; Herpetad; Juviral; Mapox; Supraviran; Virax; Virupos; Viruseen; Virzin; Zoliparin; Zovirax;
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Hungary: Acyclostad; Herpesin; Telviran; Virokill; Virolex; Zovirax;
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India: Acivir; Cyclovir; Herpex; Ocurax; Zovirax;
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Japan: Zovirax;
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Netherlands or Holland: Herpolips; Kruidvat Koortslipcreme; Zovirax;
Norway: Zovirax;
New Zealand: Acicvir; Lovir; Viraban; Zolaten; Zovirax;
Philippines: Acyhex; Cyclostad; Herpex; Klozivex; Virest; Zovirax;
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Russia: Aciclostad (Ациклостад); Cyclovir (Цикловир); Herpesin (Герпесин); Lovir (Ловир); Medovir (Медовир); Virolex (Виролекс); Vivorax (Виворакс); Zovirax (Зовиракс);
South Africa:
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France: Acitab DT; Acitop; Activir; Cyclivex; Lovire; Vyrohexal; Zovirax;
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Spain: Aciclostad; Bel Labial; Maynar; Milavir; Virherpes; Virmen; Viruderm; Zovirax;
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Sweden: Anti; Geavir; Zovirax;
Switzerland: Acerpes; Acivir; Aviral; Helvevir; Virucalm; Zovirax;
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Turkey: Acyl; Aklovir; Asiviral; Hernovir; Herpeks; Klovireks-L; Provir; Silovir; Virosil; Virupos; Xorox; Zovirax; UAE: Lovrak;
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